Navigation Links
Is your migraine preventive treatment balanced between drugs' benefits and harms?
Date:4/17/2013

Migraine headaches are a major cause of ill health and a reduced quality of life. Some individuals suffer from a frequent and severe migraine problem which means that they require regular medication to try and prevent them. A new review of the medications, which may help to prevent episodic migraines, appears in the Journal of General Internal Medicine, published by Springer. The authors, Tatyana Shamliyan from the University of Minnesota School of Public Health, and her colleagues, compare published research on the drugs available to find those which offer the best migraine prevention coupled with the fewest adverse side-effects.

Preventive treatments for migraines aim to reduce the number of migraines suffered by fifty percent. There are a number of different drugs commonly used, all of which may cause some side effects. The researchers carried out a review of studies which tested how well the different types of drugs worked and also their acceptability in terms of adverse effects suffered. The studies used enrolled mostly middle aged women with episodic migraine who suffered an average of five monthly migraine attacks.

The authors found that all approved drugs used in the reviewed trials worked better than placebo in reducing monthly migraine attacks. They all demonstrated similar effects in that they prevented half or more migraines in 200 to 400 patients per 1000 treated. Off-label anti-epilpetics and anti-depressants appeared to cause the most bothersome side effects which usually resulted in the medication being stopped. Off-label beta-blockers and angiotensin-inhibiting drugs caused the fewest side-effects. (Off-label drugs are drugs which have not been approved by the Food and Drug Administration for a specific condition).

The American Academy of Neurology and the American Headache Society currently recommend two types of anti-epileptic drug and two beta-blockers for adult migraine prevention. These guidelines do not consider the balance between the effectiveness and harms of the drugs they recommend. As well as the increased occasion of immediate side effects with anti-epileptics, there is also evidence from other studies that with long-term use they can cause sexual problems such as impotence which would also deter long-term adherence.

Shamliyan and her colleagues suggest that future studies should examine the effects of the approved as well as the off-label drugs, taking into consideration patient demographics, family history of migraine, other illnesses and response to prior treatments. They also suggest that vigilance should be increased to monitor any adverse effects of current migraine-preventing drugs. Only once the necessary evidence is available, will migraine sufferers be given the best possible hope of a better quality of life with a preventive treatment that is more pro than con.


'/>"/>

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer
Source:Eurekalert

Related medicine news :

1. Dr. Ken Reed and Reed Migraine Centers Hosts New York Migraine Treatment Seminar
2. Colic May Be Linked to Childhood Migraine, Study Says
3. Migraine triggers tricky to pinpoint
4. Causes of migraines nearly impossible to determine
5. Brain Differences Seen in People With Migraines
6. Battery-Operated Skin Patch Offers New Option for Migraine Sufferers
7. MRI shows brain abnormalities in migraine patients
8. Blood levels of fat cell hormone may predict severity of migraines
9. Migraine Treatment Centers of America Welcomes Chronic Migraine Specialist in Phoenix, AZ
10. Nerve-Stimulating Device Might Ease Migraines
11. No Proof Drugs Ease Kids Migraines: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
Breaking Medicine Technology: