Navigation Links
Is Duloxetine more or less effective than Fluoxetine in children and teens with MDD?
Date:5/19/2014

New Rochelle, NY, May 19, 2014Two studies of the anti-depressive drug duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), compared its effectiveness and safety to either fluoxetine or placebo in children and adolescents with major depressive disorder (MDD). The results of these first controlled trials of duloxetine in pediatric patients with MDD are published in Journal of Child and Adolescent Psychopharmacology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available free on the Journal of Child and Adolescent Psychopharmacology

.

Graham Emslie, MD and coauthors evaluated the efficacy and safety of a fixed dose of duloxetineeither 60 mg or 30 mg once a dayversus 20 mg daily of fluoxetine or placebo in children ages 7-11 years and adolescents ages 12-17 years. In the article "A Double-Blind Efficacy and Safety Study of Duloxetine Fixed Doses in Children and Adolescents with Major Depressive Disorder" they compare the treatments based on worsening of suicidal ideation, emergence of suicidal behavior, and adverse effects including abnormal findings on an electrocardiogram and laboratory tests.

Sarah Atkinson, MD and colleagues compared a flexible dosing regimen of duloxetine (60-120 mg daily) to fluoxetine (20-40 mg daily) or placebo and reported measures from a depression rating scale and a suicide severity rating scale, as well as treatment-related adverse events, in the article "A Double-Blind Efficacy and Safety Study of Duloxetine Flexible Dosing in Children and Adolescents with Major Depressive Disorder".

Neither study found a significant difference in response between the two drugs and placebo. The authors suggest that this may be due to the complexity of these novel studies and offer observations that may direct the design of future investigations.

"Drs. Emslie and Atkinson and their colleagues took a fascinating approach towards testing the efficacy of a novel SNRI in the pediatric population," said Harold S. Koplewicz, MD, Editor-in-Chief of Journal of Child and Adolescent Psychopharmacology, and President, Child Mind Institute, New York, NY. "Researchers are of course excited by positive results, but in this case the curious lack of response tells us volumes about how to better design complex studiesstudies that may soon give us uncommon insight into our pharmacologic interventions."


'/>"/>
Contact: Kathryn Ruehle
kruehle@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related medicine news :

1. Medication duloxetine helps reduce pain from chemotherapy
2. Widely used drug no more effective than FDA approved medication in treating epileptic seizures
3. New agent may enhance effectiveness of radiotherapy
4. A form of immune therapy might be effective for multiple myeloma
5. Universal neuromuscular training an inexpensive, effective way to reduce
6. Study finds family-based exposure therapy effective treatment for young children with OCD
7. New study says probiotic use for infant colic is not effective in reducing symptoms
8. New human trial shows stem cells are effective for failing hearts
9. Heparin more effective than bivalirudin in patients during emergency heart procedure
10. Researchers: Biomarkers predict effectiveness of radiation treatments for cancer
11. Primary androgen deprivation therapy ineffective for most men with early prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Is Duloxetine more or less effective than Fluoxetine in children and teens with MDD?
(Date:4/22/2017)... ... April 22, 2017 , ... PharmacyChecker.com released its first International ... of 70% when buying medication online from Canadian pharmacies verified in the PharmacyChecker ... other countries. The report (chart below) compares U.S. and foreign prices for 20 ...
(Date:4/21/2017)... ... 21, 2017 , ... Providing broad access to life-saving drugs and rewarding the ... better way to address this problem. , That was the message from Dana Goldman, ... at the University of Southern California, who served as the keynote speaker for Western ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... adolescents and young adults, has kicked off its 4th annual Forum for Innovative ... year’s theme is “Attachment Informed Therapy for Mental Health and Addiction.” , ...
(Date:4/21/2017)... ... April 21, 2017 , ... The adage “Show, don’t tell” applies ... project in the company’s esteemed VISION House demonstration project series. Manifesting the concept of ... of resources they need to live affordably and abundantly without unduly taxing the resources ...
(Date:4/21/2017)... ... 21, 2017 , ... Crossover Symmetry , an evidence ... active lifestyle company that provides Human Performance Training and education to tactical athletes. ... responders, military officers and others in service through the development and conditioning of ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Research and Markets has announced the addition of the ... Market and Increasing Usage of Complex Biologics during the Forecast Period" ... ... 20 Billion in 2015 to around USD 26 Billion by 2020. ... by Rapidly Expanding Injectables Market and Increasing Usage of Complex Biologics ...
(Date:4/20/2017)... , April 20, 2017 ... platform, the first non-viral gene expression technology that enables ... the eye to address a wide range of ophthalmic ... Medicines and Healthcare products Regulatory Agency (MHRA) to advance ... ...
(Date:4/19/2017)... The Mobile X-Ray product segment is the most ... the forecast period Mobile X-Ray segment is the ... X-Ray devices market, which is estimated to be valued at ... CAGR of 7% over the forecast period. Mobile X-Ray segment ... US$ 100 Mn in 2017 over 2016. The segment,s revenue ...
Breaking Medicine Technology: