Navigation Links
Iowa State University researcher identifies eye disease in canines
Date:3/4/2008

AMES, Iowa -- Sinisa Grozdanic, assistant professor of veterinary medicine at Iowa State University, has identified and named an eye disease not previously known. The disease, Immune-Mediated Retinopathy, or IMR, causes loss of function in retinal cells and, in some cases, blindness in canines.

Grozdanic's findings are published in the March edition of Veterinary Clinics of North America: Small Animal Practice.

IMR is very similar to a previously known malady called Sudden Acquired Retinal Degeneration Syndrome or SARDS.

Both diseases occur when the dog produces auto antibodies that attack the retinal cells. The antibodies mistake retinal cells for cancerous tumors or tissues that need to be destroyed.

In the process of attacking the retinal cells, the auto antibodies cause the retinal cells to lose function and the dog to lose some or all of its vision.

The difference between IMR and SARDS that Grozdanic identified is that the auto antibodies that attack the retinal cells in SARDS patients are produced in the eye. In the newly identified IMR, Grozdanic found that these auto antibodies are produced elsewhere in the dog and travel to the eyes in the blood.

This is a critical step in treating the disease because the source of the problem is better understood, according to Grozdanic.

"The whole purpose is to start to understand the disease better," he said. "The more we understand these diseases, the more proficient we will be developing new treatments."

Grozdanic says the evidence shows that approximately 2,000 cases of SARDS occur every year. Some of those cases may now be identified as IMR, and treated differently.

Treatment for IMR can have a relatively high success rate.

"In approximately 60 percent of the Immune-Mediated Retinopathy cases, we have been able to treat it," he said. "In some cases very successfully, in some cases moderately successfully."

Since IMR has only recently been identified, there are no statistics on how many dogs this disease affects.

Grozdanic has also developed a test to differentiate the two types of retinopathy. Grozdanic shines colored lights in the dog's eyes to see if the pupils constrict. If the pupils constrict poorly while the doctor uses the red light, and have normal constriction when blue light is used, the patient most likely suffers from IMR. If the eyes respond to blue lights, but not red lights, then the diagnosis is SARDS.

Tests show SARDS-affected eyes have almost no electrical activity. IMR-affected eyes have some electrical activity, and the retinal cells are not destroyed but have only lost function. These are the retinal cells that Grozdanic thinks can function again now that the origin of the problem is known.

In his work with canine patients with IMR during the past few years, Grozdanic has restored sight in several dogs.

According to Grozdanic, these two diseases are similar to illnesses that afflict humans, so treatment for people may not be far off.

"This was a giant leap. We are getting better at understanding it, and based on this information, we may be able to modify and improve treatment of dogs and eventually human patients," said Grozdanic.


'/>"/>

Contact: Sinisa Grozdanic
sgrozdan@iastate.edu
515-294-4900
Iowa State University
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. First biomarker discovered that predicts prostate cancer outcome
3. Frequent Prostate Screens Fail to Improve Aggressive Cancer Diagnoses
4. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
5. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
6. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
7. 4-Star Gen. Barry Mccaffrey, Former U.S. Drug Czar, to Keynote Recovery Happens! Rally for Treatment: Wed., Sept. 5, 11 Am, State Capitol West Steps, Sacramento
8. Expert on Emerging Infectious Zoonotic Diseases Joining K-State as a Regents Distinguished Professor
9. Red wine compound shown to prevent prostate cancer
10. Coalition for Pulmonary Fibrosis Launches Aggressive Ad Campaign Directed at United States Congress
11. PA Secretary of Public Welfare Responds to Warren State Hospital Closure Rumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being ... Block Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for ... of Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this informative ...
(Date:2/5/2016)... ... , ... After years as an active staff surgeon and having served as ... Wayne Carman transitioned to chief of the Division of Plastic Surgery at what is ... chief and began a second three-year term in January of 2016. , The original ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know ... having to wait longer to access the treadmills. It’s a predictable trend. After the ... lose weight and get in shape by joining gyms, starting new walking or running ...
(Date:2/5/2016)... Georgia (PRWEB) , ... February 05, 2016 , ... Dr. ... to announce their 2nd Annual No Cost Dental Day to individuals in need. The ... The purpose of this No Cost Dental Day is to provide dental care to ...
(Date:2/5/2016)... ... February 05, 2016 , ... Health and wellness is a topic that should ... event they are experiencing an illness. Migraines are a severe form of a headache ... migraines would not wish the pain on their worst enemy, the feeling can last ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  Aralez Pharmaceuticals Inc. ... of POZEN Inc. ("POZEN") and Tribute Pharmaceuticals Canada Inc. ("Tribute") ... and shareholders of Tribute. The combined company will operate ... company with operations in Canada , ... United States . Under the terms of the ...
(Date:2/5/2016)... February 5, 2016 --> ... report states that the global active pharmaceuticals ingredients (APIs) ... predicted to reach US$185.9 bn by 2020. It is ... 2014 to 2020. The title of the report is ... by Geography, and by Therapeutic Area) - Global Industry ...
(Date:2/5/2016)... Feb. 5, 2016  Henry Schein, Inc. (NASDAQ: HSIC ... and services to office-based dental, animal health and medical ... agreement to acquire a majority ownership interest in Dental ... in Brazil . ... Dental Cremer is the dental distribution business of Cremer ...
Breaking Medicine Technology: