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Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO
Date:6/1/2009

ORLANDO, Fla. and CARLSBAD, Calif., June 1 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that Isis' collaborators presented new clinical data on drugs in Isis' partnered oncology franchise at this year's American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Florida. In total, four presentations were featured on three drugs in Isis' oncology pipeline, including results from a Phase 2 study of OGX-011 in patients with advanced metastatic prostate cancer and Phase 1 study of OGX-427 in patients with a variety of cancers. OGX-011 and OGX-427 are antisense drugs co-discovered by Isis and OncoGenex (Nasdaq: OGXI) and Isis licensed its rights to OGX-011 to OncoGenex Pharmaceuticals, Inc. In addition, new results from a Phase 1 trial evaluating LY2181308, an antisense drug discovered by Isis and licensed to Eli Lilly and Company, in patients with cancer were also presented. Both Lilly and OncoGenex are also developing additional anti-cancer drugs in Isis' oncology franchise.

"Oncology is one of the many different therapeutic applications of our technology. Our drug discovery platform offers us virtually unlimited opportunities to expand the scope of diseases we can treat with antisense drugs," said Brett Monia, Ph.D., Vice President of Drug Discovery and Corporate Development at Isis Pharmaceuticals. "We are encouraged by the progress our partners are making with the four anti-cancer drugs in our pipeline. The positive data our partners have reported plus the exciting work from our research efforts on new anti-cancer targets have compelled us to reinvigorate our internal cancer program. We expect to have exciting new cancer drugs to enter development in the next 12 to 18 months."


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SOURCE Isis Pharmaceuticals, Inc.
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