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Isis Receives Notice of Allowance That Expands the Scope of Key RNA Therapeutic Patents for Single-Stranded RNAi Technology
Date:9/10/2009

CAMBRIDGE, Mass. and CARLSBAD, Calif., Sept. 10 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) and Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY) announced today that the United States Patent and Trademark Office (USPTO) has allowed an Isis patent application that further expands the scope of the "Crooke" patent estate. The newly allowed patent broadly covers methods of cleaving a target RNA via a double-stranded ribonuclease mechanism, including the RNAi mechanism, with chemically modified, single-stranded RNA-containing drugs. Last year, Isis was awarded patents covering the compositions and methods of treating patients with a double-stranded or a single-stranded RNA-containing compounds, including double-stranded small interfering RNA (siRNA), which further strengthened Isis' broadly applicable intellectual property estate covering RNA-based drug discovery and development.

Isis' Crooke patent estate is a family of patents stemming from the innovative research of Stanley Crooke, M.D., Ph.D., and others at Isis to identify and design RNA molecules that utilize numerous different antisense mechanisms. Isis continues this research effort by utilizing its RNA expertise with its broad oligonucleotide medicinal chemistry endeavors to design drugs that are optimal to exploit each different mechanism and have attractive pharmaceutical properties. The Crooke patents are part of Isis' patent estate, which includes more than 1,600 issued patents worldwide and broadly covers the design and use of RNA-containing drugs. The Crooke patent estate is owned by Isis and licensed co-exclusively to Alnylam for RNAi drugs, and exclusively licensed to Regulus T
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SOURCE Isis Pharmaceuticals, Inc.; Alnylam Pharmaceuticals, Inc.
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