Navigation Links
Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
Date:8/13/2007

sixfold increase in cases during the past 30 years, according to the National Cancer Institute.

Understanding how and why the cells change in some cases and not others has been a major challenge for investigators.

Researchers compared telomere length and telomerase activity in biopsy specimens from 38 patients with GERD and 16 control patients. This new line of research suggests that the continuous acid bath affecting esophageal cells causes them to divide more frequently in order to regenerate the damaged lining. However, each time the cells divide, the telomeres at the end of DNA become shorter. When they become too short, the aging cell can no longer divide, Dr. Souza said.

Scientists suspect that when cells can no longer divide, other cells might infiltrate the area to make up for the loss. And those cells may be more likely to generate the acid-resistance that makes them more likely to turn cancerous.

If the telomeres get short enough, maybe the cells cant regenerate any more and maybe thats why you start to see this change, said Dr. Spechler. Perhaps the esophagus cant regenerate the normal skin-like squamous cells, and instead, it has to recruit cells from somewhere else and thats why you start getting these changes to intestinal-like cells.

Other studies by this group of UT Southwestern digestive disease specialists suggest the alternate cells that eventually take over might be bone-marrow cells.

There could be cells circulating from the bone marrow that wouldnt ordinarily end up in the esophagus. But if you shorten the telomeres enough and the esophagus cant regenerate anymore, perhaps these bone-marrow cells might have to replace that tissue, and bone-marrow cells can turn into intestinal tissue, Dr. Spechler said. This hasnt been proven, but we have some data that supports that.

In research available online prior to printing this month in Diseases of the Esophagus, Drs. Souza, Spechler and co
'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Investigators Find Poisonous Chemicals In Four More Drugs In China
2. Wrestler Chris Benoits Son was Sedated - Says Investigators
3. Mystery behind Preeclampsia uncovered
4. Uncovering a gene for oesophagal cancer
5. Syphilis uncovered
6. A Simple Exercise Can Uncover Undiagnosed Asthma
7. Mystery of nacrolepsy uncovered
8. Hospitals Health Insurance Scam Uncovered
9. Grapefruit juice could be taken along with medication: the nutrient-drug reaction uncovered!
10. New Diagnostic Tool Uncovered Gene Expression Patterns in Recessive Genetic Disorders
11. Scientists Uncover The Secret Behind The Speed In Nerve cells Conduction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... Vancouver, BC (PRWEB) November 27, 2014 ... physiotherapy clinic, has recently announced that its personalized ... world-class treatment techniques can help victims of sports ... tendinopathy, shin splints, or patellofemoral pain syndrome, Absolute ... of runner’s and jumper’s knee, ACL tears, meniscal ...
(Date:11/27/2014)... November 27, 2014 Blood-borne pathogens raise ... medical precautions and procedures in place to counter this. ... disposal of things tainted with menstrual blood are taken ... a simpler, more sanitary way to handle tampons and ... inventor from Sonora, Calif. , He then created a ...
(Date:11/27/2014)... News) -- Most babies and young children don,t need ... and Drug Administration says. Over-the-counter (OTC) cold and ... than 2 because they could cause serious and potentially ... average about three colds a year, but children get ... might want to give them pain relievers, decongestants and ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 Jeffrey ... years in the Charlotte area providing audits, reviews, ... services to businesses of varying size across numerous ... owners to meet all of their accounting and ... through the QuickBooks ProAdvisor Program. When asking Mr. ...
(Date:11/27/2014)... November 27, 2014 “Wekho” was featured on ... latest and coolest mobile applications on the iOS, Android, and ... of NewsWatch, conducted the app review and shared ... of people. , An interesting new way to travel and ... Android devices. It’s called Wekho and it’s a free ...
Breaking Medicine News(10 mins):Health News:Coquitlam Physiotherapy Clinic Now Helps Clients Reach Pre-Injury State 2Health News:Steer Clear of Cold Meds for Babies, FDA Advises 2Health News:Jeffrey Carlini becomes Intuit Proadvisor and receives QuickBooks certification 2Health News:A New Geolocation Mobile Application and was Featured on NewsWatch Television on October 30, 2014 2
... your thoughts validated by others brings mental satisfaction, study finds ... with others often leads to a sense of satisfaction, and ... the "reward" area of the brain is activated when people ... and Denmark used functional MRI scans to monitor activity in ...
... caused mice to develop disease, study finds , THURSDAY, June ... have found a bacteria living in the gut may trigger ... The gut of all mammals is populated with thousands of ... developing a normal immune system. But some of these bacteria ...
... ... health and wellness. Learn how to improve the look and strength of your abdominal muscles ... information provided on this new Web site. , ... (PRWEB) June 17, 2010 -- A new Web site has been developed to help anyone ...
... ... (ENTA) is pleased to announce the addition of Brian Safier, MD, Allergist/Immunologist, who will join ... ... , LLP (ENTA) is pleased to announce the addition of Brian Safier, MD, Allergist/Immunologist, who ...
... Compliance Advisory ... and the University of Virginia School of Medicine. , ... Charlottesville, VA, San Francisco, CA, New York, NY and Paris, France ... sciences, openQ has formed a Compliance Advisory Board. Board members include experienced veterans from ...
... there are now new areas in which whole body magnetic ... of Deutsches rzteblatt International ( Dtsch Arztebl Int ... a review of possible uses, together with the limits of ... suitable for routine use in hospitals, as the procedure takes ...
Cached Medicine News:Health News:Shared Opinions Light Up Brain's 'Reward Center' 2Health News: Stomach Bacteria Might Trigger Rheumatoid Arthritis 2Health News: Stomach Bacteria Might Trigger Rheumatoid Arthritis 3Health News:New Web Site Provides Helpful Exercise and Nutrition Tips 2Health News:ENT and Allergy Associates Continues to Bolster Bayside Presence and Expertise, Adds Allergist/Immunologist Dr. Brian Safier, 2Health News:ENT and Allergy Associates Continues to Bolster Bayside Presence and Expertise, Adds Allergist/Immunologist Dr. Brian Safier, 3Health News:openQ Announces the Formation of a Compliance Advisory Board 2Health News:openQ Announces the Formation of a Compliance Advisory Board 3
(Date:11/26/2014)... 26, 2014  BioScrip ® , Inc. (NASDAQ: BIOS ... Chief Executive Officer, will present at the Bank of America Merrill ... , , Date: , , , Wednesday, December 3, 2014 , ... , , , , Location: , , , Boca Raton ... BioScrip, Inc. BioScrip, Inc. is a leading ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, Inc., ... novel therapies for infectious diseases, announced today the ... internationally recognized key opinion leader in the areas ... advisory board. Founder and Chief Executive ... believe Dr. Opal,s extensive experience investigating bacterial toxins ...
(Date:11/26/2014)... -- At the American Dental Association,s Annual Meeting in ... Group was honored to be part of the 2014 ... see and test the Best of Class winners and ... the latest developments in dental technology. This year, featured ... Caries Detection Device and Kerr Demi ™  Ultra ...
Breaking Medicine Technology:Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3
... Fla., Sept. 27, 2011 Nuance Health today announced ... conducted on their innovative product, Swype Cold & Flu ... The clinical study, conducted on 103 volunteers ... the effectiveness, tolerability, and willingness of participants to use ...
... China, Sept. 27, 2011 /PRNewswire-Asia/ -- China Health Resource, ... Chinese Medicine (TCM) products, announced robust quarterly earnings for ... and $1.7 million in net income, 443% increase from ... of about $0.02 per share for the first half ...
Cached Medicine Technology:Swype Cold & Flu Shield Significantly Reduces Occurrence of Colds in Clinical Study 2China Health Resource, Inc. Announces Record 2nd Quarter 2011 Results 2China Health Resource, Inc. Announces Record 2nd Quarter 2011 Results 3
... Center combines the real-time monitoring surveillance ... clinical analysis tools. Moreover, the Information ... portal technology so that monitoring data ... with digital radiology images, archived data, ...
... CryoTherapy system uses catheters that are ... refrigeration console. The console processes the ... distal tip of the catheter, creates ... through an easy-to-use touch-screen interface. From ...
... tasks and delivers consistently reliable ... and ensure testing accuracy in ... automated reticulocyte counts and three-dimensional ... sensitivity, specificity and efficiency in ...
... enterprise-wide staff scheduling solution that streamlines ... through the synchronization and interface of ... and maintains staff schedules and replacements; ... manages shift and work location schedules; ...
Medicine Products: