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Isis Reports Financial Results and Highlights for Fiscal year 2007
Date:3/13/2008

position significantly in 2007, strengthening its balance sheet and reducing its net operating loss.
* Isis refinanced its convertible debt, which extended the maturity of

the debt, strengthened the Company's balance sheet, and reduced its

cash interest payments by approximately $2.6 million annually due to

the lower coupon rate.

* Isis purchased Symphony GenIsis relatively early in the term of that

financing arrangement saving approximately $75 million in the

predetermined purchase price, regaining full ownership of mipomersen,

which Isis licensed to Genzyme, and the GCGR and GCCR drugs, which

Isis licensed to OMI.

* As a result of Isis' partnering strategy, the Company was able to

reduce its pro forma net operating loss guidance by $40 million over

the course of 2007.

Isis strengthened its leadership team with the addition of:

* Jeffrey M. Jonas, M.D. to lead Clinical Development, Preclinical

Development, Regulatory Affairs, and Quality Assurance and Compliance.

Dr. Jonas was formerly Chief Medical Officer and Executive Vice

President at Forest Laboratories, Inc.

Regulus Highlights

Isis and Alnylam founded Regulus Therapeutics LLC and hired senior management to lead the joint venture company in discovering and developing antisense drugs targeting microRNAs.
* Kleanthis G. Xanthopoulos, Ph.D., was appointed as President and Chief

Executive Officer of Regulus. Dr. Xanthopoulos is the co-founder and

former President and Chief Executive Officer of Anadys

Pharmaceuticals, Inc.

* Peter S. Linsley, Ph.D., was appointed as Chief Scientific Officer of

Regulus. Dr. Linsley was Executive Director of Cancer Biology at

Merck Research Laboratories, and was previously Vice President of

Research of Rosetta Inpharmatics.


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SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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