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Isis Reports Financial Results and Highlights for First Quarter of 2008
Date:5/12/2008

d innovation in RNA-based technologies."

-- Mipomersen

Mipomersen, the most advanced drug in Isis' cardiovascular pipeline,

will be evaluated in a broad Phase 3 program in patients with high

cholesterol at high risk for cardiovascular disease including an

ongoing Phase 3 study in patients with homozygous Familial

Hypercholesterolemia (FH).

o Isis reported updated safety data on mipomersen from an ongoing

open-label extension study in 20 patients with FH that showed that

mipomersen continues to be well tolerated and maintains activity in

longer-term treatment.

o Isis reported the results of two preclinical studies in which the

lowering of apoB-100 resulted in the dramatic reduction of

atherosclerotic plaques in murine models of atherosclerosis.

o In April, Isis received guidance from the FDA on approval

requirements for mipomersen.

o Isis licensed mipomersen to Genzyme as part of a strategic alliance

for which the contracts are being finalized and the transaction is

expected to be completed this quarter. The deal included:

-- A $175 million mipomersen licensing fee

-- A $150 million equity investment (at $30 per share)

-- Over $1.5 billion in milestone payments for mipomersen

-- A share of profits on mipomersen and follow-on drug(s) ranging

from 30 to 50 percent of all commercial sales.

-- A preferred partner relationship for the development and

commercialization of antisense drugs for CNS and certain rare

diseases.

-- Pipeline Highlights

o Isis expanded its cardiovascular disease franchise with the addition

of a development candidate that targets PCSK9.

-- Isis received a $2 million milestone payment with the se
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SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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