Navigation Links
Is there any association between COX2 and colon cancer?
Date:5/22/2009

Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to reduce the risk of colon cancer, act directly on cyclooxygenase-2 (COX2) and reduce its activity. Population studies have found an association of inherited variations in the COX2 gene with colon cancer risk, but others were unable to replicate this finding. Similarly, variations in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) gene, which is also known to be key in the metabolism of NSAIDs, have been shown to modify the effect of NSAIDs on developing colon polyps, a precursor of colon cancer, but these modifications of NSAID effects have not been observed in risk of colon cancer.

A research article to be published on May 14, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Li from Case Western Reserve University examined the association of variants of the COX2 and UGT1A6 genes, and their interaction with NSAID consumption, on risk of colon cancer in attempt to more fully understand the relationship between genetic variation and the protective effect of NSAIDs on colon cancer risk.

They found that no single nucleotide polymorphisms (SNPs) in either gene were individually statistically significantly associated with colon cancer, nor did they statistically significantly change the protective effect of NSAID consumption. Like others, the authors were unable to replicate the association of variants in the COX2 gene with colon cancer risk (P > 0.05), and they did not observe that these variants modify the protective effect of NSAIDs (P > 0.05). Their study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. CIGNA Group Insurance Shows Consumers Theres More to Life Through a New Consumer Education Toolkit
2. Is there really a mommy gene in women?
3. Young Twin Cities Boy Shows There is Life After Cancer
4. Spectranetics Receives Reimbursement Approval in Belgium for Lead Removal and Peripheral Atherectomy Products
5. Theres More Than Turkey Behind Holiday Yawns
6. Is there a developmental component to the risk for depression?
7. Pelosi on Global HIV/AIDS Bill: There is a Moral Imperative to Combat This Epidemic
8. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
9. Let there be light
10. AZO Answers the Burning Question: Whats Up Down There?
11. Pathway Medical Technologies Awarded New Patent for Pathway PV(TM) Atherectomy System for Improved Differential Cutting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 24, 2014 Verde Pointe Dental Associates 2014 ... "Last years homemade Christmas sweater lit up, but this ... 2014 winner is Tandy Wilson for the second year in ... says Kirk Kimmerling DDS. "She took pictures of the entire ... sweater." , "Every year I enjoy stopping by ...
(Date:12/24/2014)... “ Relax Melodies ” was featured on NewsWatch ... latest and coolest mobile applications on the iOS, Android, ... and host of NewsWatch, conducted the app review and ... they can fall asleep. , According to the National ... some sort of difficulty sleeping. Since that’s a huge ...
(Date:12/24/2014)... California (PRWEB) December 24, 2014 Final ... of the ProDenoise from Pixel Film Studios. , “The ProDenoise ... or grain in their footage,” said Christina Austin, CEO of ... in any Final Cut Pro X editors toolbox.” , Final ... noise or grain in their footage with ProDenoise from Pixel ...
(Date:12/24/2014)... Kathleen Doheny HealthDay Reporter ... diet of fast food might hurt your child in the ... fast food in fifth grade lagged behind by eighth grade, ... than 8,500 U.S. students. "The largest effects were found ... said study leader Kelly Purtell, assistant professor of human sciences ...
(Date:12/24/2014)... 2014 (HealthDay News) -- Longer and colder body cooling does ... brain damage from a lack of oxygen, a new study ... with this condition -- called hypoxic ischemic encephalopathy -- can ... Celsius (92.3 Fahrenheit) for 72 hours, experts say. Research ... of animals, so this study examined if the same would ...
Breaking Medicine News(10 mins):Health News:Verde Pointe Dental Associates Announces the 2014 Ugly Sweater Holiday Contest Winner 2Health News:An Application to Help with Insomnia was Featured on NewsWatch Television on December 19, 2014 2Health News:Pixel Film Studios released the ProDenoise plugin for Final Cut Pro X today. 2Health News:Can Fast Food Hinder Learning in Kids? 2Health News:Greater Cooling of Oxygen-Deprived Infants Fails to Improve Survival 2
... shows young donors experience a lower rate of adverse reactions ... , LAKE ZURICH, Ill., June 23 Fenwal Inc. ... Richard J. Benjamin, M.D., Ph.D., chief medical officer of the ... relative safety of automated two-unit red cell procedures and manual ...
... Healthcare, Inc. (PDHI) launches the ConXus Profile Third-Party Health ... merge historical data from third-party HRAs with data collected ... may be reluctant to switch their current HRA data ... health information accumulated over time. PDHI has developed ...
... say , TUESDAY, June 23 (HealthDay News) -- Women ... developing brain lesions, a new study has found. , Whether ... cognition, however, remains unknown, the researchers added. , "Migraine used ... occurred, but these data suggest that there may be tissue ...
... to maintain a healthy weight, , TUESDAY, June 23 (HealthDay ... increases the risk for pancreatic cancer, and obesity in middle ... new study finds. , Pancreatic cancer is the fourth leading ... United States. As the number of people who are overweight ...
... ... threaten financial and emotional health -- and your life, says cancer survivor Jo ... of health insurers. She thought the healthcare system might have changed since she ... serious condition. Godfrey knows she is not alone, and she is ...
... ... needs of our nation,s over-the-road drivers and will showcase their efforts at The Great West ... ... Lifeclinic International, Inc., the world,s leading manufacturer and distributor of automated blood pressure monitors ...
Cached Medicine News:Health News:Fenwal to Host Webinar on the Safety of 2-Unit Red Cell Collections From Young Donors 2Health News:Fenwal to Host Webinar on the Safety of 2-Unit Red Cell Collections From Young Donors 3Health News:PDHI Launches ConXus Profile Third-Party Health Risk Assessment Data-Load Process 2Health News:Migraine With Aura May Lead to Brain Lesions 2Health News:Migraine With Aura May Lead to Brain Lesions 3Health News:Obesity While Young Boosts Pancreatic Cancer Risk 2Health News:Obesity While Young Boosts Pancreatic Cancer Risk 3Health News:Insurance May Be Hazardous to Your Health: "They Figured It Was Cheaper to Kill Me" 2Health News:Insurance May Be Hazardous to Your Health: "They Figured It Was Cheaper to Kill Me" 3Health News:Insurance May Be Hazardous to Your Health: "They Figured It Was Cheaper to Kill Me" 4Health News:Lifeclinic Teams Up With Trucking Industry to Promote Health and Wellness to Over-the-Road Professionals 2Health News:Lifeclinic Teams Up With Trucking Industry to Promote Health and Wellness to Over-the-Road Professionals 3
(Date:12/24/2014)... 2014  Advanced Medical Isotope Corporation ("AMIC") (OTCQB: ADMD), ... the development of brachytherapy devices and medical isotopes ... it has filed a de novo ... for marketing clearance for its patented Y-90 RadioGel(TM) ... Food, Drug and Cosmetic Act (the "Act").  ...
(Date:12/24/2014)... 24, 2014 LifeScienceIndustryResearch.com ... Disposable Syringe Industry of 178 pages providing ... intelligence library. The 2014 Market ... is a professional and deep research report ... analysis, the report introduces Disposable Syringe basic ...
(Date:12/24/2014)... Ohio , Dec. 23, 2014   ... treatment decision support to healthcare providers for behavioral ... it has secured $30 million in equity financing ... Virginia C. Drosos , President and Chief Executive ... clinical adoption and development of Assurex Health,s ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4
... 2011 The CAQH® Universal Provider Datasource® (UPD®) ... as the go-to resource for complete and reliable ...  Three out of five licensed and practicing physicians ... service. About 7,000 additional providers are registering each ...
... 2011 Instrumentation Laboratory (IL) today announced the appointment ... effective May 1, 2011.  Mr. Benet began his career ... Vice President of Worldwide Marketing, Sales and Service.   ... Josep Manent who served as CEO since 1999.  Under ...
Cached Medicine Technology:900,000 Healthcare Providers Now Part of CAQH Universal Provider Datasource 2900,000 Healthcare Providers Now Part of CAQH Universal Provider Datasource 3Instrumentation Laboratory Appoints Ramon E. Benet New Chief Executive Officer 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: