Navigation Links
Is sildenafil safe in cirrhosis patients?
Date:11/11/2008

Sildenafil is valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease through inhibition of the type-5 phosphodiesterase. The type-5 phosphodiesterase is also present in human mesenteric arteries. The effect of sildenafil on splanchnic blood flow and portal hypertension remains essentially unknown.

The research team led by Otto Clemmesen from Denmark addresses this question and this will be be published on October 28; 2008 in the World Journal of Gastroenterology.

Ten patients with biopsy proven cirrhosis (5 females/5 males, mean age 54 8 years) and the hepatic venous pressure gradient (HVPG) above 12 mmHg were studied after informed consent. Measurement of splanchnic blood flow and the HVPG during liver vein catheterization were done before and 80 min after oral administration of 50 mg sildenafil. Blood flow was estimated by use of indocyanine green clearance technique and Fick's principle, with correction for non-steady state.

They found that the plasma concentration of sildenafil was 222 136 ng/mL 80 min after administration. Mean arterial blood pressure decreased from 77 7 to 66 12 mmHg, P = 0.003, while the splanchnic blood flow and oxygen consumption remained unchanged at 1.1 0.71 L/min and 2.3 0.6 mmol/min, respectively. Also the HVPG remained unchanged (18 2 vs 16 2 mmHg) with individual changes ranging from -8 to +2 mmHg. In 7 patients HVPG decreased and in 3 it increased.

The result indicated that sildenafil do not induce any profound clinically relevant changes in splanchnic blood flow, oxygen consumption and HVPG in patients with cirrhosis. Phosphodiesterase type-5 inhibition is of no use as a therapeutic agent for alleviating portal hypertension in patients with chronic end-stage liver disease.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Alcoholics With Cirrhosis Have More Brain Damage
2. Primary biliary cirrhosis more severe in African-American and Hispanic patients
3. New research may lead to earlier diagnosis and treatment of primary biliary cirrhosis in families
4. Noninvasive tests for cirrhosis may help to avoid liver biopsy
5. Amsterdam Molecular Therapeutics Initiates Program for Late Stage Liver Cirrhosis and Reports Strong Progress in AMT-011 With Trial Fully Recruited and European and US Submission On Track for First Half of 2008
6. Baclofen Aids Abstinence in Alcoholics With Cirrhosis
7. Research Offers Promise for Cirrhosis Treatment
8. Cause of effectiveness discovered for a cirrhosis treatment useful in 40 percent of patients
9. An effective strategy for inhibition of cirrhosis
10. Does 1q31.1-32.1 harbor a tumor suppressor gene related to Chinese SCC patients?
11. Medicare Fraud: How Many Dead Doctors Does it Take to Prescribe $90 Million in Medical Equipment for Medicare Patients?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... a one-day corporate governance program for mid-market executives as a kick-off to the ... held Sunday, Sept. 24, 2017 on the University of Pennsylvania campus, followed by ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... insurance management and financial planning assistance to clients in southern Montana, is announcing ... offered by Zoo Montana. , The outreach programs offered by Zoo Montana provide ...
(Date:6/27/2017)... ... June 27, 2017 , ... Excel Medical, ... Finnegan to the position of Executive Vice President, Sales and Marketing. Finnegan is ... telehealth and medical device sales leadership. He has received industry recognition for innovations ...
(Date:6/27/2017)... , ... June 27, 2017 , ... ... solution for many of the health care industry’s hospitals and provider groups, has ... financing portal for select customers. Parasail Health is a San Francisco health-finance startup ...
(Date:6/27/2017)... ... 27, 2017 , ... A January 18th article on medGadget reports ... billion by the year 2024 according to a new report. The article also notes ... from titanium. Los Angeles area clinic Beverly Hills Periodontics & Dental Implant Center says ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... INDIANAPOLIS , June 9, 2017 /PRNewswire/ ... diabetes. In a further effort to help spread lessons ... this condition, the International Diabetes Federation (IDF) and Eli ... come together for the second phase of the Bringing ... (BRIDGES 2), reaffirming their commitment to helping people with ...
(Date:6/8/2017)... Texas , June 8, 2017 /PRNewswire/ ... a leading developer and manufacturer of diagnostic ... announced today that Cressey & Company LP ... firm, has completed a growth-focused investment in ... a majority ownership position from selling shareholder, ...
(Date:6/7/2017)... , June 6, 2017  Diplomat Specialty Infusion Group, a brand ... environment to its Iowa location. ... now features an ISO 7 cleanroom—the standard needed to ... with a low level of pollutants. ... nutrition consumers and better serve our Iowa ...
Breaking Medicine Technology: