Navigation Links
Iron overload: An important co-factor in the development of liver disease in alcoholics
Date:2/17/2009

Alcohol and iron are believed to have a synergistic effect in the development of liver injury. Furthermore, alcohol enhances iron absorption. Primary hemochromatosis is a genetic disorder, mostly resulting from mutations in the HFE gene, with a disturbance in the iron metabolism which leads to iron accumulation that may eventually result in liver disease. However, data regarding an association between iron metabolism, HFE mutations and alcoholic liver disease are inconclusive at present.

A research article to be published on January 7, 2009 in the World Journal of Gastroenterology addresses this question. A research team led by Professor Helena Cortez-Pinto, from Hospital Santa Maria in Lisbon, studied a group of heavy drinkers with and without liver disease. A high prevalence of iron overload was found in alcoholics, which appeared to be related to the development of liver disease [odds ration for having liver disease in alcoholics with transferrin saturation greater than 45% was 2.2 (95% CI 1.37-3.54)]. Regarding HFE mutations, only H63D was found to be associated with alcoholic liver disease [odds ratio 1.57 (95% CI 1.02-2.40)]. Alcoholics who were heterozygotes for H63D mutation and had evidence of iron overload, showed an even greater risk of developing liver disease [odds ratio 2.17 (95% CI 1.42-3.32)].

Based on these findings, it appears that iron overload is an important co-factor in the development of liver disease in alcoholics. Even heterozygotes for H63D mutation, who classically do not develop liver disease, had an increased susceptibility to liver disease, in the presence of excessive alcohol consumption.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
2. New class of RNA molecules may be important in human cancer
3. UVA researchers find important clue to immune infertility
4. Catholic Charities USA Calls on Congress and the President to Protect the Health of Children; Urges President Not to Veto Vitally Important Bill
5. In Honor of Hispanic Heritage Month and Spanish Speakers Worldwide International Hyperhidrosis Society Publishes Important New Patient Booklet in Spanish
6. Daytime, Nighttime Blood Pressure Both Important
7. Schwarzenegger Signs Bill to Remove Written Informed Consent for HIV Testing; "Most Important Change in Public HIV/AIDS Policy in Years," Says AHF
8. Video: Holiday Safety Is Important
9. Quality of life: most important predictor of survival for advanced NSCLC patients
10. Research highlights important indicators of early-stage ovarian cancer
11. The most important candidate genes for pancreatic stone formation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... 05, 2016 , ... In order to increase comfort, convenience ... a Seattle-based steam bath and sauna manufacturer recently launched amerecConnect™ , a ... the app, developed for both smartphones and personal computers perfectly emulates that of ...
(Date:5/5/2016)... ... May 05, 2016 , ... In honor of National Nurses Week 2016, ... over the United States to thank a nurse who's made a difference in their ... to the American Red Cross of San Diego/Imperial Counties (up to $10,000) every time ...
(Date:5/5/2016)... CA (PRWEB) , ... May 05, 2016 , ... ... may not seem like an intuitive activity to alleviate the pain that’s a ... effective in improving pain and function in people with arthritis. , “Physical ...
(Date:5/5/2016)... , ... May 05, 2016 , ... Chronic stress can ... constant presence, it can weaken the immune system and increase inflammation, both of which ... director of the adult congenital heart disease program at Harvard-affiliated Massachusetts General Hospital. Chronic ...
(Date:5/5/2016)... Rochester, NY (PRWEB) , ... May 05, 2016 ... ... app is now available for iOS and Android devices. VisualDx is the ... expanded to include diagnostic support across general medicine. The system speeds diagnosis, ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 ... addition of the  "Global Acute Myeloid Leukemia ...  report to their offering.       ... Acute Myeloid Leukemia Market and Competitive Landscape ... Myeloid Leukemia pipeline products, Acute Myeloid Leukemia ...
(Date:5/3/2016)... , May 4, 2016 Research ... "Global Cancer Stem Cell Therapy Market Outlook 2020" ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,Recombinant technology has improved significantly ... expected to be developed in coming years. Many cancer ... Cancer stem cell therapies are also expected to be ...
(Date:5/3/2016)...  While you may be familiar with watching a film or TV show in high definition, ... 8MP in the Medical Industry.  Ampronix  is a renowned authorized reseller of the medical industry,s ... - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: