Navigation Links
Iowa State chemists track how drug changes, blocks flu virus
Date:2/1/2008

AMES, Iowa An anti-virus drug attacks influenza A by changing the motion and structure of a proton channel necessary for the virus to infect healthy cells, according to a recently published research paper by two Iowa State University chemists.

Mei Hong, Iowa States John D. Corbett Professor in Chemistry, and Sarah Cady, a graduate student in chemistry, are studying the effects of the antiviral drug amantadine on influenza A. Thats the type of flu bug that most commonly makes people sick and the one that has caused the most serious flu epidemics.

Their findings appear in the Feb. 5 edition of the Proceedings of the National Academy of Sciences.

Hong said the findings are particularly important because mutations of the type A virus are resistant to amantadine treatment.

In the last few years, amantadine resistance has skyrocketed among influenza A viruses in Asia and North America, making it imperative to develop alternative antiviral drugs, Hong and Cady wrote in their paper.

To develop those drugs, Hong said researchers first need to understand exactly how amantadine stops the flu virus.

First, some background about how a flu virus infects a healthy cell: A virus begins the process by attaching itself to a healthy cell. The healthy cell surrounds the flu virus and takes it inside the cell through a process called endocytosis. Once in the cell, the virus uses a protein called M2 to open a channel to the healthy cell. Protons from the healthy cell flow through the channel into the virus and raise its acidity. That triggers the release of the virus genetic material into the healthy cell. The virus hijacks the healthy cells resources and uses them to reproduce and spread the virus.

If the M2 proton channel is blocked, the process doesnt work and a virus cant infect a cell and spread.

Hong and Cady studied the proton channel with the help of solid-state nuclear magnetic resonance spe
'/>"/>

Contact: Mei Hong
mhong@iastate.edu
515-294-3521
Iowa State University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Sharing Miracles Television Program to Feature North Carolina State Womens Basketball Coach Kay Yow
2. Obesity Action Coalition Calls on the State of Mississippi House of Representatives to Withdraw House Bill 282 Discriminating Against Those Affected by Obesity
3. Experimental Vaccine Halts Prostate Cancer in Mice
4. MedWaves, Inc. Announces Receipt of United States Food and Drug Administration 510k Clearance to Market Its Patented Microwave Coagulation/Ablation System
5. CAHI Releases Updated Health Insurance Mandates in the States
6. Los Angeles Daily Journal Names Richardson & Patel Verdict Top in the State of California for 2007
7. SAFC Pharma Expands Its Pharmorphix Solid State Chemistry Services
8. Researchers investigate links between prostate, cadmium, zinc
9. Pennsylvania Education Secretary Lauds Action on Measure to Create Statewide School Health Benefits System
10. Urinary dysfunction troubles men who undergo prostate removal
11. Capital BlueCross CEO Says Meaningful Statewide Competition Must Be Key Criteria in Pennsylvanias Review of Proposed Highmark-IBC Merger
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iowa State chemists track how drug changes, blocks flu virus
(Date:8/21/2014)... TX (PRWEB) August 21, 2014 When children ... of germs that can cause them to become sick and ... practice healthy habits to help them fight these germs to ... and children to do just that with its XFactor program. ... by providing free chewable multi-vitamins. Children ages 4 and up ...
(Date:8/21/2014)... 2014 CarePoint Health is proud ... Patel, MD, and Sujoy Menon, MD, have joined ... and Dr. Menon to the community. CarePoint Health’s ... imaging services to patients in Hudson County through ... Hospital and Hoboken University Medical Center. Our board ...
(Date:8/21/2014)... have developed a genetically engineered line of mice that ... on epilepsy, Alzheimer,s and other diseases. , The ... of fluorescence in response to different calcium levels. This ... and microglia, to be studied in a new way. ... how the brain works," said Petr Tvrdik, Ph.D., ...
(Date:8/21/2014)... Individuals with schizophrenia often have trouble engaging in daily ... study from San Francisco State University suggests the reason ... effort required to complete tasks. , The research, detailed ... Journal of Abnormal Psychology , can assist health professionals ... help those patients function normally by breaking up larger, ...
(Date:8/21/2014)... 2014 According to a new market ... System Market- Global Industry Analysis, Size, Share, Growth, Trends ... market was valued at USD 1,531.2 million in 2013 ... 22.8% from 2013 to 2019, to reach an estimated ... the microfluidic device market is witnessing significant growth due ...
Breaking Medicine News(10 mins):Health News:MedX Pharmacy Helps with Back to School Preparation 2Health News:Two Top Radiologists Join CarePoint Health 2Health News:Mouse model for epilepsy, Alzheimer's gives window into the working brain 2Health News:Difficulty assessing effort drives motivation deficits in schizophrenia, study finds 2Health News:Global Microfluidic Device System Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Global Microfluidic Device System Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3
... 27 Aflac Incorporated,(NYSE: AFL ) announced today ... & Woods 2008 Insurance Conference. President and Chief Financial,Officer ... is,scheduled to make a presentation on September 3, 2008, ... Cloninger will discuss the,company,s outlook for the remainder of ...
... wages and benefits, HEMET, Calif., Aug. 27 The ... against the,board of directors of Valley Health System (VHS) for ... already voted to agree to., "I do this job ... said,Lisa Howell, a registered nurse at Menifee Valley Medical Center. ...
... HARRISBURG, Pa., Aug. 27 Believe it or not,women ... women,s oral,health needs change at different stages throughout their ... Association (PDA) offers a reminder that,understanding these evolving oral ... stage of life, is getting the oral health care ...
... help regain pre-pregnancy body, IRVINE, Calif., ... of post-baby body shaping solution VelaShape(TM),and other ... body,contouring, today reveals the results of the ... women,s desire to regain their,pre-pregnancy body. Syneron ...
... not all part of normal aging process , , WEDNESDAY, Aug. ... women who remain free of dementia will nonetheless undergo an ... years before their death, a new study reveals. , Verbal ... of this cognitive decline, which is not, the researchers stressed, ...
... women quit smoking during pregnancy to protect their unborn children from ... a few months of giving birth. , By shedding light ... that cigarette for good, a study by researchers at the University ... to help women quit and stay quit. , According to the ...
Cached Medicine News:Health News:Aflac Incorporated To Present at the Keefe, Bruyette & Woods 2008 Insurance Conference 2Health News:State Board Issues Complaint: VHS Board Should Have Signed Contract With Caregivers 2Health News:What You Need to Know About Women's Oral Health 2Health News:Celebrity Moms' Post-Baby Body Triggers Jealousy, Skepticism in U.S. Moms 2Health News:Celebrity Moms' Post-Baby Body Triggers Jealousy, Skepticism in U.S. Moms 3Health News:Celebrity Moms' Post-Baby Body Triggers Jealousy, Skepticism in U.S. Moms 4Health News:Mental Skills Can Decline Years Before Dying 2Health News:Mental Skills Can Decline Years Before Dying 3Health News:Newly-defined factors may prevent postpartum smoking relapse 2Health News:Newly-defined factors may prevent postpartum smoking relapse 3
(Date:8/21/2014)...   Royal Philips (NYSE: ... received 510(k) clearance from the U.S. Food and ... for Transcatheter Aortic-Valve Implantation (TAVI) treatments. Through 3D ... pre-procedural, high-precision positioning to treat aortic stenosis ailments.  ... available as part of Philips IntelliSpace Portal ...
(Date:8/21/2014)... JOSE, Calif. , Aug. 21, 2014  SI-BONE, ... medical device company that pioneered the use of the ... (MIS) device indicated for fusion of the sacroiliac (SI) ... ) published an update to its Lumbar Fusion Medical ... SI joint fusion procedure.  The policy states that the ...
(Date:8/21/2014)... 2014   Auxilium Pharmaceuticals, Inc. (NASDAQ: ... today announced positive results from a randomized, double-blind ... CCH) for the treatment of edematous fibrosclerotic panniculopathy ... 2a trial, all three doses of CCH (low ... improvement in the appearance of cellulite as measured ...
Breaking Medicine Technology:Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 3SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 2SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 2Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 4Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 5Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 6Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 7
... May 9 Osteoarthritis is a,painful and ... people in the United States. It is ... The novel investigational pain medication,tapentadol, a centrally ... with joint-disease pain, compared to those treated ...
... Biosciences, Inc.,(Nasdaq: RDEA ), a company focused ... for the treatment of HIV, cancer and,inflammatory diseases, ... been appointed Senior Vice President, Finance and Operations ... will resign from our board of,directors shortly thereafter. ...
Cached Medicine Technology:Results of Phase 3 Study Show Tapentadol IR Relieves Acute Pain and Offers Favorable Gastrointestinal Tolerability Profile 2Results of Phase 3 Study Show Tapentadol IR Relieves Acute Pain and Offers Favorable Gastrointestinal Tolerability Profile 3Results of Phase 3 Study Show Tapentadol IR Relieves Acute Pain and Offers Favorable Gastrointestinal Tolerability Profile 4Results of Phase 3 Study Show Tapentadol IR Relieves Acute Pain and Offers Favorable Gastrointestinal Tolerability Profile 5Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results 2Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results 3Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results 4Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results 5Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results 6
... Mikro-Tip pressure intravascular catheters provide a ... of measuring pressures in the heart ... Mikro-Tip catheters are ideal for high ... in size from 2 to 7 ...
... Millar Mikro-Tip pressure intravascular catheters provide ... method of measuring pressures in the ... thromboresistant Mikro-Tip catheters are ideal for ... range in size from 2 to ...
... Intravascular Mikro-Tip Pressure Catheters; Millar manufactures ... pressure sensor catheters for simultaneous high ... suitable for measuring pressure gradients across ... a vascular stenosis. The catheters are ...
... the United States dying from Sudden Cardiac Death ... recommended that AEDs be used as a standard ... Any AED can provide a life-saving shock during ... continuous monitoring capabilities during and after resuscitation. Plus ...
Medicine Products: