Navigation Links
Is increased Slug expression associated with the progression to esophageal cancer?
Date:3/13/2008

Real-time reverse transcription-polymerase chain reaction (RT-PCR), semi-quantitative immunohistochemistry and tissue array reveal that the progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing.

This study, performed by a team led by Dr C Tselepis, is described in a research article published in the February 21, 2008 issue of the World Journal of Gastroenterology.

The loss of cell-cell adhesion is a common event in nearly all epithelial malignancies and is associated with increased cellular invasiveness and metastasis. The main mechanism by which cell-cell adhesion is repressed in oesophageal adenocarcinoma is thought to be through the repression of the cell adhesion molecule E-cadherin. This study reports that a potential mechanism by which E-cadherin could be silenced is through over expression of the protein Slug, a protein which has been shown to directly repress E-cadherin in other epithelial cancers. An understanding of how this protein is over expressed and how to block its expression may provide a platform for therapeutic intervention in the treatment of patients with oesophageal cancer.

Research lead by Dr C Tselepis has investigated the expression of Slug, Snail and Twist in the progression of Barretts metaplasia to adenocarcinoma. It has also demonstrated that the protein Slug is over expressed in oesophageal adenocarcinoma and in vitro can repress E-cadherin expression.

In the view of the author, this novel work opens up a potential area for therapeutic intervention. By understanding how the protein Slug is over expressed it may be possible to block its expression and potentially repress any detrimental downstream effects including the loss of E-cadherin.

Whilst this work clearly describes the expression profile of Slug in the malignant progression and that in vitro it has the potential to repress E-cadherin, whether this occurs in vivo remains undetermined and clearly requires further delineation.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Increased distance to physician associated with thicker skin cancer at diagnosis
2. Methamphetamine study suggests increased risk for HIV transmission
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Minorities more likely to have sleep durations associated with increased mortality
5. Teens who see more smoking in movies may have increased risk of becoming established smokers
6. Study shows adverse drug events reported to the FDA have significantly increased
7. New Case Study Details How an Illinois Hospital Created a Safe Lifting Team that Dramatically Reduced Injuries, Increased Staff Satisfaction
8. Maternal depression and controlling behavior associated with increased stress response in infants
9. BioProcessors Launches SimCell(TM) Services to Meet Increased Customer Demand
10. Both short and long sleep is associated with increased mortality
11. New Study Shows Lower Costs, Increased Consumer Engagement in Account-Based Health Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... February 06, 2016 , ... ... , MEDIA ADVISORY: 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE & ... nurses in the world with an estimated 5000 perioperative nurses in attendance ...
(Date:2/5/2016)... SARASOTA, Florida (PRWEB) , ... February 05, 2016 , ... ... an event he has completed every year since it started in 2003. This year, ... attracting the attention of fellow runners and NBA team the Miami Heat. , This ...
(Date:2/5/2016)... Minneapolis, MN (PRWEB) , ... February 05, 2016 , ... ... p.m. at the Day Block Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will ... , Larry Schneiderman, owner of Schneiderman’s Furniture, lives with Parkinson’s disease and is the ...
(Date:2/5/2016)... ... 05, 2016 , ... After years as an active staff surgeon and having ... surgeon Dr. Wayne Carman transitioned to chief of the Division of Plastic Surgery at ... term as chief and began a second three-year term in January of 2016. , ...
(Date:2/5/2016)... ... , ... Regular gym users know the routine: each January, they see a ... treadmills. It’s a predictable trend. After the excesses of November and December, people make ... joining gyms, starting new walking or running routines, or signing up for Zumba. And ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... York , February 5, 2016 ... Transparency Market Research report states that the global active ... 2014 and is predicted to reach US$185.9 bn by ... of 6.50% from 2014 to 2020. The title of ... Chemical/Biological, Captive/Contract Manufactured, by Geography, and by Therapeutic Area) ...
(Date:2/5/2016)... MELVILLE, N.Y. , Feb. 5, 2016  Henry ... of health care products and services to office-based dental, ... has entered into an agreement to acquire a majority ... dental supplies and equipment in Brazil ... Headquartered in Blumenau, Brazil, Dental Cremer is the dental ...
(Date:2/4/2016)... , Feb. 4, 2016 For hospitals considering ... those already participating in the program, the Health Resources ... to as the , Mega-Guidance , could have significant ... is published in September 2016. Essential Insights ... Service Marketing , summarizes the Mega-Guidance,s key proposed changes, ...
Breaking Medicine Technology: