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Isis Reports Financial Results and Highlights for Fiscal year 2007

million upfront licensing fee and

could receive more than $230 million in milestone payments, and Isis

established a research collaboration with OMI to identify additional

antisense drugs to treat metabolic diseases. Isis received the first

development milestone payment of $5 million under this collaboration.

* Isis licensed its lipid-lowering PCSK9 program to BMS for a

$15 million upfront licensing fee and up to $168 million in milestone

payments. Isis expanded clinical opportunities for its drugs by licensing several antisense drugs that are outside of the Company's key therapeutic focus areas to companies with disease-area expertise devoted to optimizing the future development of these drugs.
* Isis licensed ISIS 369645, an inhaled antisense drug, to Altair for

the treatment of respiratory diseases.

* Isis entered into a collaboration with Excaliard to discover and

develop antisense drugs for the local treatment of fibrotic diseases,

including scarring.

* Isis licensed alicaforsen, an antisense drug targeting ICAM-1 for

ulcerative colitis, to Atlantic Healthcare. Isis demonstrated the value of its technology innovation and dominant intellectual property through partnerships with industry leaders in a variety of related areas.
* Isis received $26.5 million under its collaboration with Alnylam,

associated with Alnylam's transaction with Roche.

* Isis licensed technology to Archemix for aptamer drug applications in

exchange for milestones and royalties on aptamer drugs developed by

Archemix that incorporate Isis' proprietary chemistries or

manufacturing methods; Isis received the first milestone payment from

Archemix for the advancement of Archemix' aptamer drug into Phase 2a


Other Highlights

Isis has improved its financial

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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