Navigation Links
Iowa State chemists track how drug changes, blocks flu virus
Date:2/1/2008

AMES, Iowa An anti-virus drug attacks influenza A by changing the motion and structure of a proton channel necessary for the virus to infect healthy cells, according to a recently published research paper by two Iowa State University chemists.

Mei Hong, Iowa States John D. Corbett Professor in Chemistry, and Sarah Cady, a graduate student in chemistry, are studying the effects of the antiviral drug amantadine on influenza A. Thats the type of flu bug that most commonly makes people sick and the one that has caused the most serious flu epidemics.

Their findings appear in the Feb. 5 edition of the Proceedings of the National Academy of Sciences.

Hong said the findings are particularly important because mutations of the type A virus are resistant to amantadine treatment.

In the last few years, amantadine resistance has skyrocketed among influenza A viruses in Asia and North America, making it imperative to develop alternative antiviral drugs, Hong and Cady wrote in their paper.

To develop those drugs, Hong said researchers first need to understand exactly how amantadine stops the flu virus.

First, some background about how a flu virus infects a healthy cell: A virus begins the process by attaching itself to a healthy cell. The healthy cell surrounds the flu virus and takes it inside the cell through a process called endocytosis. Once in the cell, the virus uses a protein called M2 to open a channel to the healthy cell. Protons from the healthy cell flow through the channel into the virus and raise its acidity. That triggers the release of the virus genetic material into the healthy cell. The virus hijacks the healthy cells resources and uses them to reproduce and spread the virus.

If the M2 proton channel is blocked, the process doesnt work and a virus cant infect a cell and spread.

Hong and Cady studied the proton channel with the help of solid-state nuclear magnetic resonance spectroscopy a technique similar to the magnetic resonance imaging technology that takes pictures of soft tissues in the body. The technology enabled them to discover and describe the motion and structure of the M2 proton channel in virus cells. They studied the channel when cells were treated with amantadine and when they were not.

Hong said the study made three findings:

  • First, the M2 protein is in constant motion, changing among various conformations, and amantadine treatment changes the rate of motion and reduces the number of possible conformations the protein can adopt.

  • Second, the structure of the protein changes most prominently at two places facing the channel interior when cells are treated with amantadine.

  • And third, the tilt and orientation of the proteins helices are subtly changed by amantadine.

And all that blocks the ability of a virus to infect a healthy cell.

We didnt know that before, Hong said. And now that makes it very clear what we should study next.

Hongs next step is to examine how mutant versions of the virus are able to resist the flu-stopping changes caused by amantadine. Hong said that study will depend on winning research funding and recruiting graduate students interested in chemistry with biological applications.


'/>"/>

Contact: Mei Hong
mhong@iastate.edu
515-294-3521
Iowa State University
Source:Eurekalert  

Related medicine news :

1. Sharing Miracles Television Program to Feature North Carolina State Womens Basketball Coach Kay Yow
2. Obesity Action Coalition Calls on the State of Mississippi House of Representatives to Withdraw House Bill 282 Discriminating Against Those Affected by Obesity
3. Experimental Vaccine Halts Prostate Cancer in Mice
4. MedWaves, Inc. Announces Receipt of United States Food and Drug Administration 510k Clearance to Market Its Patented Microwave Coagulation/Ablation System
5. CAHI Releases Updated Health Insurance Mandates in the States
6. Los Angeles Daily Journal Names Richardson & Patel Verdict Top in the State of California for 2007
7. SAFC Pharma Expands Its Pharmorphix Solid State Chemistry Services
8. Researchers investigate links between prostate, cadmium, zinc
9. Pennsylvania Education Secretary Lauds Action on Measure to Create Statewide School Health Benefits System
10. Urinary dysfunction troubles men who undergo prostate removal
11. Capital BlueCross CEO Says Meaningful Statewide Competition Must Be Key Criteria in Pennsylvanias Review of Proposed Highmark-IBC Merger
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iowa State chemists track how drug changes, blocks flu virus
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
Breaking Medicine Technology: