Navigation Links
Investigation finds that cigarette smoking does not affect everyone in same way
Date:6/4/2009

This release is available in French.

Montreal, June 4th, 2009 Cigarette smoking induced COPD, or chronic obstructive pulmonary disease, is a disease that results in severe breathing difficulty. According to World Health Organization (WHO) it is the fourth leading killer worldwide. However the mechanisms responsible for some smokers developing COPD and others evading the disease have not been well understood.

Dr.Manuel Cosio from the McGill University Health Centre, in collaboration with Italian and Spanish scientists, reports in the New England Journal of Medicine that an autoimmune mechanism, compounded by genetic predisposition in COPD, would explain the progression of the disease in some smokers and the evasion in others. COPD has a family connection and next of kin of patients with COPD have a much higher chance of developing the disease, a characteristic of autoimmune diseases.

Although smoking is the primary risk factor for COPD in the western world, open fire pollutant cooking and heating fuels in the home is an important risk factor for the development of COPD in women in developing nations. "Smoke can play an important role in autoimmune diseases such as COPD, and other diseases like rheumatoid arthritis, because it accentuates genetic predispositions to the disease," warns Dr. Cosio.

Yet contrary to previous scientific beliefs, COPD does not progress in the same way in all smokers. The authors describe three steps in the potential progression to COPD in smokers: "COPD does not go from stage one, two and three in all people," Dr. Cosio says. "Depending on their personal balance between immune response and immune control some people would stop at stage one, others at stage two, and some will progress to stage three, full autoimmunity and lung destruction."

"Hopefully investigators will now see the disease in a totally different way," Dr Cosio stresses. "Our hope is that our research will open the door for a different investigation on COPD, where scientists learn more about the immunological processes and how these processes could be controlled and modulated to eventually provide the right treatment."


'/>"/>

Contact: Isabelle Kling
isabelle.Kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Related medicine news :

1. Abbott and AstraZeneca Submit New Drug Application to the FDA for CERTRIAD(TM), an Investigational Treatment for Mixed Dyslipidemia
2. XTENT, Inc. Receives Conditional Approval for Investigational Device Exemption of Custom NX(R) Drug Eluting Stent System from United States Food and Drug Administration
3. Dissident Stockholder Ted Karkus Found to Have Undisclosed Financial Arrangements With Dr. Richard A. Rosenbloom, COO Of Quigley Pharma, From 2008 to Date of Proxy: Rosenbloom Suspended Without Pay Pending Further Investigation
4. Schering-Plough Starts Patient Enrollment in Phase 3 Trial for Acadesine, an Investigational Agent Being Studied for Prevention of Complications From Cardiac Surgery
5. PHR Calls for Investigation of American Psychological Association's Ties to Pentagon
6. DaVita Announces Completion of Government Investigation
7. Drug therapy reduces neuroblastoma tumor growth in pre-clinical investigation
8. Ethicon Endo-Surgery Novel Investigational Notes and SSL Devices Featured in 15 Presentations at Sages
9. Forest Laboratories, Inc. Reports Fiscal Year 2009 Fourth Quarter Reported EPS of $0.31 Including $0.45 Per Share Charge Related to the Ongoing United States Attorneys Office Investigation
10. Hazardous Health Plans: Consumer Reports Investigation Finds Serious Gaps in Individual Health Insurance Policies
11. As a Result of the FDA Investigation Into TNF-Alpha Inhibitors, 30 Percent of Surveyed Rheumatologists Have Altered Their Prescription Patterns for Juvenile Idiopathic Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: