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Isis' Partners Present Clinical Data on Antisense Drugs at the American Society of Clinical Oncology
Date:6/2/2008

81308 for Phase 2 studies where LY2181308 will be evaluated in combination with other oncology agents.

"The progress our partners are making with our antisense drugs demonstrate the potential of antisense technology to provide new, first-in-class treatment options to treat a variety of cancers. Antisense drugs are highly selective for their targets which minimizes the off target interactions that are responsible for so many toxicities observed with traditional drugs in oncology studies," said Brett Monia, Ph.D., Vice President of Drug Discovery Research at Isis Pharmaceuticals. "The encouraging safety profiles observed in both Lilly's and OncoGenex's studies support further clinical evaluation of both drugs."

OGX-011 and LY2181308 are part of Isis' cancer portfolio of first-in-class drugs, which act upon biological targets associated with cancer progression and/or treatment resistance. The distribution of antisense drugs to tumor cells and the high degree of specificity of these drugs to their target make them attractive new treatment options for a broad range of cancers.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Ibis Biosciences, Inc., Isis' majority-owned subsidiary, is developing and commercializing the Ibis T5000(TM) Biosensor System, a revolutionary system to identify infectious organisms. Isis is a joint owner of Regulus Therapeutics LLC, a joint venture focused on the discovery, development and commercialization of microRNA therapeutics. As an innovator in RNA-based drug discovery and development, Isis is the owner or ex
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SOURCE Isis Pharmaceuticals, Inc.
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