Navigation Links
Is 4 agents decoction (Si Wu Tang) efficacious in treating primary dysmenorrhea?
Date:8/21/2007

New research by scientists in Taiwan has shown that an 800-year-old formula, Four-Agents Decoction (Si Wu Tang), does not significantly reduce menstrual pain after three cycles of treatment; however, a beneficial effect may be present after a longer treatment. The dosage regimen and treatment length used in this study are not associated with adverse reactions. The results are published in the August 15 issue of the online, open-access journal PLoS ONE.

Four-Agents Decoction is composed of dry roots of four plants native to China: prepared Radix Rehmanniae praeparata (Soe Dee Huang), Radix Paeoniae Alba (Bai Sau), Radix Angelicae Sinensis (Dang Guay), and Rhizoma Ligustici Chuanxiong (Tsuan Chyong). This formula is originally listed in the Prescriptions of Peoples Welfare Pharmacy (in Chinese) as a remedy for nourishing the blood and has been used as a basic formula in traditional Chinese medicine for treating womens illnesses since the Song dynasty (twelfth century). Although many analgesics are available, this formula is worth studying, as non-specified dysmenorrhoea is still one of the most common gynecological complaints in young women worldwide.

The participants in the study were 78 primary dysmenorrheic women in the Taipei, Taiwan, metropolitan area. At the end of treatment, both menstrual overallpain- and peak-pain-intensity did not differ significantly between the Four-Agents-Decoction group and the placebo group. But statistically significant pain-reducing effect appeared in the first follow-up cycle.

We did not obtain clear evidence for our hypothesis that Four-Agents-Decoction had a beneficial effect to treat primary dysmenorrhoea says Dr. Lan Lan Liang Yeh, the studys principal investigator. But the unexpected result of a statistically significant pain-reducing effect in the first post-treatment cycle is intriguing and warrants a rigorous similar trial with a larger sample size, a longer treatment phase, and multiple batched study products in different populations to determine the definitive efficacy of this historically documented formula.


Disclaimer

The following press release refers to an article in PLoS ONE. The release has been provided by the article authors and/or their institutions. Any opinions expressed in this are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.

The protocol underwent reviews by the National Health Research Institutes and the study received funding support from NHRI; the Department of Health, Taiwan; and the National Science and Technology Program for Biotechnology and Pharmaceuticals.

Notes for editors The government of Taiwan established the National Health Research Institutes in 1996. NHRI is a non-profit, autonomous research organization dedicated to the enhancement of medical research and the improvement of health care in Taiwan.

Contact: Pochuan Li

Public Affairs Office, National Health Research Institutes Tel: +886-2-37-246166 ext31500 Email: pochuan@nhri.org.tw

Citation: Yeh LLL, Liu J, Lin K, Liu Y, Chiou J, et al. (2007) A Randomised Placebo-Controlled Trial of a Traditional Chinese Herbal Formula in the Treatment of Primary Dysmenorrhoea. PLoS ONE 2(8): e719. doi:10.1371/journal.pone.0000719

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://www.plosone.org/doi/pone.0000719


'/>"/>
Contact: Pochuan Li
pochuan@nhri.org.tw
Public Library of Science
Source:Eurekalert

Related medicine news :

1. New target for antidiabetic agents identified
2. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
3. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
4. Newer Contrast Agents Safe for Children
5. Less Allergic Reactions to Iodine-containing Contrast Agents in Children
6. Gene Therapy shows promise in treating Hemophilia
7. Treating Depression In Children Could Lead To Poor Bone Development
8. Treating Epilepsy With Surgery
9. Treating Autism More Effectively
10. Stem Cell Therapy Effective For Treating Heart Attacks
11. Treating Leukemia With Natural Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ANDOVER, Mass. and SAN CLEMENTE, Calif. ... California -based mobile pulmonary function testing company, is now ... portable PFT devices developed by ndd Medical Technologies , Inc. ... PFT testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ... CA , can get any needed testing done in the ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
Breaking Medicine Technology: