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Isis' Partners Present Clinical Data on Antisense Drugs at the American Society of Clinical Oncology
Date:6/2/2008

CHICAGO and CARLSBAD, Calif., June 2 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that two of the Company's partnered oncology drugs were highlighted during the American Society of Clinical Oncology (ASCO) meeting. Data from both drugs highlighted positive activity that supports the continuation of clinical development, and both drugs were well tolerated up to very high doses. Results from Eli Lilly's Phase 1 clinical trial evaluating LY2181308 in patients with cancer and updated data from OncoGenex's Phase 2 trial evaluating OGX-011 in patients with hormone refractory prostate cancer (HRPC) were presented yesterday, June 1, at the annual ASCO meeting in Chicago. Both Lilly and OncoGenex are developing additional anticancer drugs discovered by Isis.

In both presentations, antisense drugs being developed by Isis' partners OncoGenex and Lilly continue to demonstrate the potential of antisense technology to treat multiple cancers. OncoGenex presented Phase 2 data on OGX-011 demonstrating better than expected survival results in combination with chemotherapy, reduction in levels of clusterin (the target of OGX-011), durable reductions in pain, and a decline in PSA, a protein that is often elevated in patients with prostate cancer. Encouraging data from this trial support initiation of registration trials required for product approval. OGX-011 was jointly discovered and is being co-developed by Isis and OncoGenex. Lilly presented first-in-human data from LY2181308 that showed the drug distributed to tumor cells with evidence of reduced survivin protein levels in tumor cells, LY2181308's target and one of the most commonly elevated proteins in cancer. Lilly has selected a dose of 750 mg/week of LY21
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SOURCE Isis Pharmaceuticals, Inc.
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