Navigation Links
Is your hemoglobin 'trending'?
Date:8/3/2010

Anemia, a common blood disorder characterized by low hemoglobin levels, has long been associated with those suffering from colorectal cancer. But researchers at Tel Aviv University have discovered that, more than a symptom of active disease, low hemoglobin levels can actually indicate a potential for colon cancer years before it's diagnosed.

Graduate student Inbal Goldshtein, who works with Dr. Gabriel Chodick and Dr. Varda Shalev of Tel Aviv University's School of Public Health and Maccabi Healthcare Services' Department of Medical Informatics, says that paying close attention to routine blood test results can be an effective screening system for colon cancer which, when diagnosed early enough, can be treated effectively. More than 50,000 people in the U.S. will die from colon cancer in 2010. Better screening could significantly reduce those numbers, Goldshtein says.

The study, recently published in the European Journal of Cancer Prevention, shows that most patients with colon cancer have a history of consistently declining hemoglobin levels up to four years before being diagnosed with the disease. Previously, says Goldshtein, researchers only looked for a sharp decrease in hemoglobin levels as a symptom of colon cancer. But Goldshtein and her fellow researchers have discovered that it's the continuous long-term decline that may announce the onset of cancer. A declining trend of more than 0.28 grams per decilitre every six months over a four-year period was observed and may serve as a warning of illness on the horizon.

An important downward trend

Taking into account the correlation between anemia and colorectal cancer, the team was keen to discover if a decline in hemoglobin levels could be detected prior to the critical stages of the disease ― something no researcher had yet attempted to quantify. Over 3,000 patients suffering from colorectal cancer participated in the study; they were compared with 10,000 control cases without colorectal cancer. Goldshtein and her fellow researchers looked at data from each participant's blood tests over a ten-year period, retrieved from the computerized database of Maccabi Healthcare Services.

Though hemoglobin levels may vary in every human being as a result of aging, a distinct trend was discovered among study participants who had been diagnosed with colorectal cancer during the study period. Approximately four years prior to their diagnoses, their blood tests began to show a continuous decline in hemoglobin levels.

For the most part, says Goldshtein, these warning signs went unnoticed. "In practice, a doctor will look at the final results, and see if the hemoglobin levels are within a normal range," she explains. "But this is not accurate enough. It is important to look at the continuing trend of each individual. If a person experiences a consistent decline relative to his own average level, it may be cause for concern."

Participants of the study with colorectal cancer experienced a sharp decline in hemoglobin levels, but because the declines did not put them outside the normal range, no red flags were raised.

A new algorithm for the average physical

The benefit of this screening process is that can be part of an average physical. Current testing for colorectal cancer is often expensive and unpleasant. There is also a very low compliance rate among patients, she adds.

The next step, says Dr. Shalev, is to create an algorithm which will automatically detect suspicious declines in hemoglobin levels, advising physicians to send their patients for further testing. Ideally, she notes, the Tel Aviv University team will develop a computer program that will display warnings when there is cause for concern.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Is your hemoglobin 'trending'?
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th ... Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, ... The fun run is geared towards children of all ages; it is a non-competitive, ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... ... 2017 , ... HMP , a leader in healthcare events and education, today ... Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & ... award competition recognizes editorial and design excellence across a range of sectors. This year’s ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 ... performance ratings for global supply chains, has published the first annual edition ... CSR performance of more than 20,400 companies evaluated by EcoVadis, based on ... 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
(Date:9/9/2017)... , Sept. 8, 2017 Dealmed Medical ... independent supplier of medical equipment, supplies, drugs, vaccines, and ... has entered into an agreement to acquire Vantage Medical ... based in Holtsville, New York . ... in supplying new and emerging medical practices, will operate ...
Breaking Medicine Technology: