Navigation Links
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Date:11/18/2009

Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. Valproic acid (VPA), a histone deacetylase inhibitor, has been demonstrated to facilitate the hepatic differentiation of mesenchymal stem cells. However, little is know about whether VPA could induce the hepatic differentiation of ES cells.

A research team from China reported such research and the development of a protocol for direct hepatic lineage differentiation, from early developmental progenitors to a population of mature hepatocytes, based on sequential induction with VPA and cytokines. Results showed that VPA can direct the hepatic specification of ES cells and largely participates in the differentiation of ES cells into hepatic progenitors. Further differentiation of hepatic progenitors into mature hepatocytes requires supplementation with cytokines. Their study will be published on November 7, 2009 in the World Journal of Gastroenterology.

Their research may not only be helpful for the clinical application of hepatocyte transplantation, but also provide an in vitro research model for the better investigation and understanding of the entire developmental process of hepatocytes, from ES cells to hepatic progenitors, and then to mature hepatocytes. Furthermore, as VPA is an epigenetic modulator, their results may also be of benefit to the research of mechanisms of epigenetic modifications during liver development.


'/>"/>

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Attention: Extra-hepatic manifestation of hepatitis C virus infection
2. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
3. Stem cells from umbilical cord used in the treatment of hepatic diseases
4. May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
5. Cathepsin B increases apoptosis in fulminant hepatic failure
6. Large congenital and solitary intrahepatic arterioportal
7. Are imaging features of hepatic angiomyolipoma related to its clinical setting?
8. A potential therapeutic agent for hepatic fibrosis
9. Hepatic injury in cholelithiasis and cholecystitis
10. Forever young: Differentiation blocked in tumor stem cells
11. Trigger for Stem Cell Differentiation Detailed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Farmington Company today announced it ... and visual identity helping brokers, consultants and companies ... to create greater benefit communication synergies. They unveiled ... empowering customers to better leverage Farmington Company’s industry-tested ... of the rebrand is the refreshed tagline: For ...
(Date:10/1/2014)... finding from Duke Medicine suggests that some people who ... be hard-wired to gain weight when exposed to chronic ... estimated 13 percent of people, all of whom are ... could help them reduce heart disease with simple interventions ... , "Genetic susceptibility, psychosocial stress and metabolic factors act ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Between 23 ... in the U.S., according to figures from the National ... Diseases Association (AARDA), and many of them have something ... of having undiagnosed celiac disease. Gluten Free Therapeutics, ... awareness of undiagnosed celiac disease by publishing a series ...
(Date:10/1/2014)... 01, 2014 Diet Doc understands that many ... lose weight and their dieting attempts could be easily sabotaged ... hormone diet treatments into their programs as a ... see fast and effective weight loss results, it also allows ... habits to maintain their weight for the future. , Earlier ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Anti Aging ... and skin rejuvenating destination of choice, is announcing a ... October through to December. , “We’re doing this because ... possible to our top skin clinic in Toronto,” says ... do so much at Anti Aging Clinic, including laser ...
Breaking Medicine News(10 mins):Health News:Farmington Company Launches Rebrand and New Positioning 2Health News:Gene interacts with stress and leads to heart disease in some people 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2
... be releasing both Raima Database Manager (RDM) products ... version 9.1 and RDM Server will be released ... RDM,s high availability by providing replication between RDM ... provide developers of embedded systems with an easy ...
... shortened course of radiation therapy for prostate cancer ... PSA response for early-stage prostate cancer and has ... to a March 15 study in the ... journal of the American Society for Radiation Oncology ...
... and getaway destinations are affected, studies find , , SUNDAY, March ... allergies can be a burden on a family,s finances and ... to be presented in Washington, D.C., at the annual meeting ... how these common conditions can have a wide impact on ...
... Manufacturers Association issued the following statement from its president ... to President Obama,s nomination of Dr. Margaret Hamburg as ... (FDA), his nomination of Dr. Joshua Sharfstein as Principal ... a White House Food Safety Working Group:"We applaud President ...
... have exams, even if they have problems, study finds, , , ... coverage, or no health care coverage, are less likely to ... according to a new study. , The finding stems from ... part in the National Health Interview Survey from 1997 through ...
... in health care recruiting and staffing. Individuals have the choice of ... working with an established Health Career Agents office. , ... ... Agents now has three ways for qualified individuals to get involved ...
Cached Medicine News:Health News:Birdstep Technology Announces The Dual Upcoming Release Of Its Raima Database Manager Products 2Health News:Birdstep Technology Announces The Dual Upcoming Release Of Its Raima Database Manager Products 3Health News:Early results favorable for 5-day radiation treatment of early stage prostate cancer 2Health News:Child's Food Allergies Take Toll on Family Plans 2Health News:Grocery Manufacturers Association Statement Regarding President Obama's Nomination of FDA Commissioner 2Health News:Eye Care Checkups Tied to Insurance Status 2Health News:Health Career Agents Announces Three Options for Involvement in Health Care Recruiting and Staffing 2Health News:Health Career Agents Announces Three Options for Involvement in Health Care Recruiting and Staffing 3
(Date:9/30/2014)... 30, 2014 Arbor Pharmaceuticals, LLC. - ... Global Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - Product ... the Arbor Pharmaceuticals, LLC.,s pharmaceutical research and development ... the current therapeutic developmental pipeline of Arbor Pharmaceuticals, ... therapeutics assessment by drug target, mechanism of action ...
(Date:9/30/2014)... , Sept. 30, 2014  Decision Resources Group finds ... Brazil , Russia ... China (BRIC) will see robust expansion as ... favored over surgical procedures. Although revenues will be somewhat ... challenges, prolonged device approval times and demand for low-cost ...
(Date:9/30/2014)... , Sept. 30, 2014  According to their ... of cancer clinical trials is going through a ... and the work of the current clinical trial ... of ,next generation, clinical trials, which will ultimately ... The company has been recognized by ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 2Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2
... NEW YORK, Jan. 16, 2012 Reportlinker.com ... is available in its catalogue: ... Medical Devices to 2016 ... gives a thorough analysis of the refurbished ...
... Conn., Jan. 13, 2012 /PRNewswire-iReach/ -- Global Information, ... report, "Insulin Delivery Devices - Global Pipeline Analysis, Competitive Landscape ... http://photos.prnewswire.com/prnh/20120113/CG35865 ) The Insulin Delivery ... 6% to Reach $11 Billion by 2017 ...
Cached Medicine Technology:The Market Outlook for Refurbished Medical Devices to 2016 2The Market Outlook for Refurbished Medical Devices to 2016 3The Market Outlook for Refurbished Medical Devices to 2016 4Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 2Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 3Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: