Navigation Links
Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
Date:5/16/2008

HOUSTON - Gefitinib, the once-promising drug formerly approved as a second line treatment for lung cancer, also known as Iressa, enhanced the effectiveness of hormonal therapy for the treatment of specific types of metastatic breast cancer, according to a Phase II clinical trial led by researchers at The University of Texas M. D. Anderson Cancer Center.

These findings are surprising and represent the first positive study for Iressa in breast cancer, as well as for the entire class of drugs known as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, said Massimo Cristofanilli, M.D., the study's principal investigator.

Cristofanilli will present the findings at the American Society for Clinical Oncology's (ASCO) upcoming annual meeting as an oral presentation.

"We initiated this study in 2003 with hopes of reducing the resistance to hormonal therapy," said Cristofanilli. "There was a lot of preclinical work indicating that, in fact, resistance to hormonal therapy is strongly associated with an activated EGFR pathway. Also, EGFR over-expression has been associated with endocrine resistance. If there's a double blockage of the EGFR and the estrogen receptor, you may achieve better control of the disease."

The Phase II study enrolled 93 women from 30 centers across the United States and Latin America, with M. D. Anderson enrolling 20 patients. All of the women were newly diagnosed with metastatic breast cancer and were hormone receptor positive and estrogen receptor HER-2 negative. Patients were randomized to receive the aromatase inhibitor Arimidex (1 milligram) and Iressa (250 milligram) daily or Arimidex and placebo. The primary endpoint was progression-free survival.

When the study was unblinded, the researchers were surprised by the distinct findings: in the women who received Arimidex and Iressa, progression-free survival was 14.5 months, compared to 8.2 months in the women who did not rece
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study shows that administering calcium and magnesium effectively reduces neurological sensitivity
2. Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial
3. Having Less Power Impairs the Mind and Ability to Get Ahead, Study Shows
4. Kids Growing Up on Grown Up Drugs: New Research Shows Treatments for Adult Ailments Rapidly Rising in Children
5. Avalere Report Shows Unapproved Prescription Drugs Dropped from CMS Formulary Reference File
6. New Survey Shows Americans Value Oral Health But Knowledge Gap Remains
7. Research shows HPV testing offers women protection for twice as long as smear testing
8. Study shows that prostate cancer increases the risk of bone fracture
9. TAXUS(R) Express(R) Stent Shows Similarly Low Re-Intervention Rates in Patients with Diabetes Compared to Non-Diabetics in ARRIVE Registry Program
10. Mayo Clinic study shows acupuncture and myofascial trigger therapy treat same pain areas
11. Expanded food and nutrition program shows $10 benefit for each $1 spent
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
(Date:11/23/2014)... 2014 Nearly 260 testosterone lawsuits ... deep vein thrombosis and other serious cardiovascular events ... litigation (MDL) underway in the Northern District of ... documents updated on November 17th by the U.S. ... filing of 259 lawsuits against the makers of ...
(Date:11/23/2014)... 23, 2014 (HealthDay News) -- The holidays can be ... sensory overload can trigger major meltdowns, an expert says. ... best of circumstances, but when you have children with ... an occupational therapy professor at University of the Sciences ... "It,s best to let your hosts or visitors know ...
(Date:11/23/2014)... November 23, 2014 This evaluation ... as its significance, programs and manufacturing technological innovation. ... suppliers major market gamers in information. In this ... specifications, prospective, manufacturing value, and 2009-2014 market shares ... evaluation symbolizes the globally and Chinese suppliers finish ...
(Date:11/23/2014)... SWAccessControl.com's high quality access control power suppliers are ... announced its new collection of power suppliers. Additionally, it ... power suppliers. All the new models come with big ... until Dec. 20, 2014. , SWAccessControl.com has thousands of ... it for a long time. It is very wise ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated ... of beach wedding dresses. “If you are looking for ... as soon as possible. Here you can enjoy 70% ... says. , Holding a big marriage ceremony is the ... beautiful beach wedding dress is uppermost priority. Ophelia, one ...
Breaking Medicine News(10 mins):Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 3Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 2Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 3Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 4Health News:Cheap Access Control Power Supplies Online Now at SWAccessControl.com, Special Offer Until Dec. 20, 2014 2Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2
... ... Improvement, FT. LAUDERDALE, ... operations through general cost containment,and revenue enhancement initiatives, key service line ... have,issued Broward Health,s bond ratings. Moody,s Investor Services reaffirmed its ...
... with high blood pressure are less likely than other ... about lifestyle modifications that can help lower their blood ... addition, hypertension (high blood pressure) patients who are not ... or obese are less likely to receive lifestyle modification ...
... Millar Instruments, Inc.,developer and manufacturer of Mikro-Tip(R) ... the launch of its MPVS,Ultra(TM) P-V system for ... MPVS Ultra simultaneously and continuously measures high-fidelity,left ventricular ... of,animals ranging in size from transgenic mice to ...
... Available Online, PRINCETON, N.J., Nov. 2 Nelson Shanks has,depicted ... President Ronald Reagan, Lady Margaret Thatcher,Pope John Paul II, and Luciano ... Jersey is honored to partner with one of the,world,s preeminent portraitists ... An Evening with ...
... Christopher Warren to Cover Medical Devices, ARLINGTON, Va., ... ) (FBR Capital Markets) today announced that,Christopher Warren has ... Senior Research Analyst within its healthcare group and will,focus ... ten years of experience in equity research, and we,value ...
... to be Presented at AASLD Meeting, TAMPA, ... company, today announced results of a,randomized phase II ... chronic hepatitis C genotype 4 receiving nitazoxanide plus,the ... (SVR), or,undetectable level of virus, 12 weeks following ...
Cached Medicine News:Health News:Broward Health Rating Upgraded 2Health News:Broward Health Rating Upgraded 3Health News:Elderly with high blood pressure less likely to get lifestyle modification advice from doctors 2Health News:Millar Instruments Launches Complete Pressure-Volume System for Large and Small Animal Models 2Health News:Distinctive Art Auction Supports American Red Cross of Central New Jersey 2Health News:FBR Capital Markets Hires Senior Healthcare Analyst 2Health News:Phase II Study Shows that Nitazoxanide Significantly Improves Response to Standard of Care in Patients with Chronic Hepatitis C 2Health News:Phase II Study Shows that Nitazoxanide Significantly Improves Response to Standard of Care in Patients with Chronic Hepatitis C 3Health News:Phase II Study Shows that Nitazoxanide Significantly Improves Response to Standard of Care in Patients with Chronic Hepatitis C 4
(Date:11/22/2014)... Statistics released from a number of organizations ... during the holidays, beginning with Thanksgiving eve, which is ... The data, highlighted in an Infographic ... of their annual Sober Days for the Holidays ... drinking and increased rates of DUI injuries and deaths ...
(Date:11/22/2014)... 2014 Many power shifts are occurring ... of patients in the biopharmaceutical market is impacting ... than ever, understanding how to effectively acquire, convert, ... essential. According to recent research ... spent about two-thirds of their patient-focused dollars on ...
(Date:11/21/2014)... DIEGO , Nov. 21, 2014  Tandem ... TNDM ), a medical device company and manufacturer ... announced a partnership with Tidepool, a non-profit dedicated ... open source software platform that increases diabetes data ... Tidepool Platform, which is currently under development, to ...
Breaking Medicine Technology:Alarming Stats Show Holiday Drinking an Issue for Many 2New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3
... Cantel Medical Corp. (NYSE: CMN ) will release the ... Tuesday, June 8 before the market opens, and hold a conference call ... call will be Charles M. Diker , Chairman; Andrew A. Krakauer ... Craig A. Sheldon , Senior Vice President, CFO and Treasurer; and Roy ...
... Fla. , June 1 In a ... records management, MedeFile International, Inc. (OTC Bulletin Board: MDFI.OB), ... announced the signing of an unprecedented agreement with Dr. ... and Registered Nurse in the practice will be incorporating ...
Cached Medicine Technology:Cantel Medical Corp. to Hold Conference Call to Discuss Results for Its Third Quarter Ended April 30, 2010 2In First of Its Kind Setup, MedeFile Interfacing Directly with Physician's Office 2In First of Its Kind Setup, MedeFile Interfacing Directly with Physician's Office 3In First of Its Kind Setup, MedeFile Interfacing Directly with Physician's Office 4
... Vitoss engineered to ... porosity and structure. -TCP ... well in spinal arthrodesis ... defects due to trauma ...
... provides anterior column support for single or ... to L5. The system consists of one ... that are stacked to a desired height, ... fiber reinforced polymer material emulates the biomechanical ...
... Isotis obtained the CE mark for its synthetic ... all the hallmarks of a smart material, i.e. ... motion a cascade of events in the musculo-skeletal ... accelerated skeletal repair and improved fusion, and reduces ...
... Osteon Bone Graft Substitutes a natural alternative ... cadaver bone, but such grafts may introduce ... transmission. Interpore Cross has developed the Pro ... address these needs, offering surgeons a broad ...
Medicine Products: