Navigation Links
Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
Date:8/2/2010

Tiny particles of iron oxide could become tools for simultaneous tumor imaging and treatment, because of their magnetic properties and toxic effects against brain cancer cells. In mice, researchers from Emory University School of Medicine have demonstrated how these particles can deliver antibodies to implanted brain tumors, while enhancing tumor visibility via magnetic resonance imaging (MRI).

The results are published online by the journal Cancer Research.

The lead author is Costas Hadjipanayis, assistant professor of neurosurgery at Emory University School of Medicine, director of Emory's Brain Tumor Nanotechnology Laboratory, and chief of neurosurgery service at Emory University Hospital Midtown.

Glioblastoma multiforme (GBM), the most common and most aggressive primary brain tumor, often comes back because cancer cells infiltrate into the surrounding brain tissue and survive initial treatment. Hadjipanayis' team designed tiny iron oxide particles (10 nanometers across), coated with a polymer and bioconjugated or linked to antibodies directed against a molecule that appears on the surface of glioblastoma cells.

This molecule, a shortened and continuously active form of the epidermal growth factor receptor (EGFRvIII), drives glioblastoma cell growth and accounts for radiation and chemotherapy resistance. EGFRvIII appears in about a third of glioblastomas and is only present on tumor cells and not the normal surrounding cells in the brain.

The team showed that the particles bind to and kill human glioblastoma cells, yet do not cause any toxicity to normal human astrocytes, which comprise the majority of cells in the brain. They used a technique called convection-enhanced delivery (CED) continuous infusion of fluid under positive pressure to introduce the iron oxide particles into mice that had human glioblastoma cells implanted intracranially.

The antibody-linked particles lengthened survival of the tumor-implanted mice: their median survival was 19 days compared to 16 days for bare particles and 11 days for no particles. The particles also made the tumor visible via MRI, darkening the area of the brain where the tumor is (see accompanying image). Hui Mao, PhD associate professor of radiology, and his team of researchers, contributed MRI experiments showing the sensitive imaging qualities of the iron-oxide nanoparticles in vitro and in the mouse brain.

To heighten anti-cancer effects, the Brain Tumor Nanotechnology Laboratory is investigating the use of safe alternating magnetic fields for the generation of local hyperthermia (heating) against malignant brain tumors by magnetic nanoparticles.

Hadjipanayis and his team plan to translate the use of bioconjugated iron-oxide nanoparticles for use in canine brain tumor models at the University of Georgia College of Veterinary Medicine and into a human clinical trial for patients suffering from brain cancer.


'/>"/>

Contact: Janet Christenbury
jmchris@emory.edu
404-727-8599
Emory University
Source:Eurekalert  

Related medicine news :

1. Nitric Oxide Doesnt Seem to Help Preemies Lungs: Report
2. As Summer Heats Up, Glacier Creme Debuts the Ultimate in Natural Sunscreen: 'Naked Protection' with Zinc Oxide
3. DTWI's Travel Carbon Monoxide Detector Prevents Carbon Monoxide Poisoning Whilst Holidaying Abroad, or in the UK
4. Study: Carbon Monoxide Exposure Can be Reduced During Routine Anesthesia in Kids
5. Researchers show that nitric oxide-donating naproxen can boost colorectal cancer prevention
6. Exposure to nitrogen dioxide lowers in vitro fertilization success
7. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
8. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
9. Curcumin nanoparticles open up resistant cancers
10. Novel nanoparticles prevent radiation damage
11. Attacking cancer cells with hydrogel nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
(Date:1/18/2017)... ... January 18, 2017 , ... Delaware farmer Rick Dickerson attended the 2017 ... of Laurel, farms about a thousand acres of soybeans, corn and wheat, and raises ... pumpkins and other vegetables for the fresh market. He also operates a roadside stand ...
(Date:1/18/2017)... and SHANGHAI, China – , ... ... Global public health organization NSF International has certified the first ... NSF/ANSI 53: Drinking Water Treatment Units – Health Effects, an ... verifies that MicroCeramics’ NanoNose Pitcher Filter System filters the water ...
(Date:1/18/2017)... ... January 18, 2017 , ... PrideStaff, a national, franchised ... Development, Paula Turner Pizarro, was recently featured on Fox Business Network's Worldwide Business ... top business leaders from across the globe, provides viewers an opportunity to find ...
(Date:1/18/2017)... ... January 18, 2017 , ... Dr. Farhan Qureshi is an esteemed dentist who ... modern dental practice has two convenient office locations in Alexandria and Arlington, Virginia. Recently, ... for the Alexandria area. This award confirms the fact that Dr. Qureshi’s patients ...
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, ... Brake Technology (ABT), an innovative braking system that allows skaters of all levels ... one of the biggest concerns of beginner and intermediate skaters – learning how ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... In China , we say ... Upgrade of China,s Healthy Strategy originates. ... for Economic and Social Development of the People,s ... the state council of the People,s Republic of ... industry development plan, identifying medical devices as one of the ...
(Date:1/18/2017)... Ximbio, a non-profit online one-stop-shop for the global ... first North American headquarters in Kendall Square, Cambridge, ... ... launch in October 2014 as a business unit of UK- ... the foundation Cancer Research UK. Ximbio.com allows scientists ...
(Date:1/18/2017)... and Drug Administration CSL CureVac Daiichi ... Drug Administration FORT Fresenius Pharmaceuticals Gamma ... GlaxoWellcome Global Influenza Programme Grippol ... Targeting Systems Indian Association of Paediatrics Janssen Pharmaceuticals ... Krka Pharmaceuticals Medicago Medicare ...
Breaking Medicine Technology: