Navigation Links
Investigational drug tested for preventing muscle fiber death in muscular dystrophy
Date:3/16/2008

CINCINNATI An investigational antiviral drug currently undergoing human trials in Europe for treating Hepatitis C infections may have potential to reduce muscle cell damage in Duchenne and other forms of muscular dystrophy (MD). A research team led by Cincinnati Childrens Hospital Medical Center reported their results using three different mouse models of MD in a letter posted online March 16 by the journal Nature Medicine.

The investigational drug, Debio-025, is a known inhibitor of the protein cyclophilin D, which regulates the swelling of mitochondria in response to cellular injury. Researches decided to test the drug in mice engineered to carry MD after earlier laboratory tests showed deleting a gene that encodes cycolphilin D reduced swelling and reversed or prevented the diseases muscle-damaging characteristics. The mice were engineered as models of Duchenne muscular dystrophy and forms caused by a deficiency of two structural proteins, delta-sarcoglycan and laminin alpha2.

Similar to deleting the gene encoding cyclophilin D, we found that treatment with Debio-025 reduced mitochondrial swelling and necrotic manifestations in mice with muscular dystrophy. This is why we believe inhibiting cyclophilin D could be a new treatment strategy, said Jeff Molkentin, Ph.D., corresponding author of the study and a researcher in the Division of Molecular Cardiovascular Biology at Cincinnati Childrens. Debio-025 has already passed Phase II clinical trials in Europe and is considered safe in people, so we want to explore the possibility of conducting clinical trials in patients with Duchenne MD.

During the onset of muscular dystrophy, the loss of certain proteins critical to muscle function such as dystrophin can lead to contraction-related micro-tears in muscle fibers and an influx of calcium around muscle tissue. When this happens, cyclophilin D is instructed to make the membranes of mitochondria more permeable. This causes mitochondria t
'/>"/>

