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Isis Reports Financial Results and Highlights for Fiscal year 2007
Date:3/13/2008

in 2006. Revenue was higher in the fourth quarter of 2007 compared to the same period of 2006 due to the addition of new revenue generating collaborations with Bristol-Myers Squibb (BMS) in May 2007 and Ortho-McNeil, Inc. (OMI) in September 2007. In addition to the revenue from these two strategic partnerships, the $26.5 million in sublicensing revenue that Isis earned in the third quarter of 2007 from Alnylam contributed to the significant year over year increase in revenue. Quarter-to-quarter fluctuations in revenue are common for Isis as its revenue is significantly affected by the nature and timing of payments under agreements with its partners, including license fees and milestone-related payments, such as the $26.5 million Isis received from Alnylam in the third quarter.

Expenses

In 2007, as its drugs advanced into and through development, Isis expanded its clinical development programs, resulting in an increase in operating expenses of $5.0 million in 2007 compared to 2006. Additionally, Isis built the manufacturing, marketing and sales infrastructure required to successfully commercialize the Ibis T5000(TM) Biosensor System, resulting in an increase in operating expenses of $4.9 million in 2007 compared to 2006. On a pro forma basis, operating expenses for the quarter and year ended December 31, 2007 were $30.5 million and $98.7 million, respectively, compared to $27.2 million and $87.4 million for the same periods in 2006.

Isis' operating expenses for the quarter and year ended December 31, 2007 were $33.2 million and $108.6 million, respectively, compared to $28.7 million and $92.7 million for the same periods in 2006, according to GAAP. Isis includes in its operating results non-cash compensation expense related to stock options, which was $2.7 million and $9.9 million for the quarter and year ended December 31, 2007, respectively, compared to $1.6 million and $5.7 million for the same periods in 2006, primarily reflecting the signifi
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SOURCE Isis Pharmaceuticals, Inc.
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