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Investigational Drug May Help Avert Blood Clots
Date:3/13/2009

and that it might offer a better way to control bleeding and blot clot formation during PCI. Thrombin is a protein in the blood that activates platelets, particles that clump together to form the scaffolding of a clot. Thrombin also helps produce fibrin, a protein that plays an important role in repairing damaged tissue.

"One of the intriguing things about this new investigational compound is that it blocks the thrombin receptor that activates platelet formation yet preserves the beneficial activity of fibrin formation." Dr. Richard Becker, a cardiologist and the study's lead author, said in a Duke news release. "And the data to date indicate the compound does this even when patients are taking aspirin and clopidogrel."

An international, phase 3 study of the new drug is under way, the researchers said.

More information

The American Heart Association has more about PCI.



-- Robert Preidt



SOURCE: Duke Medicine, news release, March 12, 2009


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