Navigation Links
Irregular arm swing may point to Parkinson's disease
Date:12/10/2009

Irregular arm swings while walking could be an early sign of Parkinson's disease, according to neurologists who believe early detection may help physicians apply treatments to slow further brain cell damage until strategies to slow disease progression are available.

Parkinson's disease is an age-related disorder involving loss of certain types of brain cells and marked by impaired movement and slow speech.

"The disease is currently diagnosed by tremors at rest and stiffness in the body and limbs," said Xuemei Huang, associate professor of neurology, Penn State Hershey College of Medicine. "But by the time we diagnose the disease, about 50 to 80 percent of the critical cells called dopamine neurons are already dead."

Huang and her colleagues are studying gait, or the manner in which people walk, to understand the physical signs that might be a very early marker for the onset of Parkinson's. They have confirmed Huang's clinical impression that in people with Parkinson's, the arm swing is asymmetrical. In other words, one arm swings much less than the other as a person walks.

"We know that Parkinson's patients lose their arm swing even very early in the disease but nobody had looked using a scientifically measured approach to see if the loss was asymmetrical or when this asymmetry first showed up," said Huang. Her team's findings appear in the current issue of Gait and Posture. "Our hypothesis is that because Parkinson's is an asymmetrical disease, the arm swing on one arm will be lost first compared to the other."

The researchers compared the arm swing of 12 people diagnosed three years earlier with Parkinson's, to eight people in a control group. The Parkinson's patients were asked to stop all medication the night before to avoid influencing the test results.

The team used special equipment to measure movement accurately, including many reflective markers on the study participants and eight digital cameras that captured the exact position of each segment of the body during a walk.

"Images from the cameras were sent to a computer where special software analyzed the data" explained Huang. "When a person walks, the computer was able to calculate the degree of swing of each arm with millimeter accuracy."

Analysis of the magnitude of arm swing, asymmetry and walking speed revealed that the arm swing of people with Parkinson's has remarkably greater asymmetry than people in the control group -- one arm swung significantly less than the other in the Parkinson's patients.

When the participants walked at a faster speed, the arm swing increased but the corresponding asymmetry between them remained the same.

"We believe this is the first demonstration that asymmetrical arm swings may be a very early sign of the disease," said Huang.

While slightly irregular arm swing occurs in people without Parkinson's, the asymmetry is significantly larger in those suffering from the disease.

"Our data suggests that this could be a very useful tool for the early detection of Parkinson's," noted Huang. "There are wide scale efforts to find drugs that slow cell death. When they are found, they could be used in conjunction with this technique to arrest or perhaps cure the disease because they could be given before great damage has occurred."


'/>"/>

Contact: Amitabh Avasthi
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related medicine news :

1. Simple blood test could reduce repeat breast MRI scans in premenopausal women with irregular periods
2. Sleep Apnea Episodes May Trigger Irregular Heartbeat
3. Irregular Heartbeat Risk Higher in Women With Type 2 Diabetes
4. Endometrial Ablation Offers Relief for Abnormally Heavy or Irregular Menstrual Bleeding
5. Glenmark Brings to the Notice of the Authorities Irregularities of the Clinical Investigator at its Jamnagar Site in Gujarat
6. Irregular Heartbeat Tied to Alzheimers Disease
7. Irregular Heartbeat During Angioplasty Could Raise Death Risk
8. Blood Pressure Drug May Not Ease Irregular Heartbeat
9. Most Patients With Irregular Heartbeat Take Inadequate Blood Thinner Dose
10. Delayed Sleep Pattern Tied to Irregular Menstrual Cycles
11. Statins May Help Older Women Control Irregular Heartbeat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, ... (iPS) cells and other difficult to transfect cells, announces its launch of the ... G9™ Gene Editing System is a complete system for culturing and transfecting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
Breaking Medicine Technology: