Navigation Links
Investigational anti-restenosis drug pimecrolimus disappoints
Date:3/31/2008

CHICAGO, Ill. (March 31, 2008) A new medication that researchers had hoped would reduce the risk of arterial renarrowing after stenting has turned in a disappointing performance in a multicenter clinical trial, but the multi-reservoir stent that was used to deliver the drug is still considered promising.

Pimecrolimus, an anti-inflammatory medication, was expected to reduce arterial inflammation and, therefore, the overgrowth of scar tissue, or neointimal hyperplasia, that causes in-stent restenosis. Instead, patients treated with pimecrolimus-eluting stents fared far worse than patients treated with stents that delivered a combination of pimecrolimus and paclitaxel, or paclitaxel alone, according to the Randomized, Multi-Center Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries (GENESIS). Paclitaxel is also an anti-restenosis medication, but it works by inhibiting cell division, rather than by reducing arterial inflammation.

The GENESIS study was terminated early by its sponsors. The data gathered to that point are being reported today in a Late-Breaking Clinical Trials session at the SCAI Annual Scientific Sessions in Partnership with ACC i2 Summit (SCAI-ACCi2) in Chicago. SCAI-ACCi2 is a scientific meeting for practicing cardiovascular interventionalists sponsored by the Society for Cardiovascular Angiography and Interventions (SCAI) in partnership with the American College of Cardiology (ACC).

Despite pre-clinical data suggesting marked efficacy of pimecrolimus in suppressing neointimal hyperplasia, the extent of tissue growth and resulting rates of target vessel revascularization at six months were high in patients treated with this drug, said Stefan Verheye, MD, PhD, co-director of the catheterization laboratories at Antwerp Cardiovascular Center, ZNA Middelheim Hospital, Antwerp, Belgium.

The GENESIS study was als
'/>"/>

Contact: Kathy Boyd David
pr@scai.org
717-422-1181
Weber Shandwick Worldwide
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Investigational drug tested for preventing muscle fiber death in muscular dystrophy
2. Enrollment completed in 2 pivotal phase III studies of the investigational cancer drug vandetanib
3. New Drug Application Submitted to FDA for Investigational Analgesic Tapentadol Immediate Release Tablets
4. UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
5. SGX Pharmaceuticals Submits Investigational New Drug Application for SGX523, a Highly Potent, Selective, Orally Bioavailable cMET Inhibitor
6. MetaCure(TM) Launches Investigational Study of Gastric Stimulator for Patients With Type 2 Diabetes Who are Overweight
7. Abbotts Investigational SIMCOR(R) Offers Comparable LDL Lowering to Simvastatin and Significantly Raises HDL and Lowers Triglycerides in Phase III Study
8. Dynavax and Merck & Co., Inc. Announce Partnership to Develop HEPLISAV(TM), an Investigational Hepatitis B Vaccine Currently in Phase 3
9. Ono and Medarex Announce Allowance of Investigational New Drug Application for Fully Human Anti-PD1 Antibody
10. Supratek Pharma Inc. announced today that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for SP1049C for the treatment of metastatic adenocarcinoma of the upper gastrointestinal tract
11. Accentia announces investigational new drug application for Revimmune for refractory MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... FL (PRWEB) December 17, 2014 No ... not been able to eradicate the head louse parasite—a ... hassle for parents. Each year between six and twelve ... Troopers, the Miami-based lice removal treatment company comes to ... non-toxic and environmentally friendly. With its track record of ...
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... Kathleen Doheny HealthDay ... Chronic sleep loss is rampant in America, and work commitment ... is the No. 1 sleep killer," said Dr. Mathias Basner, ... the University of Pennsylvania Perelman School of Medicine. A ... older, found that work is the main activity exchanged for ...
(Date:12/15/2014)... South Florida’s leading urgent care provider, ... a daze of hassle, hustle, and bustle that can cause ... to burns when making special meals and heartburn after eating ... at any time. To prevent this season of joy from ... list of helpful and healthful holiday tips to keep the ...
(Date:12/15/2014)... pilots process visual information more efficiently than less experienced ... landings, a new study shows. Landing is one ... and 36 percent of all airplane crashes and 25 ... landing. Researchers monitored the brain activity of eight ... were at the controls of a flight simulator. As ...
Breaking Medicine News(10 mins):Health News:Lice Troopers Announces New Lice Treatment Clinic in Coral Gables to Service Key Biscayne, Coconut Grove, Kendall, Brickell & South Miami 2Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2
... on relatives and friends of patients towards phoning them at their ... has called for reductions in the phone charges as well as ... case it was found that charges as high as 1.50 pounds ... the provider of the hospital bedside phone service says its top ...
... government has filed police complaints against 21 doctors alleged ... foeticide.// ,The director of family welfare, acting on ... against the doctors with the Ashok Nagar police station ... filed FIRs (first information reports) against 21 doctors working ...
... A study published in the British Journal of Clinical Pharmacology ... be prevented by providing morning-after pill at local pharmacies //as ... from South West Kent Primary Care Trust and the University ... 20 who got the medication from family planning clinics and ...
... women to give birth to their babies at home if they ... dispel myths that a hospital was the best place to bring ... has already taken the first step by asking for a commission ... are committed to offering all women the choice of how and ...
... a public confession, during his speech at the Center for ... had spent precious// five years in the throes of drug ... he is also gay, the minister spoke of his suffering ... due to courage and conviction. , ,"It made me ...
... conducted by the researchers of Obstetricians and Gynecologists at the ... women// can be tiresome and complicated. They say that this ... case of obese pregnant women it takes a longer time ... presented at the annual meeting of the American College of ...
Cached Medicine News:Health News:Patients Indignant at Exorbitant Phone Bills from Hospital 2Health News:Morning-After Pill At The Local Pharmacy Could Prevent Unwanted Pregnancies 2Health News:Morning-After Pill At The Local Pharmacy Could Prevent Unwanted Pregnancies 3
(Date:12/13/2014)... DUBLIN , Dec. 11, 2014 Research ... announced the addition of the "Drug Injection ... http://photos.prnewswire.com/prnh/20130307/600769 ... treatment of an expanding list of health conditions, ... options that simplify the administration process and increase ...
(Date:12/13/2014)... , Dec. 12, 2014 HudsonAlpha ... the HiSeq X Ten sequencing system manufactured by ... HudsonAlpha to produce and analyze genomic data faster ... from the Institute,s commitment to research programs for ... HiSeq X Ten provides unprecedented capacity, speed and ...
(Date:12/13/2014)... and INDIANAPOLIS , Dec. 12, 2014 ... Chip Ganassi Racing Teams (CGRT), today announced a multi-year extension ... primary sponsor of the No. 83 Novo Nordisk Chip Ganassi ... Verizon IndyCar Series. Kimball, 29, from ... licensed driver with diabetes in the history of INDYCAR to ...
Breaking Medicine Technology:Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... PITTSBURGH , Feb. 4 Mylan Inc. (Nasdaq: ... in connection with the filing of an Abbreviated New Drug Application ... Besylate and Atorvastatin Calcium Tablets 2.5/10 mg, 2.5/20 mg, 2.5/40 mg, ... mg, 10/40 and 10/80 mg. This product is the generic version ...
... ... Wound Management Technologies, Inc. (OTC Bulletin Board: WNDM) announced today ... with GSI Health.  GSI Health is led by Leroy E. ... the Consulting Agreement , GSI Health will focus primarily on the ...
Cached Medicine Technology:Mylan Confirms First-to-File Patent Challenge Relating to Caduet(R) 2Secure eHealth, LLC Engages as a Consultant GSI Health Whose Principal and CEO is the Former Senior Advisor to National Coordinator for Health Information Technology 2Secure eHealth, LLC Engages as a Consultant GSI Health Whose Principal and CEO is the Former Senior Advisor to National Coordinator for Health Information Technology 3Secure eHealth, LLC Engages as a Consultant GSI Health Whose Principal and CEO is the Former Senior Advisor to National Coordinator for Health Information Technology 4Secure eHealth, LLC Engages as a Consultant GSI Health Whose Principal and CEO is the Former Senior Advisor to National Coordinator for Health Information Technology 5Secure eHealth, LLC Engages as a Consultant GSI Health Whose Principal and CEO is the Former Senior Advisor to National Coordinator for Health Information Technology 6
100L...
... pipette is ideal for repeated ... Fixed volume FInnpipettes offer the ... other Finnpipette Digital pipettes: ... (1-40ul), Soft-touch tip ejection, Safety ...
This fixed-volume digital micropipet is used to accurately measure and transfer 20 microliters of solution....
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Medicine Products: