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Isis Reports Financial Results and Highlights for Fiscal year 2007
Date:3/13/2008

ommercial success through the earn out provision. We look forward to the benefit Ibis will receive from an experienced partner in diagnostics focused on Ibis' commercial success," added Ms. Parshall.

"We continue to place carefully selected antisense drugs in the hands of dedicated and highly focused partners for the treatment of diseases that are outside our core therapeutic areas. Altair Therapeutics and Excaliard Pharmaceuticals are two of our most recent examples of this business strategy, which enables us to benefit in the form of licensing and milestone payments and equity ownership in these venture-financed companies while also expanding the therapeutic reach of our antisense technology," added Ms. Parshall. "In addition, we leverage our investments in our core technologies and maintain our leadership position by providing access to our extensive patent estate and expertise enabling partners to develop new therapeutic approaches. As part of this strategy we received $26.5 million from Alnylam, in association with its Roche deal and added a new technology partner, Archemix, for discovery and development of aptamer drugs. We are also using our technology to expand into new biological areas such as microRNA with the formation of our joint venture Regulus Therapeutics, which will benefit from our extensive expertise, chemistry and technology as the company exploits new biological mechanisms for disease treatments. The caliber of the management team, Scientific Advisory Board and Board of Directors we have put together for Regulus is a reflection of the high level of excitement about this new area of biology and Regulus' leadership position in the field. All of these achievements provide the financial strength and momentum that make it likely that 2008 will be another year of excellent progress."

"The continued exploitation of Isis' unique and effective business strategy should produce another strong year in 2008. Building on our 2007 and early 2008
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SOURCE Isis Pharmaceuticals, Inc.
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