Contact: Nick Miller
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Enrollment completed in 2 pivotal phase III studies of the investigational cancer drug vandetanib
2. New Drug Application Submitted to FDA for Investigational Analgesic Tapentadol Immediate Release Tablets
3. UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
4. SGX Pharmaceuticals Submits Investigational New Drug Application for SGX523, a Highly Potent, Selective, Orally Bioavailable cMET Inhibitor
5. MetaCure(TM) Launches Investigational Study of Gastric Stimulator for Patients With Type 2 Diabetes Who are Overweight
6. Abbotts Investigational SIMCOR(R) Offers Comparable LDL Lowering to Simvastatin and Significantly Raises HDL and Lowers Triglycerides in Phase III Study
7. Dynavax and Merck & Co., Inc. Announce Partnership to Develop HEPLISAV(TM), an Investigational Hepatitis B Vaccine Currently in Phase 3
8. Ono and Medarex Announce Allowance of Investigational New Drug Application for Fully Human Anti-PD1 Antibody
9. Supratek Pharma Inc. announced today that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for SP1049C for the treatment of metastatic adenocarcinoma of the upper gastrointestinal tract
10. Accentia announces investigational new drug application for Revimmune for refractory MS
11. FDA Accepts New Drug Application for Priority Review of Investigational HIV Treatment TMC125
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 2014 The employees of Pharmica ... Washington Crossing, Pennsylvania on Thursday, August 7th to spend ... been looking for different ways that Pharmica could get ... with Pharmica Consulting. “When we heard that we could ... we jumped at the opportunity.” , Pharmica spent their ...
(Date:8/21/2014)... 21, 2014 Sometimes you have to lose the ... new book “From Zero to a Hundred: Finding My Purpose through ... story of surviving a broken family, a childhood of gang violence ... who you were created to be,” Roy said. “I didn’t give ... I know my purpose today of helping others overcome their trials.” ...
(Date:8/21/2014)... Michael E. Steuer , local doctor in ... the Bluff City with recent philanthropy at local synagogue. “The ... United States,” says friend and Rabbi David Julian of Or ... as providing in-house for the needy and teaching Hebrew to ... the local synagogue. And to remain close with the development ...
(Date:8/21/2014)... Drake University’s Phi Gamma Delta (FIJI) and ... cancer research, according to Billy Cundiff, President of Colleen’s ... for the Cleveland Browns, says the money raised by ... Dream Foundation and will fund research to be conducted ... Division of Gynecologic Oncology at the University of Iowa’s ...
(Date:8/21/2014)... Recently, BambooIndustry.com, one of the most famous ... new range of hand scraped bamboo floorings ... an Autumn special offer for these elegant items. According ... a discounted price, up to 25% off; the promotion ... , Providing natural looks and available in different varieties, ...
Breaking Medicine News(10 mins):Health News:Pharmica Spends the Day Helping to Preserve Washington Crossing Historic Park 2Health News:Zero to a Hundred: True Story of Escaping Death to Meet Life 2Health News:Drake University’s Phi Gamma Delta (FIJI) and Colleen’s Dream Foundation Donate $10,000 to the University of Iowa’s Holden Cancer Center to Fight Ovarian Cancer 2Health News:Drake University’s Phi Gamma Delta (FIJI) and Colleen’s Dream Foundation Donate $10,000 to the University of Iowa’s Holden Cancer Center to Fight Ovarian Cancer 3Health News:Cheap Hand Scraped Bamboo Floorings Recently Unveiled by BambooIndustry.com 2
... Anderson Hospital administration and their ED process improvement ... the ED Patient Throughput Team at ... The ED Patient Throughput Team, responsible for reducing wait times ... three finalists to receive the award for their excellence in ...
... higher in moms-to-be who snore, study finds , THURSDAY, June ... more likely to develop gestational diabetes, new research has found. ... survey when they were between six and 20 weeks pregnant, ... that pregnant women who were frequent snorers -- defined as ...
... ... him uniquely qualified to lead NVCI , ... Las Vegas, NV (PRWEB) June 11, 2009 -- Stephen J. ... as Chairman of the Board for the Nevada Cancer Institute (NVCI) effective July 1, ...
... As a result of the economic climate, high-technology and ... in addition to extending cost controls for their current ... Aon Consulting,s Radford, a leading provider of compensation intelligence ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20041215/CGW049LOGO ) , ...
... had best results in study , THURSDAY, June 11 (HealthDay ... diabetes, may also help non-diabetic obese people lose weight when ... Researchers divided 152 obese men and women (with a body-mass ... 241 pounds) into two groups. About 25 percent of the ...
... Researchers at Nationwide Children,s Hospital and Johns Hopkins University ... highly expressed in normal tissues but lost in diseased ... (miRNA) are a class of small RNA molecules that ... in gene expression and in maintaining normal cell development ...
Cached Medicine News:Health News:Anderson ED Team Receives Pinnacle Award for Excellence in Customer Service 2Health News:Anderson ED Team Receives Pinnacle Award for Excellence in Customer Service 3Health News:Frequent Snoring in Pregnancy Could Signal Blood Sugar Trouble 2Health News:Nevada Cancer Institute Names Stephen J. Cloobeck Chairman of the Board 2Health News:Nevada Cancer Institute Names Stephen J. Cloobeck Chairman of the Board 3Health News:Bonus Payout Trends and Continuing Cost Controls Reflect Challenging Business Climate, Says Aon Consulting's Radford 2Health News:Bonus Payout Trends and Continuing Cost Controls Reflect Challenging Business Climate, Says Aon Consulting's Radford 3Health News:Bonus Payout Trends and Continuing Cost Controls Reflect Challenging Business Climate, Says Aon Consulting's Radford 4Health News:Diabetes Drug Byetta May Aid Weight Loss in Obese Patients 2Health News:Study shows promise for new cancer-stopping therapy 2
(Date:8/20/2014)... , Aug. 20, 2014 ApolloDx™ today announced ... platform during a special event at the company,s office ... on September 5, 2014. The event, which will start ... ApolloDx website, www.apollodx.com .    "We ... said Jared Bauer , Co-Founder and Managing Partner ...
(Date:8/20/2014)... DIEGO , Aug. 20, 2014 Trovagene, ... diagnostics, announced today that results from two clinical studies ... conference for the Company,s urine-based diagnostic test for the ... The IPV conference is scheduled to take place in ... to 25 th . Additionally, a new U.S. ...
(Date:8/20/2014)... Phase I Trial of Plasma ... KalVista Pharmaceuticals ("KalVista"), an ophthalmology company with a ... it has begun a Phase I, First in Human, ... the treatment of DME. The study,s Principal Investigator is ... Joslin Diabetes Center; Harvard Medical School Department of Ophthalmology, ...
Breaking Medicine Technology:Trovagene Provides Update on Its Urine-Based HPV Test 2Trovagene Provides Update on Its Urine-Based HPV Test 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 2KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 4
... conjunction with DURECT Corporation,s (Nasdaq: DRRX ) fourth ... listen to the conference call that will be broadcast live ... pm Eastern Time (1:30 pm Pacific Time). (Logo: ... the presentation will be available by accessing DURECT,s homepage at ...
... -- The SimplyGo Portable Oxygen Concentrator by Philips ... continuous flow and pulse does at a weight of only ... lightest weight continuous flow portable concentrator weighed in at a ... voltage meaning anywhere you go in the world you can ...
Cached Medicine Technology:SimplyGo Portable Oxygen Concentrator Now Available 2
Straight shafts and serrated handle with polished finish. Teeth: Fine 1 x 2 teeth. Most popular size or model....
Straight shafts with fine Pierse type tips. Flat smooth handle with dull finish....
Titanium. Straight shafts with 6 mm platform and Pierse tips. Flat serrated handle with dull finish....
0.12 mm, 1 x 2 teeth set at 45 degrees with 5 mm tying platform. Serrated handle with polished finish....
Medicine Products: