Navigation Links
Investigational malaria vaccine found safe and protective
Date:8/8/2013

An investigational malaria vaccine has been found to be safe, to generate an immune system response, and to offer protection against malaria infection in healthy adults, according to the results of an early-stage clinical trial published Aug. 8 in the journal Science.

The vaccine, known as PfSPZ Vaccine, was developed by scientists at Sanaria Inc., of Rockville, Md. The clinical evaluation was conducted by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and their collaborators at the Walter Reed Army Institute of Research and the Naval Medical Research Center, both in Silver Spring, Md.

Malaria is transmitted to humans by the bite of an infected mosquito. After the bite occurs, infectious malaria parasites in the immature, sporozoite stage of their life cycle first travel to the liver, where they multiply, and then spread through the bloodstream, at which time symptoms develop.

The PfSPZ Vaccine is composed of live but weakened sporozoites of the species Plasmodium falciparum, the most deadly of the malaria-causing parasites.

"The global burden of malaria is extraordinary and unacceptable," said NIAID Director Anthony S. Fauci, M.D. "Scientists and health care providers have made significant gains in characterizing, treating and preventing malaria; however, a vaccine has remained an elusive goal. We are encouraged by this important step forward."

The Phase I trial, which took place at the NIH Clinical Center in Bethesda, received informed consent from and enrolled 57 healthy adult volunteers ages 18 to 45 years who never had malaria. Of these, 40 participants received the vaccine and 17 did not. To evaluate the vaccine's safety, vaccinees were split into groups receiving two to six intravenous doses of PfSPZ Vaccine at increasing dosages. After vaccination, participants were monitored closely for seven days. No severe adverse e
'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Investigational agent targets gene signaling pathways to improve response for patients with CLL
2. Method patent issued for investigational new class of pain medication
3. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
4. New process would make anti-malarial drug less costly
5. UCI researchers create mosquitoes incapable of transmitting malaria
6. The math of malaria
7. Novel anti-malarial drug target identified
8. New research reveals extent of poor-quality antimalarial medicines in South American countries
9. BioMed Central presents Challenges in Malaria Research: Progress Towards Elimination
10. Novel technique demonstrates interactions between malaria parasite and HIV
11. Meddling with male malaria mosquito mating plug to control an epidemic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... B. E. Smith, the only full-service leadership ... retained to lead a national chief financial officer ... The top executive search firm in the healthcare industry, ... healthcare executives into organizations. , Johnson Memorial Hospital ... to the residents of Johnson County and the surrounding ...
(Date:12/19/2014)... December 19, 2014 Novellus Healthcare ... Care: Pharmacy & Clinics™, an independent journal that ... treating and caring for patients inside the pharmacy ... expands to provide optimal access to quality care, ... forum for the team treating and coordinating patient ...
(Date:12/19/2014)... 2014 Pain Free Living a leader ... announce a new Superior magnetic necklace using ... the strongest neodymium magnets for the fastest pain relief ... the Superior Magnetics brand for the fastest relief by ... magnetic therapy using Superior Magnetic Jewelry at fairs and ...
(Date:12/19/2014)... December 19, 2014 From November 24, 2014, ... training for the year 2014 in its Goa retreat ... year. Through the Indian winters, from November to March, Siddhi ... beautiful beach of Arambol, Goa. The Goa training sessions will ... intakes of yoga teacher training, the 10th intake is also ...
(Date:12/19/2014)... December 19, 2014 After a 13-year ... is again returning to the stage to entertain his ... for concert performances, and the successful tour has been ... announced. , Visit Ticketability.com for a ... Detroit shows at fair prices. , Music fans have ...
Breaking Medicine News(10 mins):Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 2Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 3Health News:New Superior Magnetic Necklace Relieves Migraine Headache 2Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 2Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 3Health News:Garth Brooks Tickets for Joe Louis Arena: Ticketability.com Becomes a Popular Destination for Discount Tickets for Garth Brooks’ Detroit Concerts Set for February 27-28 2
... United Kingdom: Cleaning is doubly beneficial, for it ensures two ... mentally cleanses the cleaner //(Lady of the House!) Women, spoke ... put things in order, but the flip side to it, ... ‘cleaning’ became so obsessive that they could be called “Cleanoholics” ...
... Society for Women's Health Research has found that 62 percent ... symptom occurs more in women than in men and is ... ,Some of the changes that occur are like burning, ... to light. The survey quizzed 304 women ages 45 to ...
... lot of ground work has to be done along with the ... who lack health insurance.// It is one of growing issues and ... County, US is at the epicenter of this huge medical crisis. ... in the country. This poses a severe set back both in ...
... embedded in a tribal’s chest two weeks ago. Till the ... was moving around normally as if nothing has happened. ... 7 by an arrow by fellow tribesman Kaliya when he ... pulled out the stem of the arrow, the head remained ...
... a chance to learn yoga, as Haryana is planning to ... ,State Education Minister Phool Chand Mullana said he ... itself. ,Mullana, who attended Ramdev's yoga training camp ... consultations would be held with the spiritual guru to train ...
... have not lessened the pain of losing their mentally ... his wife Meenakshi to run free counselling// sessions here ... ,The Trivedis were shattered when seven-year-old Ammi died ... her, but nothing helped. After her death, the couple ...
Cached Medicine News:Health News:Health Insurance Fueling Medical Crisis in US 2Health News:Distressed Couple Assists Parents Of Mentally Challenged Kids 2
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, ... (CTMC), and Integrated Clinical Trial Services, LLC (ICTS), ... for clinical trials announce that they have formed ... Services (i-CTMS). i-CTMS will provide a broad range ... biotechnology and medical device companies. i-CTMS ...
(Date:12/15/2014)... 12, 2014 Research and Markets ( ... "Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram Devices ... 2016. The North America accounts ... while Europe claims approximately 27% ...
(Date:12/15/2014)... YORK and HERZLIYA PITUACH, Israel ... "Company") (NASDAQ: IMNP ) announced today that its ... the Board succeeding Dr. Daniel Teper who continues ... a member of Immune,s Board of Directors since 2013. ... "I am delighted to represent the interest of shareholders and ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4
... LAKE, N.J., Jan. 3, 2012  Arena Pharmaceuticals, Inc. (NASDAQ: ... has submitted its response to the Complete Response Letter (CRL) ... review of the lorcaserin New Drug Application (NDA). Lorcaserin is ... weight loss, in patients who are obese (Body Mass Index, ...
... Jan. 3, 2012 IDEXX Laboratories, Inc. (NASDAQ: ... 30 th Annual J.P. Morgan Healthcare Conference. Jonathan W. ... on the Company on Monday, January 9, 2012 at 2:30 ... California. Individuals can access the live audio webcast of the ...
Cached Medicine Technology:Arena Submits Response to FDA Complete Response Letter for Lorcaserin 2Arena Submits Response to FDA Complete Response Letter for Lorcaserin 3Arena Submits Response to FDA Complete Response Letter for Lorcaserin 4Arena Submits Response to FDA Complete Response Letter for Lorcaserin 5Arena Submits Response to FDA Complete Response Letter for Lorcaserin 6
Porous foundation 470 series....
The Opteon stem meets the challenge of providing a high-quality, cost-effective hip implant for the moderate demand patient....
Exactech's AcuMatch C-Series (cemented femoral stem) is designed to provide solutions to the problems which compromise both the short and long term successful outcome of cemented hip arthroplasty....
The link ribbed hip stem for cementless primary hip replacement surgery....
Medicine Products: