Navigation Links
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Date:11/18/2009

Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. Valproic acid (VPA), a histone deacetylase inhibitor, has been demonstrated to facilitate the hepatic differentiation of mesenchymal stem cells. However, little is know about whether VPA could induce the hepatic differentiation of ES cells.

A research team from China reported such research and the development of a protocol for direct hepatic lineage differentiation, from early developmental progenitors to a population of mature hepatocytes, based on sequential induction with VPA and cytokines. Results showed that VPA can direct the hepatic specification of ES cells and largely participates in the differentiation of ES cells into hepatic progenitors. Further differentiation of hepatic progenitors into mature hepatocytes requires supplementation with cytokines. Their study will be published on November 7, 2009 in the World Journal of Gastroenterology.

Their research may not only be helpful for the clinical application of hepatocyte transplantation, but also provide an in vitro research model for the better investigation and understanding of the entire developmental process of hepatocytes, from ES cells to hepatic progenitors, and then to mature hepatocytes. Furthermore, as VPA is an epigenetic modulator, their results may also be of benefit to the research of mechanisms of epigenetic modifications during liver development.


'/>"/>

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Attention: Extra-hepatic manifestation of hepatitis C virus infection
2. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
3. Stem cells from umbilical cord used in the treatment of hepatic diseases
4. May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
5. Cathepsin B increases apoptosis in fulminant hepatic failure
6. Large congenital and solitary intrahepatic arterioportal
7. Are imaging features of hepatic angiomyolipoma related to its clinical setting?
8. A potential therapeutic agent for hepatic fibrosis
9. Hepatic injury in cholelithiasis and cholecystitis
10. Forever young: Differentiation blocked in tumor stem cells
11. Trigger for Stem Cell Differentiation Detailed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... (PRWEB) , ... February 18, 2017 , ... ... today provides the latest information and contact points to easily connect elderly veterans ... care, assisted living, and elder-care funding. It also conveys material on this year's ...
(Date:2/17/2017)... Nashville, TN (PRWEB) , ... February 17, 2017 ... ... Services, Inc. (ISTS) brings its educational assistance management solution to the exhibit floor ... Convention Center in Orlando, Fla. , From Feb. 19–23, 2017, more than ...
(Date:2/17/2017)... ... February 17, 2017 , ... Access today announced that ... Orlando, Fla., February 19-23. Visitors to the company’s booth (#1778) will be the ... patient signatures solution in healthcare . , Since it first introduced Electronic ...
(Date:2/17/2017)... ... February 17, 2017 , ... Cancer diagnostics workflow ... Tri-Conference February 20 – 22 in San Francisco. As part of the Tri-Conference ... molecular pathology workflow solution, as well as its new precision medicine platform, “Crosswalk ...
(Date:2/16/2017)... New York, New York (PRWEB) , ... February ... ... hard work and determination. After what took over 10 years of research, development ... disruptive technology, NTX Technology™. NTX Technology™ is a patented compound of FDA approved ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... , Feb. 16, 2017  AcelRx Pharmaceuticals, ... pharmaceutical company focused on the development and commercialization ... acute pain, announced that Vincent J. Angotti ... a member of the company,s board of directors, ... over two decades of experience leading executive and ...
(Date:2/16/2017)... -- Prescription pain medications provided by "physicians in the months ... opioid use to take hold," according to a new ... The New England Journal of Medicine (NEJM). ... acute pain than in almost any other medical setting," ... the American College of Emergency Physicians. "The challenge is ...
(Date:2/16/2017)... Research and Markets has announced the addition of the "Global ... Cancer Type, Technology - Forecast to 2025" report to their ... The ... a CAGR of around 28.6% over the next decade to reach ... the prominent trends that the market is witnessing include increasing demand ...
Breaking Medicine Technology: