Navigation Links
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Date:11/18/2009

Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. Valproic acid (VPA), a histone deacetylase inhibitor, has been demonstrated to facilitate the hepatic differentiation of mesenchymal stem cells. However, little is know about whether VPA could induce the hepatic differentiation of ES cells.

A research team from China reported such research and the development of a protocol for direct hepatic lineage differentiation, from early developmental progenitors to a population of mature hepatocytes, based on sequential induction with VPA and cytokines. Results showed that VPA can direct the hepatic specification of ES cells and largely participates in the differentiation of ES cells into hepatic progenitors. Further differentiation of hepatic progenitors into mature hepatocytes requires supplementation with cytokines. Their study will be published on November 7, 2009 in the World Journal of Gastroenterology.

Their research may not only be helpful for the clinical application of hepatocyte transplantation, but also provide an in vitro research model for the better investigation and understanding of the entire developmental process of hepatocytes, from ES cells to hepatic progenitors, and then to mature hepatocytes. Furthermore, as VPA is an epigenetic modulator, their results may also be of benefit to the research of mechanisms of epigenetic modifications during liver development.


'/>"/>

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Attention: Extra-hepatic manifestation of hepatitis C virus infection
2. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
3. Stem cells from umbilical cord used in the treatment of hepatic diseases
4. May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
5. Cathepsin B increases apoptosis in fulminant hepatic failure
6. Large congenital and solitary intrahepatic arterioportal
7. Are imaging features of hepatic angiomyolipoma related to its clinical setting?
8. A potential therapeutic agent for hepatic fibrosis
9. Hepatic injury in cholelithiasis and cholecystitis
10. Forever young: Differentiation blocked in tumor stem cells
11. Trigger for Stem Cell Differentiation Detailed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... , ... March 23, 2017 ... ... Complying with European Guidelines and the New MEDDEV 2.7/1 Rev. 4 Guidance, ... ET, http://www.fdanews.com/mdclineval                  , How will the new EU MDR language ...
(Date:3/23/2017)... ... 23, 2017 , ... News Advisory/Interview Opportunity , After six years of advocacy, ... in Europe for public health and the environment and is calling on the United ... and the overwhelming support of European citizens, the European Union (EU) will, beginning next ...
(Date:3/23/2017)... ... March 23, 2017 , ... “My Journey Through Heaven”: ... with an infinitely more profound faith of God’s promise of Heaven for His people. ... who spends each day with his wife, three children and six grandchildren living and ...
(Date:3/23/2017)... ... March 23, 2017 , ... “The Trainer”: an electrifying and ... Scotty, a fiction writer with an active imagination and an enthusiasm for action and ... the tale of Wild Bill Hart, who sat looking at the thirty-three notches that ...
(Date:3/22/2017)... , ... March 23, 2017 , ... Death anxiety is ... by profession, author Joy Nugent was inspired to write the book titled “ As ... her inward desire to make sense of what she was experiencing at the bedside ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017  Cornerstone Pharmaceuticals, Inc., a ... milestone today.  Following successful End-of-Phase I (EOP1) ... and Drug Administration (FDA), the Company has ... path forward to conduct pivotal trials of ... acute myeloid leukemia (AML) and pancreatic cancer. ...
(Date:3/23/2017)... , March 23, 2017 ... ended the trading session at 5,821.64, up 0.48%; ... to finish at 20,661.30; and the S&P 500 ... broad based as six out of nine sectors ... has initiated reports coverage on the following Medical ...
(Date:3/23/2017)... March 23, 2017 ... Enterprises Limited, gibt die Ernennung von Stuart ... bietet seinen globalen Pharmazeutikkunden eine einmalige integrierte ... wichtige Rolle für das erfolgreiche Wachstum und ... Leiter wird Herr Needleman dafür verantwortlich sein, ...
Breaking Medicine Technology: