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Isis Reports Financial Results and Highlights for Fiscal year 2007
Date:3/13/2008

successes, we have the opportunity to aggressively advance our drugs in development, with significant data milestones planned for our two most advanced drugs, mipomersen and ISIS 113715, and expand our pipeline with two to four new drugs. Our partnering successes over the last year have created substantial interest in Isis and our technology, which we plan to exploit with new strategic relationships. In short, we believe 2007 is just the beginning of value creation from Isis' antisense platform and look forward to an exciting upcoming year," concluded Ms. Parshall.

Drug Development Highlights

Isis' cardiovascular franchise matured appreciably during the last year, with mipomersen at the forefront. The clinical success of mipomersen has added significant value to the entire drug development pipeline.
* Mipomersen (formerly ISIS 301012) continues to demonstrate an

excellent safety and efficacy profile supported by strong Phase 2

clinical results in all patient populations tested. As a result, Isis

has initiated registration studies of mipomersen in Familial

Hypercholesterolemia patients.

* Isis established a strategic alliance with BMS for the discovery and

development of antisense drugs targeting PCSK9, an important regulator

of the LDL-receptor.

* Isis initiated IND-enabling studies of ISIS 353512, an antisense drug

that targets C-reactive protein, in partnership with the Korea

Institute of Technology. Isis' metabolic disease franchise continued to expand with the addition of new diabetes drugs into development, and new research efforts toward attractive targets for the treatment of obesity.
* Isis continued Phase 2 studies of ISIS 113715 for the treatment of

type 2 diabetes in patients on stable sulfonylurea treatment. In

humans and preclinical studies, ISIS 113715 demonstrated reductions in

blood
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SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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