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Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
Date:9/2/2007

ebo-controlled, short-term schizophrenia and bipolar mania trials was somnolence. Other common events were dizziness, weight gain, personality disorder (COSTART term for nonaggressive objectionable behavior), constipation, akathisia, postural hypotension, dry mouth, asthenia, dyspepsia, increased appetite and tremor.

Full prescribing information, including a boxed warning, is available at http://www.zyprexa.com.

About Schizophrenia

Schizophrenia is a severe and debilitating psychosis often characterized by acute episodes of delusions (false beliefs that cannot be corrected by reason), hallucinations (usually in the form of non-existent voices) and long- term impairments such as diminished emotion, lack of interest and depressive signs and symptoms, such as hopelessness and suicidal thoughts.(1) It is usually associated with a disruption in social and family relationships. Schizophrenia is the most common severe mental illness. Twenty four million people suffer from schizophrenia worldwide. (2,3)

About Lilly

Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers - through medicines and information - for some of the world's most urgent medical needs. Additional information about Lilly is available at http://www.lilly.com.

(Logo: http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO )

C-LLY

Zyprexa(R) (olanzapine, Lilly)

(1) Weiden P, Scheifler P, Diamond R, et al. Breakthroughs in

Antipsychotic Medications. New York: W.W. Norton & Company, 1999.


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