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Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO
Date:6/1/2009

cer. The new data confirmed that LY2181308 penetrates tumor tissue and reduces survivin mRNA and protein levels in tumor cells. In addition, Dr. Azeem Saleem, CRUK Senior Clinical Research Fellow, University of Manchester, presented results of a pharmacokinetic study of LY2181308 in patients with cancer. Using state-of-the-art imaging techniques to assess radiolabeled LY2181308 distribution in humans, Dr. Saleem reported that LY2181308 effectively penetrated tumor tissues. LY2181308 is currently being evaluated in two separate Phase 2 studies in patients with relapsed or refractory acute myeloid leukemia, and as a combination therapy in patients with hormone refractory prostate cancer.

Information in this press release is based upon data reported by Isis' drug development partners. Isis has not independently reviewed the clinical results described in this release, but has relied in its partner's statements entirely.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Isis and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microRNA therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are commercializing. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,600 issued patents worldwide. Additional information about Isis is available at

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
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