Navigation Links
Is increased Slug expression associated with the progression to esophageal cancer?

Real-time reverse transcription-polymerase chain reaction (RT-PCR), semi-quantitative immunohistochemistry and tissue array reveal that the progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing.

This study, performed by a team led by Dr C Tselepis, is described in a research article published in the February 21, 2008 issue of the World Journal of Gastroenterology.

The loss of cell-cell adhesion is a common event in nearly all epithelial malignancies and is associated with increased cellular invasiveness and metastasis. The main mechanism by which cell-cell adhesion is repressed in oesophageal adenocarcinoma is thought to be through the repression of the cell adhesion molecule E-cadherin. This study reports that a potential mechanism by which E-cadherin could be silenced is through over expression of the protein Slug, a protein which has been shown to directly repress E-cadherin in other epithelial cancers. An understanding of how this protein is over expressed and how to block its expression may provide a platform for therapeutic intervention in the treatment of patients with oesophageal cancer.

Research lead by Dr C Tselepis has investigated the expression of Slug, Snail and Twist in the progression of Barretts metaplasia to adenocarcinoma. It has also demonstrated that the protein Slug is over expressed in oesophageal adenocarcinoma and in vitro can repress E-cadherin expression.

In the view of the author, this novel work opens up a potential area for therapeutic intervention. By understanding how the protein Slug is over expressed it may be possible to block its expression and potentially repress any detrimental downstream effects including the loss of E-cadherin.

Whilst this work clearly describes the expression profile of Slug in the malignant progression and that in vitro it has the potential to repress E-cadherin, whether this occurs in vivo remains undetermined and clearly requires further delineation.


Contact: Jing Zhu
World Journal of Gastroenterology

Related medicine news :

1. Increased distance to physician associated with thicker skin cancer at diagnosis
2. Methamphetamine study suggests increased risk for HIV transmission
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Minorities more likely to have sleep durations associated with increased mortality
5. Teens who see more smoking in movies may have increased risk of becoming established smokers
6. Study shows adverse drug events reported to the FDA have significantly increased
7. New Case Study Details How an Illinois Hospital Created a Safe Lifting Team that Dramatically Reduced Injuries, Increased Staff Satisfaction
8. Maternal depression and controlling behavior associated with increased stress response in infants
9. BioProcessors Launches SimCell(TM) Services to Meet Increased Customer Demand
10. Both short and long sleep is associated with increased mortality
11. New Study Shows Lower Costs, Increased Consumer Engagement in Account-Based Health Plans
Post Your Comments:
(Date:6/25/2016)... California (PRWEB) , ... June 25, 2016 , ... "With ... fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... customizable and all within Final Cut Pro X . Simply select a ProHand ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
Breaking Medicine Technology: