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Isis Announces ISIS 333611 Granted Orphan Drug Status for Treatment of ALS
Date:12/13/2007

of SOD1 extended survival of rats that show many features of ALS. The ALS Association and the Muscular Dystrophy Association are providing funding for IND-enabling studies of ISIS 333611.

About Orphan Drug Designation

The Orphan Drug Act provides for economic incentives to encourage the development of drugs for diseases affecting fewer than 200,000 people in the United States. Orphan drug designation entitles Isis Pharmaceuticals to seven years of U.S. market exclusivity for ISIS 333611 for the treatment of patients with familial ALS.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Ibis Biosciences, Inc., Isis' wholly owned subsidiary, is developing and commercializing the Ibis T5000(TM) Biosensor System, a revolutionary system to identify infectious organisms. Isis is a joint owner of Regulus Therapeutics LLC, a joint venture focused on the discovery, development and commercialization of microRNA therapeutics. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,500 issued patents worldwide. Additional information about Isis is available at http://www.isispharm.com.

This press release includes forward-looking statements regarding the development, therapeutic potential and safety of ISIS 333611. Any statement describing Isis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement, including those statements that are descr
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SOURCE Isis Pharmaceuticals, Inc.
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