Navigation Links
Iron overload: An important co-factor in the development of liver disease in alcoholics
Date:2/17/2009

Alcohol and iron are believed to have a synergistic effect in the development of liver injury. Furthermore, alcohol enhances iron absorption. Primary hemochromatosis is a genetic disorder, mostly resulting from mutations in the HFE gene, with a disturbance in the iron metabolism which leads to iron accumulation that may eventually result in liver disease. However, data regarding an association between iron metabolism, HFE mutations and alcoholic liver disease are inconclusive at present.

A research article to be published on January 7, 2009 in the World Journal of Gastroenterology addresses this question. A research team led by Professor Helena Cortez-Pinto, from Hospital Santa Maria in Lisbon, studied a group of heavy drinkers with and without liver disease. A high prevalence of iron overload was found in alcoholics, which appeared to be related to the development of liver disease [odds ration for having liver disease in alcoholics with transferrin saturation greater than 45% was 2.2 (95% CI 1.37-3.54)]. Regarding HFE mutations, only H63D was found to be associated with alcoholic liver disease [odds ratio 1.57 (95% CI 1.02-2.40)]. Alcoholics who were heterozygotes for H63D mutation and had evidence of iron overload, showed an even greater risk of developing liver disease [odds ratio 2.17 (95% CI 1.42-3.32)].

Based on these findings, it appears that iron overload is an important co-factor in the development of liver disease in alcoholics. Even heterozygotes for H63D mutation, who classically do not develop liver disease, had an increased susceptibility to liver disease, in the presence of excessive alcohol consumption.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
2. New class of RNA molecules may be important in human cancer
3. UVA researchers find important clue to immune infertility
4. Catholic Charities USA Calls on Congress and the President to Protect the Health of Children; Urges President Not to Veto Vitally Important Bill
5. In Honor of Hispanic Heritage Month and Spanish Speakers Worldwide International Hyperhidrosis Society Publishes Important New Patient Booklet in Spanish
6. Daytime, Nighttime Blood Pressure Both Important
7. Schwarzenegger Signs Bill to Remove Written Informed Consent for HIV Testing; "Most Important Change in Public HIV/AIDS Policy in Years," Says AHF
8. Video: Holiday Safety Is Important
9. Quality of life: most important predictor of survival for advanced NSCLC patients
10. Research highlights important indicators of early-stage ovarian cancer
11. The most important candidate genes for pancreatic stone formation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & Wellness ... Moonlight to raise money for the American Heart Association Heart Walk. Teams of up ... work together to keep their treadmills moving for 5 hours. Treadmills will start at ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent ... as the number one company for hearing aids, ranking it ... fifteen other brands. ... Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, ...
Breaking Medicine Technology: