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Ipilimumab in advanced melanoma: added benefit for non-pretreated patients not proven
Date:6/12/2014

as still 20 percentage points higher on the ipilimumab side of the indirect comparison than on the dacarbazine side. Originally, the difference was almost 40 percentage points.

What is more important, however, is the fact that the documents subsequently submitted did not address the uncertainty resulting from the methods of the unadjusted indirect comparison. Overall, an added benefit of ipilimumab in non-pretreated patients with advanced melanoma versus dacarbazine or vemurafenib is still not proven.

G-BA decides on the extent of added benefit

The dossier assessment is part of the overall procedure for early benefit assessments supervised by the G-BA. After publication of the manufacturer's dossier and the IQWiG dossier assessment, the G-BA conducted commenting procedures, in which the manufacturer submitted additional information. The G-BA subsequently commissioned IQWiG to assess the data subsequently submitted.

If, in the course of the discussions on a commission of the G-BA, a need for further revision arises, IQWiG presents its report in the form of an addendum. The Institute sent the two addenda on ipilimumab to the commissioning agency on 26 March and on 16 May 2014.

The G-BA then decides on the extent of the added benefit in each case, thus completing the early benefit assessment.


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Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

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