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Isis Receives $1.25 Million Milestone Payment From iCo for Initiation of Phase 1 Study of iCo-007
Date:10/9/2007

CARLSBAD, Calif., Oct. 9 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) today announced that it has received a $1.25 million milestone payment in the form of equity securities in iCo Therapeutics. The milestone was related to the initiation of Phase 1 clinical trials of iCo-007, a drug licensed to iCo by Isis in 2005 for the treatment of various eye diseases, including diabetic macular edema.

"Because our antisense technology enables us to rapidly discover so many highly selective antisense drugs to diverse and important disease targets, we are not able to invest in the development of every promising drug candidate. By licensing drugs at various points in development, we can continue to expand the scope and value of our external pipeline in therapeutic areas that are outside of our key focus, as evidenced by this latest clinical milestone from iCo," said C. Frank Bennett, Ph.D., Senior Vice President of Research at Isis Pharmaceuticals, Inc. "We are enthusiastic about the potential for iCo-007 as a treatment for diabetic macular edema."

About iCo-007

Designed and discovered by Isis, iCo-007 is a second-generation antisense drug that inhibits the production of c-Raf kinase, an enzyme associated with the formation of new and often abnormal or fragile blood vessels in the eye. Blood vessel breakage and leakage can contribute to vision loss, and iCo-007 is expected to decrease swelling in the retina and related visual impairment by decreasing the signaling of various growth factors such as VEGF that signal through the c-Raf kinase / MAP kinase pathway.

About Isis Pharmaceuticals, Inc.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its prod
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SOURCE Isis Pharmaceuticals, Inc.
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