Navigation Links
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Date:11/18/2009

Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. Valproic acid (VPA), a histone deacetylase inhibitor, has been demonstrated to facilitate the hepatic differentiation of mesenchymal stem cells. However, little is know about whether VPA could induce the hepatic differentiation of ES cells.

A research team from China reported such research and the development of a protocol for direct hepatic lineage differentiation, from early developmental progenitors to a population of mature hepatocytes, based on sequential induction with VPA and cytokines. Results showed that VPA can direct the hepatic specification of ES cells and largely participates in the differentiation of ES cells into hepatic progenitors. Further differentiation of hepatic progenitors into mature hepatocytes requires supplementation with cytokines. Their study will be published on November 7, 2009 in the World Journal of Gastroenterology.

Their research may not only be helpful for the clinical application of hepatocyte transplantation, but also provide an in vitro research model for the better investigation and understanding of the entire developmental process of hepatocytes, from ES cells to hepatic progenitors, and then to mature hepatocytes. Furthermore, as VPA is an epigenetic modulator, their results may also be of benefit to the research of mechanisms of epigenetic modifications during liver development.


'/>"/>

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Attention: Extra-hepatic manifestation of hepatitis C virus infection
2. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
3. Stem cells from umbilical cord used in the treatment of hepatic diseases
4. May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
5. Cathepsin B increases apoptosis in fulminant hepatic failure
6. Large congenital and solitary intrahepatic arterioportal
7. Are imaging features of hepatic angiomyolipoma related to its clinical setting?
8. A potential therapeutic agent for hepatic fibrosis
9. Hepatic injury in cholelithiasis and cholecystitis
10. Forever young: Differentiation blocked in tumor stem cells
11. Trigger for Stem Cell Differentiation Detailed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... Ontario (PRWEB) , ... February 05, 2016 , ... After ... Scarborough General Hospital Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned to ... Scarborough Hospital. He successfully completed his first three-year term as chief and began a ...
(Date:2/5/2016)... ... February 05, 2016 , ... The American public tends to ... may be safer than regular municipal or well water. The recent experience with lead ... Kleyne, could go a long way toward increasing public acceptance of recycled waste water ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... in the 2015 Best in KLAS: Software & Services for HIT Implementation Support ... in KLAS report independently ranks vendor performance by healthcare executives, managers and clinicians ...
(Date:2/5/2016)... CA (PRWEB) , ... February 05, 2016 , ... ... and founder of CitiDent, announces that it is now welcoming orthodontist, Dr. ... Cheng, CitiDent offers a complete range of oral health care, including general dentistry, ...
(Date:2/5/2016)... ... February 05, 2016 , ... California Mobile Kitchens , ... of their latest mobile kitchen model, featuring customizable stainless steel interiors and a ... kitchens for use anywhere in the U.S. Many of their units can be ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... February 5, 2016 --> ... report states that the global active pharmaceuticals ingredients (APIs) ... predicted to reach US$185.9 bn by 2020. It is ... 2014 to 2020. The title of the report is ... by Geography, and by Therapeutic Area) - Global Industry ...
(Date:2/5/2016)... PUNE, India , February 5, 2016 ... to a new market research report "Fetal (Labor & ... (Intrapartum & Antepartum), Warmer, Incubator, Pulse Oximeter, Phototherapy/Jaundice Management ... 2020", published by MarketsandMarkets, This report studies the global ... The market is estimated at USD 6.28 Billion in ...
(Date:2/5/2016)... -- France , Germany , ... Israel ). It includes a 10-year epidemiology forecast for ... by age and sex in these markets. GD epidemiology report is written ... high quality, transparent and market-driven, providing expert analysis of disease trends in ... , Italy , Spain , ...
Breaking Medicine Technology: