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Isis Reports Financial Results and Highlights for Fiscal year 2007
Date:3/13/2008

for ISIS 333611, an antisense drug

in IND-enabling studies that targets SOD1 for the treatment of an

inherited, aggressive form of ALS, which is also known as Lou Gehrig's

disease. IND-enabling preclinical studies are being funded by the ALS

Association and the Muscular Dystrophy Association.

* Isis initiated a program to discover and develop antisense drugs to

treat Huntington's Disease in collaboration with CHDI, which is

providing Isis with nearly $10 million in funding for the program.

* Antisense Therapeutics Ltd. (ATL) licensed ATL1102 to Teva

Pharmaceutical Industries. ATL1102 is an antisense drug discovered by

Isis and licensed to ATL and is currently in Phase 2 studies for the

treatment of multiple sclerosis.

* iCo initiated Phase 1 studies of iCo-007, an antisense drug discovered

by Isis for the treatment of various eye diseases. Isis received a

$1.25 million milestone payment in equity for the initiation of this

study.

Partnership Highlights

Isis has added three major new pharmaceutical partners for drugs in its cardiovascular and metabolic franchises, underscoring the confidence of the industry in the promise of antisense drugs for treatment of chronic conditions such as these:
* Isis licensed mipomersen to Genzyme as part of a strategic alliance

that includes a $150 million equity investment, an upfront licensing

fee of $175 million, over $1.5 billion in milestone payments, and a

share of profits on mipomersen and follow-on drug(s) ranging from

30-50% of all commercial sales. As part of the alliance, Genzyme

became a preferred development partner for Isis for programs in CNS

and certain rare diseases.

* Isis licensed two type 2 diabetes drugs that target GCGR and GCCR to

Johnson & Johnson's OMI for a $45
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SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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