Navigation Links
Is 4 agents decoction (Si Wu Tang) efficacious in treating primary dysmenorrhea?
Date:8/21/2007

New research by scientists in Taiwan has shown that an 800-year-old formula, Four-Agents Decoction (Si Wu Tang), does not significantly reduce menstrual pain after three cycles of treatment; however, a beneficial effect may be present after a longer treatment. The dosage regimen and treatment length used in this study are not associated with adverse reactions. The results are published in the August 15 issue of the online, open-access journal PLoS ONE.

Four-Agents Decoction is composed of dry roots of four plants native to China: prepared Radix Rehmanniae praeparata (Soe Dee Huang), Radix Paeoniae Alba (Bai Sau), Radix Angelicae Sinensis (Dang Guay), and Rhizoma Ligustici Chuanxiong (Tsuan Chyong). This formula is originally listed in the Prescriptions of Peoples Welfare Pharmacy (in Chinese) as a remedy for nourishing the blood and has been used as a basic formula in traditional Chinese medicine for treating womens illnesses since the Song dynasty (twelfth century). Although many analgesics are available, this formula is worth studying, as non-specified dysmenorrhoea is still one of the most common gynecological complaints in young women worldwide.

The participants in the study were 78 primary dysmenorrheic women in the Taipei, Taiwan, metropolitan area. At the end of treatment, both menstrual overallpain- and peak-pain-intensity did not differ significantly between the Four-Agents-Decoction group and the placebo group. But statistically significant pain-reducing effect appeared in the first follow-up cycle.

We did not obtain clear evidence for our hypothesis that Four-Agents-Decoction had a beneficial effect to treat primary dysmenorrhoea says Dr. Lan Lan Liang Yeh, the studys principal investigator. But the unexpected result of a statistically significant pain-reducing effect in the first post-treatment cycle is intriguing and warrants a rigorous similar trial with a larger sample size, a longer treatment phase, and multiple batched study products in different populations to determine the definitive efficacy of this historically documented formula.


Disclaimer

The following press release refers to an article in PLoS ONE. The release has been provided by the article authors and/or their institutions. Any opinions expressed in this are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.

The protocol underwent reviews by the National Health Research Institutes and the study received funding support from NHRI; the Department of Health, Taiwan; and the National Science and Technology Program for Biotechnology and Pharmaceuticals.

Notes for editors The government of Taiwan established the National Health Research Institutes in 1996. NHRI is a non-profit, autonomous research organization dedicated to the enhancement of medical research and the improvement of health care in Taiwan.

Contact: Pochuan Li

Public Affairs Office, National Health Research Institutes Tel: +886-2-37-246166 ext31500 Email: pochuan@nhri.org.tw

Citation: Yeh LLL, Liu J, Lin K, Liu Y, Chiou J, et al. (2007) A Randomised Placebo-Controlled Trial of a Traditional Chinese Herbal Formula in the Treatment of Primary Dysmenorrhoea. PLoS ONE 2(8): e719. doi:10.1371/journal.pone.0000719

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://www.plosone.org/doi/pone.0000719


'/>"/>
Contact: Pochuan Li
pochuan@nhri.org.tw
Public Library of Science
Source:Eurekalert

Related medicine news :

1. New target for antidiabetic agents identified
2. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
3. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
4. Newer Contrast Agents Safe for Children
5. Less Allergic Reactions to Iodine-containing Contrast Agents in Children
6. Gene Therapy shows promise in treating Hemophilia
7. Treating Depression In Children Could Lead To Poor Bone Development
8. Treating Epilepsy With Surgery
9. Treating Autism More Effectively
10. Stem Cell Therapy Effective For Treating Heart Attacks
11. Treating Leukemia With Natural Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... Qualitative ... seeks to add a deeper understanding of the program, policy or intervention being ... answers different yet important questions. , In a new brief released today, Reading ...
(Date:5/4/2016)... SCOTTSDALE, AZ (PRWEB) , ... May 04, 2016 ... ... 2016 Annual Technology & Business Conference. The conference opened on Tuesday with Frank ... panel discussion on NCPDP’s PDMP Solution provided a deep dive on NCPDP’s model ...
(Date:5/4/2016)... ... May 04, 2016 , ... The RIDER Institute announces ... of DRACO broad-spectrum antiviral therapeutics. DRACOs have proven effective against all 18 viruses ... 2016 at http://igg.me/at/EndTheVirus and runs for 60 days, we are raising ...
(Date:5/4/2016)... ... May 04, 2016 , ... a2z, Inc. is ... and Canadian Association for Enterostomal Therapy (CAET) will be utilizing powerful and innovative ... to attendees and exhibitors for the 2016 WOCN Society & CAET Joint Conference—which ...
(Date:5/4/2016)... ... ... May kicked off with Melanoma Monday , a multi-agency effort to raise ... encouraging her patients, as well as residents all around Dallas, Cleburne, Irving, and Plano, ... in the future. , The dermatology-specific awareness month ends with “Don’t Fry Day,” established ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Research and Markets has ... Myeloma Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... Highlights 2016, provides comprehensive insights into Multiple ... Myeloma market valuations and forecast, Multiple Myeloma ...
(Date:5/3/2016)... PUNE, India , May 4, 2016 /PRNewswire/ ... report spreads across 154 pages, profiling 09 key ... It is a professional and in-depth study on ... providing a basic overview of the industry including ... Insulin Needles market analysis is provided for the ...
(Date:5/3/2016)... Pa. , May 3, 2016 ACME ... Jack Whelan and Delaware County ... (naloxone HCI) Nasal Spray in all ACME ... U.S. Centers for Disease Control and Prevention (CDC), naloxone has saved ... when police officers in Delaware County were ...
Breaking Medicine Technology: