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Isis Pharmaceuticals to Present at the J.P. Morgan Healthcare Conference
Date:1/8/2009

CARLSBAD, Calif., Jan. 8 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced that the Company will present at the 27th Annual J.P. Morgan Healthcare Conference in San Francisco, CA. Stanley T. Crooke, M.D., Ph.D., Chairman and CEO of Isis, will provide an overview of the Company and an update on recent clinical and business activities.

The presentation will begin at 11:30 a.m. PT (2:30 p.m. ET) on Monday, January 12, 2009. To access the live audio webcast, log on to www.isispharm.com. In addition to the live webcast, the presentation will be archived for a limited time on the Company's Web site.

About Isis Pharmaceuticals, Inc.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Isis is a joint owner of Regulus Therapeutics Inc., a joint venture focused on the discovery, development and commercialization of microRNA therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are commercializing. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,600 issued patents worldwide. Additional information about Isis is available at www.isispharm.com.

This press release includes forward-looking statements regarding Isis Pharmaceuticals' business, the finan
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SOURCE Isis Pharmaceuticals, Inc.
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