Isis Reports Financial Results and Highlights for First Quart...(correct could cause its results to diffe...),Health

Date:5/12/2008

correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Isis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Isis' programs are described in additional detail in Isis' annual report on Form 10-K for the year ended December 31, 2007, which is on file with the SEC. Copies of this and other documents are available from the Company.

In this press release, unless the context requires otherwise, "Isis," "Company," "we," "our," and "us" refers to Isis Pharmaceuticals and its subsidiaries.

Isis Pharmaceuticals is a registered trademark of Isis Pharmaceuticals, Inc. Ibis Biosciences and Ibis T5000 are trademarks of Ibis Biosciences, Inc. Regulus Therapeutics is a trademark of Regulus Therapeutics LLC.

ISIS PHARMACEUTICALS, INC.

SELECTED FINANCIAL INFORMATION

Condensed Consolidated Statements of Operations

(In Thousands, Except Per Share Data)

Three months ended,

March 31,

2008 2007

(unaudited)

Revenue:

Research and development revenue under

collaborative agreements $20,686 $2,002

Licensing and royalty revenue 668 448

Total revenue 21,354 2,450

Expenses:

Research and development 26,449 19,949

Selling, general and administrative
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SOURCE Isis Pharmaceuticals, Inc. Copyright©2008 PR Newswire. All rights reserved

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