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Isis Reports Financial Results and Highlights for Fiscal year 2007

glucose without causing low blood sugar, called hypoglycemia,

weight gain or nausea.

* Isis initiated Phase 1 studies of ISIS 325568, an antisense drug

partnered with OMI, that targets the glucagon receptor, GCGR.

* Isis identified a development candidate, ISIS 377131, an antisense

drug also partnered with OMI that

targets the glucocorticoid receptor, GCCR.

* Isis added ISIS 388626 to its development pipeline. ISIS 388626

targets SGLT2, a protein that is responsible for glucose re-absorption

in the kidney. Cancer continues to be a disease in which antisense drugs could make a profound difference in treatment options. Isis' partners are developing antisense drugs discovered by Isis to treat cancer.
* OncoGenex reported encouraging Phase 2 data for OGX-011, an antisense

drug that targets clusterin, in several studies in patients with

advanced prostate or lung cancers. The most recent study showed that

OGX-011 was well-tolerated in combination with certain chemotherapy

agents and showed ongoing survival durations that were more favorable

than with the chemotherapy agents alone, based on historical controls.

* OncoGenex initiated Phase 1 clinical studies of OGX-427, an antisense

drug that targets Hsp27, a cell survival protein that is overly

abundant in cancer cells.

* Lilly advanced its Phase 1 studies of LY2275796, which targets eIF-4E,

a protein involved in tumor progression and in the Journal of Clinical

Investigation, Isis and Lilly published preclinical study results that

support the therapeutic potential of LY2275796. Isis is exploring new applications and disease indications for antisense drugs to treat neurodegenerative diseases and other diseases for which antisense drugs are uniquely suited.
* Isis was granted orphan drug status

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
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