Navigation Links
Ion channel responsible for pain identified by UB neuroscientists
Date:12/17/2010

nges. This sensitization causes a state of "hyperalgesia," or increased sensitivity to pain.

"Merely touching the inflamed area can be very painful," notes Bhattacharjee. "The ionic mechanisms that are chiefly responsible for this inflammatory-mediated change in nociceptive firing had not been clearly identified.

"We were able to demonstrate that a certain class of potassium channels is removed from the surface of nociceptive cells during inflammatory signaling. The removal of these ion channels is linked to the hypersensitivity of these nerve cells. We demonstrated that reducing the expression of these channels by gene interference techniques produced a similar nociceptor hyperexcitability. "

Bhattacharjee says his team plans to extend their ion channel "trafficking" studies to in vivo models, using peptide inhibitors to try to prevent the removal of the potassium channels from the surface of nociceptors during inflammation.

"We expect to show that maintaining these channels at the surface during inflammation will be effective for pain relief. Successful completion of our studies will provide the impetus for direct human clinical trials. Megan O. Nuwer, PhD, and Kelly E. Picchione, PhD, both in the neuroscience program, are co-authors on the paper.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Report: The Internet Has More Influence Over Consumer Health Actions than Traditional DTC Channels
2. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
3. 29 Clear Channel stations Nationwide Raise Nearly $2.8 Million to Help Save the Lives of Kids Fighting Cancer and Other Deadly Diseases
4. Lakeside Medical Group, Heritage Provider Network, CEO Dr. Richard Merkin, Featured on Several Segments of Fox National News and Fox Business Channel on Current Healthcare Payment Structures to Physicians
5. Changing channels to eliminate chronic pain
6. LoveToKnow.com Launches Gluten Free Channel and Will Donate to National Foundation for Celiac Awareness
7. Clear Channel's “Penn Project” Features Dr. Barry Sears, Zone Diet Creator, About Obesity in America
8. Shadow Technology Slashes Cost of IP Call Management Software By $450 for 5 Channels
9. International News Channel Profiles Egg Donor Surrogacy USA
10. Channeling efforts to fight cystic fibrosis
11. Mayo Clinic responsible for $22 billion in economic impact, including $9.6 billion in Minnesota
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Ariz. (PRWEB) August 28, 2014 Arizona ... Force Impact Technologies , has been named one of ... the Year competition. , This is the fourth consecutive ... in the competition. Jared Schoepf, co-founder of SafeSIPP, and ... 2013 and 2012, respectively. In 2011, ASU dominated the ...
(Date:8/28/2014)... Reinberg HealthDay Reporter THURSDAY, ... the diet may worsen symptoms of multiple sclerosis (MS), a ... MS, such as vitamin D, smoking and Epstein Barr virus ... another environmental factor affecting MS patients," said lead researcher Dr. ... in Buenos Aires. Multiple sclerosis is a disease of ...
(Date:8/28/2014)... and Ann Arbor, MI (PRWEB) August 28, 2014 ... company and the nation’s leading intraoperative neurophysiology monitoring ("IONM") ... and CFO, to the position of Chief Executive Officer ... CFO, was promoted to President and CFO in 2013 ... growth and success. , “Bill’s efforts and achievements ...
(Date:8/28/2014)... Mount Vernon, Ind. (PRWEB) August 28, 2014 ... subsidiary of Valero Energy Corporation (NYSE: VLO), and the ... other state and local officials today at a Port ... recently purchased Mount Vernon ethanol plant. , “The opening ... Indiana-Mount Vernon is another economic development win for ...
(Date:8/28/2014)... Norton HealthDay Reporter THURSDAY, ... sending electrical currents through the scalp to a specific network ... a day. In a small study of healthy young ... certain networks involved in memory. That, in turn, boosted participants, ... after the brain stimulation. During TMS, an electromagnetic coil ...
Breaking Medicine News(10 mins):Health News:Arizona State University Grad Student in the Running for College Entrepreneur of the Year 2Health News:Arizona State University Grad Student in the Running for College Entrepreneur of the Year 3Health News:Could Too Much Salt Harm MS Patients? 2Health News:Could Too Much Salt Harm MS Patients? 3Health News:Biotronic NeuroNetwork Announces the Promotion of Bill Gecsey to CEO 2Health News:Valero, Ports of Indiana Celebrate Restart of Ethanol Plant 2Health News:Valero, Ports of Indiana Celebrate Restart of Ethanol Plant 3Health News:Electrical Pulses to Scalp May Boost Memory: Study 2Health News:Electrical Pulses to Scalp May Boost Memory: Study 3
... developing clothing, which they say will be able to monitor ... sensors designed to monitor body fluids such as blood and ... use the clothes to check on groups such as recovering ... ,As of now, the Biotex programme, which is ...
... of psychologists from Durham University and two Polish institutions ... their fathers are more likely to select partners ... negative or less positive relationships were not attracted to ... ,Due to be published in the July issue of ...
... total economic shutdown as some 2 million public servants ... 'It's going to be a total shutdown tomorrow in public ... involving marches in major cities and pickets outside government buildings,' ... Trade Unions (COSATU) labor federation had warned Tuesday. ...
... (CNBG) led by Madam Wang Lifeng, President and CEO ... Union Minister for Health & Family Welfare , Dr. ... CNBG is Government owned, the largest vaccine manufacturer and ... discussed the supply live of JE vaccine in order ...
... than leave you short-tempered: it can also stress your ... death, according to a study released Wednesday . ... sleep loss have been well-documented, ranging from lowered concentration ... by researchers at the University of Pennsylvania School of ...
... both houses of the Legislature are on the brink of ... the Assembly's bill is Manhattan Assemblyman Richard Gottfried , who ... serious medical conditions who could have a better quality and ... a person would have to have a debilitating or life-threatening ...
Cached Medicine News:Health News:Scientists Developing 'intelligent Clothes' to Monitor Wearer's Health 2Health News:Women Choose Their Men With Their Fathers Resemblance 2Health News:South Africa Facing Major Economic Shutdown as Health Workers are Sacked En Masse 2Health News:Chinese Delegation Meets Health Minister Regarding Japanese Encephalitis Vaccine Supply 2Health News:Insufficient Sleep Increases Risk of Cardiovascular Disease: Study 2Health News:Medical Marijuana to Be Legalized 2
(Date:8/28/2014)... -- In recognition of the increased risks that seniors ... pneumonia, shingles and other illnesses, CVS/pharmacy ® ... be Senior Vaccination Month. Because people,s immune systems ... adults ages 65 years and older stay up ... MinuteClinic nurse practitioners and physician assistants will be ...
(Date:8/28/2014)...  Stryker Orthopaedics, the Official Joint Replacement Products of the ... joint health to golf fans at the next stop of ... Championship. The company,s fan destination – "The Stryker Mobility Zone" ... at the TPC Boston in Norton, MA ... At the Deutsche Bank Championship, Stryker will be providing ...
(Date:8/28/2014)... Aug. 28, 2014  Critical Process Filtration, Inc. ... today announces the expansion of their Technical Services ... Filtration now offers customers and potential customers services ... filter failure analyses (even for competitor filters) and ... hallmark services of system benchmarking and cost/performance optimization. ...
Breaking Medicine Technology:September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 2Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 3Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 4Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 5Critical Process Filtration, Inc. Announces Expanded Technical Services and Validation Support 2
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
Medicine Products: