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Isis Reports Financial Results and Highlights for First Quarter of 2008
Date:5/12/2008

bis was also awarded up to approximately $2.8 million in government

contracts and grants.

-- Regulus Therapeutics

o Regulus, Isis' joint venture formed in September 2007, is focused on

developing microRNA therapeutics, as a new approach to target the

pathways of human disease. Last month, Regulus entered into a

strategic alliance with GSK that could provide up

to nearly $600 million to Regulus to develop microRNA-targeted

therapeutics to treat inflammatory disease.

-- Regulus received a $20 million upfront payment, including a

$15 million option fee and payment for a $5 million note that

will convert into Regulus common stock under certain

circumstances.

-- The alliance provides GSK with an option to license drug

candidates directed at four different inflammatory disease

microRNA targets.

-- Regulus will receive up to $144.5 million in development,

regulatory and sales milestone payments for each

microRNA-targeted drug discovered and developed as part of the

collaboration.

-- Regulus will also receive tiered royalties up to double digits

on sales of drugs resulting from the alliance.

Conference Call

At 08:30 a.m. Eastern Time today, May 12, Isis will conduct a live webcast conference call to discuss this earnings release and related activities. Interested parties may access the webcast at http://www.isispharm.com, or listen to the call by dialing 877-548-7906. A webcast replay will be available for a limited time at the same address.

About Isis Pharmaceuticals, Inc.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The C
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SOURCE Isis Pharmaceuticals, Inc.
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