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Is RTA a new potential option for the treatment of hydatid cysts?
Date:7/24/2009

(9/9) and lung cysts (8/8). A layer of host tissue necrosis outside the cyst, with average extension of 0.64 cm for liver, and 1.57 cm for lung, was also seen. The endocyst remained attached to the pericystium both in hepatic and lung cysts, with small and focal de novo detachment in just 3/9 hepatic cysts. Finally, after treatment, the authors found immediate volume reduction of the cysts of at least 65%.

The research was performed with internal funding at the Mediterranean Institute for Transplantation and Advanced Therapies (ISMETT) in Palermo, Italy thanks to a collaborative effort with the Veterinary Service of the Region of Sicily. ISMETT is a multi-organ transplant center founded in 1999 as a partnership between the Region of Sicily and the University of Pittsburgh Medical Center (UPMC). In this Italian center, located in the heart of the Mediterranean Basin, liver, kidney, heart, lung, pancreas and combined transplants, from both cadaveric and living donors, are performed. General cardiac surgery, abdominal surgery and interventional radiology procedures are also performed. Dr. Lamonaca, an infectious disease specialist, has been working at the institute as a consultant since 2001. Following up patients with hydatid disease of the liver treated with surgery or PAIR and presenting infective complications, the first author conceived this research as an attempt to identify a therapeutic alternative approach to surgery and PAIR, at least as effective as those techniques, but able to overcome their post-procedure complications.

This pilot study was performed on animal organs in order to be able to verify the final effects of this new approach, very unlikely to be verified in treated patients. Since hydatidosis is a zoonosis endemic in Sicily, the authors decided to use organs from slaughtered animals, with minimal economic costs and no ethical implications.

Although the study was performed on explanted animal organs, the authors bel
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Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

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