Navigation Links
Is somatic hypersensitivity a predictor of irritable bowel syndrome?
Date:7/22/2009

Although visceral hypersensitivity is considered a hallmark feature of IBS, conflicting evidence exists regarding somatic hypersensitivity in this patient population. Several investigators have found no evidence for heightened somatic pain sensitivity in IBS patients. Also, others have reported similar cold presser pain tolerance in IBS patients and controls. These conflicting findings may result from differing somatic pain testing procedures. Previous studies have explored the correlates of visceral hypersensitivity among patients with IBS. To further evaluate somatic hyperalgesia among patients with IBS, the authors evaluated thermal pain sensitivity among patients with diarrhea-predominant IBS (D-IBS) vs constipation-predominant IBS (C-IBS) compared with healthy subjects.

A research led by G Nicholas Verne from United States addressed this issue. The article is to be published on July 14, 2009 in the World Journal of Gastroenterology. A total of 42 cases with D-IBS and 24 with C-IBS, and 52 control subjects were collected in the study. Their thermal pain hypersensitivity were examined Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm 3 cm surface area. Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits. The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.

The research revealed controls were less sensitive than C-IBS and D-IBS with no differences between C-IBS and D-IBS for HPTh and HPTo. Thermal hyperalgesia was present in both groups of IBS patients relative to controls, with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.

A unique finding of this study is that the authors detected a strong relationship between heat pain measures and Functional Bowel Disease Severity Index (FBDSI) scores. IBS patients with high FBDSI scores had the highest thermal pain sensitivity compared to those IBS patients with low to moderate FBDSI scores.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Converting adult somatic cells to pluripotent stem cells using a single virus
2. Quality of life: most important predictor of survival for advanced NSCLC patients
3. Biomarker may be an early predictor of advanced breast cancer
4. Possible genetic predictor for response to lithium augmentation in depressed patients
5. Predictors of inaccurate online breast cancer information
6. Disability Stronger Predictor of Longevity Than Disease Is
7. Body image is stronger predictor of health than obesity, says Mailman School of PH study
8. OHSU cancer institute researcher discovers new predictor of prostate cancer recurrence
9. UT Southwestern researchers investigate predictors for sickle-cell-anemia complications
10. Leicester medical team announces predictor for pregnant women who may have miscarriages
11. MRI Can Be Predictor of Post-Treatment Prostate Cancer Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... in Beverly Hills, California, will be included in the 2016 “Guide to America’s ... exceptional professionals based on the amalgamation of their education, experience, and professional associations. ...
(Date:12/2/2016)... Wilmington, Delaware (PRWEB) , ... December 02, 2016 ... ... has released a new version of its SaaS LIMS, CloudLIMS Lite. CloudLIMS Lite ... from sample entry through labeling, storing, shipping and disposal. The new version is ...
(Date:12/2/2016)... ... December 02, 2016 , ... Sourced from the Isbre Springs beneath the ... its unmatched natural purity of just 6 ppm TDS (Total Dissolved Solids) in addition ... has been available in several ShopRite and FoodTown stores in NJ and received rave ...
(Date:12/2/2016)... ... , ... "Pro3rd Accents Volume 2 is a set of 30 accented lower ... just a few clicks of the mouse," said Christina Austin - CEO of Pixel ... from various styles with accented animations, rigid boxes, simplistic lines, and more. In Addition, ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... to build intelligent, connected applications, was named the best Sales Team of 2016 ... winner announcement was made today by the Software & Information Industry Association (SIIA), ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... , Dec. 3, 2016  Findings from a ... of CTL019, an investigational chimeric antigen receptor T ... and young adult patients with B-cell acute lymphoblastic ... oral session at the 58th American Society of ... 4:00-5:30 p.m.). The global Phase II study found ...
(Date:12/2/2016)... -- Persistence Market Research (PMR) delivers key ... titled, "Global Market Study on Cardiac Pacemaker: North America Regional ... 2016 and 2024". The global cardiac pacemaker market was valued ... likely to decline to US$ 3923.8 Mn by 2024. ... is anticipated to exhibit a declining CAGR of -0.5% ...
(Date:12/2/2016)... 2016 According to a ... by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical ... Nephrology, Infectious Diseases) - Forecast to 2021" published ... USD 60.22 Billion in 2016. This market is ... during the forecast period (2016-2021) to reach USD ...
Breaking Medicine Technology: