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Isis Reports Financial Results and Highlights for Fiscal year 2007
Date:3/13/2008

ditional Ibis T5000 Biosensor Systems.

* Ibis will focus on completing the next steps in its Abbott

transaction.

Regulus

2008 will mark a year of substantial growth for Regulus as the company initiates focused drug discovery programs that will take advantage of the therapeutic opportunities that microRNAs offer. In 2007 and early 2008, Regulus recruited a strong senior management team to drive this growth.

* Regulus will initiate additional drug discovery programs.

Corporate Development

Isis plans to continue the momentum and successes of 2007 and early 2008 throughout the rest of the year. This includes the continued growth of the Company's core antisense technology, the addition of new and novel drugs into development as well as maintaining and adding to a broad range of partnerships.
* Isis will support its current partnerships to ensure success.

* Isis will continue to advance its pipeline and to build its revenue

stream by adding new partnerships and/or satellite company

relationships.

Conference Call

At 08:30 a.m. Eastern Time today, March 13, Isis will conduct a live webcast conference call to discuss this earnings release and related activities. Interested parties may access the webcast at http://www.isispharm.com, or listen to the call by dialing 877-718-5107. A webcast replay will be available for a limited time at the same address.

About Isis Pharmaceuticals, Inc.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. I
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SOURCE Isis Pharmaceuticals, Inc.
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