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Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma
Date:2/27/2008

in the majority of mice studied. One particular line of transgenic mice exhibited the inversion in 15 of 15 tumors they examined. Genetic recombination is a frequent component of T-cell malignancies, but it is startling to see this same pattern come up repeatedly, Testa says.

In subsequent cell studies, Testa and his colleagues determined that the combined activation of both Dlx5 and Akt2 could result in increased cell growth and proliferation. While their findings are the first to assert that Dlx5 can be an oncogene, the gene has previously been implicated in a number of human endometrial and lung cancers. Moreover, the DLX5 protein was found in abundant amounts within three out of seven human lymphomas that the Fox Chase researchers examined.

According to Testa, molecules that could bind and inhibit DLX5 could provide a more useful drug for therapeutic development than could molecules that inactivate AKT2.

The AKT family of proteins is crucial to survival in both cancerous and non-cancerous cells, so AKT2 is a potentially risky target for drug development since blocking AKT2 can also kill healthy cells, Testa says. DLX5, however, is not generally active in healthy adult cells, so it represents a much more druggable target for inhibition.


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Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

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