Navigation Links
Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
Date:8/2/2010

Tiny particles of iron oxide could become tools for simultaneous tumor imaging and treatment, because of their magnetic properties and toxic effects against brain cancer cells. In mice, researchers from Emory University School of Medicine have demonstrated how these particles can deliver antibodies to implanted brain tumors, while enhancing tumor visibility via magnetic resonance imaging (MRI).

The results are published online by the journal Cancer Research.

The lead author is Costas Hadjipanayis, assistant professor of neurosurgery at Emory University School of Medicine, director of Emory's Brain Tumor Nanotechnology Laboratory, and chief of neurosurgery service at Emory University Hospital Midtown.

Glioblastoma multiforme (GBM), the most common and most aggressive primary brain tumor, often comes back because cancer cells infiltrate into the surrounding brain tissue and survive initial treatment. Hadjipanayis' team designed tiny iron oxide particles (10 nanometers across), coated with a polymer and bioconjugated or linked to antibodies directed against a molecule that appears on the surface of glioblastoma cells.

This molecule, a shortened and continuously active form of the epidermal growth factor receptor (EGFRvIII), drives glioblastoma cell growth and accounts for radiation and chemotherapy resistance. EGFRvIII appears in about a third of glioblastomas and is only present on tumor cells and not the normal surrounding cells in the brain.

The team showed that the particles bind to and kill human glioblastoma cells, yet do not cause any toxicity to normal human astrocytes, which comprise the majority of cells in the brain. They used a technique called convection-enhanced delivery (CED) continuous infusion of fluid under positive pressure to introduce the iron oxide particles into mice that had human glioblastoma cells implanted intracranially.

The antibody-linked particles lengthened survival of the tumor-implanted mice: their median survival was 19 days compared to 16 days for bare particles and 11 days for no particles. The particles also made the tumor visible via MRI, darkening the area of the brain where the tumor is (see accompanying image). Hui Mao, PhD associate professor of radiology, and his team of researchers, contributed MRI experiments showing the sensitive imaging qualities of the iron-oxide nanoparticles in vitro and in the mouse brain.

To heighten anti-cancer effects, the Brain Tumor Nanotechnology Laboratory is investigating the use of safe alternating magnetic fields for the generation of local hyperthermia (heating) against malignant brain tumors by magnetic nanoparticles.

Hadjipanayis and his team plan to translate the use of bioconjugated iron-oxide nanoparticles for use in canine brain tumor models at the University of Georgia College of Veterinary Medicine and into a human clinical trial for patients suffering from brain cancer.


'/>"/>

Contact: Janet Christenbury
jmchris@emory.edu
404-727-8599
Emory University
Source:Eurekalert  

Related medicine news :

1. Nitric Oxide Doesnt Seem to Help Preemies Lungs: Report
2. As Summer Heats Up, Glacier Creme Debuts the Ultimate in Natural Sunscreen: 'Naked Protection' with Zinc Oxide
3. DTWI's Travel Carbon Monoxide Detector Prevents Carbon Monoxide Poisoning Whilst Holidaying Abroad, or in the UK
4. Study: Carbon Monoxide Exposure Can be Reduced During Routine Anesthesia in Kids
5. Researchers show that nitric oxide-donating naproxen can boost colorectal cancer prevention
6. Exposure to nitrogen dioxide lowers in vitro fertilization success
7. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
8. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
9. Curcumin nanoparticles open up resistant cancers
10. Novel nanoparticles prevent radiation damage
11. Attacking cancer cells with hydrogel nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
(Date:5/24/2016)... ... May 24, 2016 , ... ... Cifolelli has joined the company as Vice President of Sales. Cifolelli’s primary ... and international sales in the rapidly expanding field of organizational social engineering. ...
(Date:5/24/2016)... ... May 24, 2016 , ... i2i, ... identity and website at its “Transforming Outcomes” User Conference in Las Vegas on ... i2i’s ongoing success to set the market standard for meaningful population health management. ...
(Date:5/24/2016)... ... May 24, 2016 , ... Educational opportunities, ... housing, with more advantaged communities providing richer opportunities. Recognizing the key role of ... school improvement policies; (b) school choice policies; (c) school desegregation policies; (d) wealth-focused ...
(Date:5/24/2016)... Georgia (PRWEB) , ... May 24, 2016 , ... Mental ... 1969 by the Church of Scientology and renowned professor of psychiatry Thomas Szasz, is ... of its “Psychiatry: An Industry of Death” exhibit in Atlanta, Georgia. The opening of ...
(Date:5/24/2016)... NY (PRWEB) , ... May 24, 2016 , ... ... treatment for physical disease or injury that focuses on repairing the musculoskeletal and ... , With an emphasis on functional restoration, NYDNRehab began providing treatments for physical ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LAWRENCE, Mass. , May 24, 2016  NxStage ... medical technology company focused on advancing renal care, today ... Officer, plans to participate in the following schedule of ... will be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, ...
(Date:5/24/2016)... May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior vice president ... today. In his new role, Marziani will lead the company,s business development and sales ... improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... , May 24, 2016 ... doble terapia del mundo, introduce catéteres para la ... OrbusNeich, una compañía global especializada en el ... ha expandido su cartera incluyendo productos para tratar ... y Scoreflex™ PTA son los dispositivos de primera ...
Breaking Medicine Technology: