Navigation Links
Inverse benefits due to drug marketing undermine patient safety and public health
Date:1/13/2011

GALVESTON, TX Drugs that pharmaceutical companies market most aggressively to physicians and patients tend to offer less benefit and more harm to most patients a phenomenon described as the "inverse benefit law" in a paper from the University of Texas Medical Branch at Galveston.

Published online Thursday, Jan. 13 in the American Journal of Public Health, the article explores recent withdrawals of blockbuster drugs due to safety concerns and finds a clear pattern of physician-focused marketing tactics that ultimately exposed patients to a worsening benefit-to-harm ratio. Potential patient safety and public health implications include unnecessary exposure to adverse side effects, high medical costs and competition for scarce resources.

"This is not a random occurrence, but rather a repeating, planned scenario in which drugs, discovered with good science for a specific set of patients, are marketed to a larger population as necessary, beneficial and safer than other alternatives," said co-author Dr. Howard Brody, a professor and director of the Institute for the Medical Humanities at UTMB Health. "Marketers are just doing their jobs. However, the reality is that for most new drugs, safety and efficacy are scientifically proven for only a small subset of patients. It's time for physicians to take a stand and not prescribe them so readily."

The inverse benefit law, coined by the authors and inspired by Hart's inverse care law (1), is manifested in marketing techniques commonly deployed to extend a drug's use beyond the proper evidence base. Brody and co-author Donald W. Light, a professor at the University of Medicine and Dentistry of New Jersey, identify these strategies and illustrate the "law" with recent examples:

  • Guidelines that reduce diagnostic thresholds and rely on surrogate endpoints as seen in the steady lowering of blood glucose levels at which diabetes should be diagnosed to support glitazone
    '/>"/>

Contact: Olivia Goodman
olivia.goodman@gabbe.com
212-220-4444
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Strength training for seniors provides cognitive function, economic benefits: VCH-UBC study
2. Implanted Heart Devices Have Real-World Benefits: Study
3. Economic benefits of the global polio eradication initiative estimated at $40-50 billion
4. Resistance Exercise May Offer Different Cardio Benefits
5. Bilingual benefits reach beyond communication
6. Study shows volunteering benefits those with functional limitations
7. Many women missing out on the benefits of cardiac rehab
8. ER patients prefer ordering physicians discuss risks/benefits of CT with them before ordering exam
9. Winter Runners Reap Physical, Mental Benefits: Expert
10. Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors
11. Benefits of increased health care transparency hinge on reliable and valid information, says ACP
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... BambooFlooringChina.com sells many bamboo products and the ... the company announces big discounts on its bamboo ... , BambooFlooringChina.com is the world’s leader in bamboo flooring. ... until Jan. 20, 2015. , The bamboo mats are ... natural thread. All the bamboo strips for the mats ...
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... with complex chronic illnesses can receive effective, less expensive care ... easy access to a team of dedicated health care professionals, ... become seriously ill and need either hospitalization or a trip ... enhanced medical home clinic at the University of Texas in ...
(Date:12/25/2014)... is common during the holidays, but there are strategies that ... "Don,t arrive at a party hungry. It may seem logical ... a party, but deprivation leads to hunger, and hunger leads ... in Mount Kisco, N.Y., said in a hospital news release. ... even to have a snack before attending a party when ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... could be closing in on a "fountain of youth" drug ... health of older adults, a new study suggests. Seniors ... a drug that targets a genetic signaling pathway linked to ... report. The experimental medication, a version of ...
Breaking Medicine News(10 mins):Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3
... Oct. 3 EpiCept Corporation,(Nasdaq and OMX Nordic ... CEO, will be presenting at the 2007 BIO ... time at the Palace Hotel in San,Francisco, California. ... (LOGO: http://www.newscom.com/cgi-bin/prnh/20020513/NYM112LOGO ) The presentation ...
... Veto Will Deprive Six Million American Children of Healthcare ... of,Child and Adolescent Psychiatry strongly urges Congress to override,President ... 976) act., The House passed the S-CHIP bill ... enough to override the President,s veto. The Senate passed ...
... G. Komen for the Cure; $6.3 Million Raised to ... ... professional athletes and other celebrities are teaming up,with American Airlines this weekend to ... Golf and Tennis Weekend,Oct. 4-7 at the Four Seasons Resort Aviara and the ...
... JOSE, Calif., Oct. 3 VNUS(R) Medical,Technologies, Inc. (Nasdaq: ... the minimally invasive treatment of venous reflux disease, today,announced ... Small-Cap Growth,Stock Conference at 10:00 a.m. ET on October ... York, New York. An archive of the VNUS ...
... Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) announced today that ... 10, 2007, at 11:45 a.m. PDT (2:45,p.m. EDT). The ... San,Francisco. Steve Worland, Ph.D., President and Chief Executive ... Anadys and an update on,its two development-stage product candidates, ...
... W. Va., Oct. 3 A new Web site ... organizations. "This was a five-year development effort in ... York and Ohio to perfect the,application of Web site ... The site, http://www.NorthwoodHealth.com, offers more than ...
Cached Medicine News:Health News:EpiCept Corporation to Present at the 2007 BIO InvestorForum 2Health News:EpiCept Corporation to Present at the 2007 BIO InvestorForum 3Health News:American Academy of Child and Adolescent Psychiatry Reacts to S-CHIP Veto 2Health News:American Airlines 13th Annual Celebrity Golf and Tennis Weekend Will Raise Funds to Fight Breast Cancer 2Health News:American Airlines 13th Annual Celebrity Golf and Tennis Weekend Will Raise Funds to Fight Breast Cancer 3Health News:Anadys Pharmaceuticals to Present at BIO InvestorForum 2007 2
(Date:12/24/2014)... and FARMINGTON, Conn. , ... (NYSE MKT: PTN), a biopharmaceutical company developing targeted, ... with significant unmet medical need and commercial potential, ... private placement of 2,050,000 shares of its common ... shares of its common stock.  Funds under the ...
(Date:12/24/2014)... ResMed (NYSE: RMD ) today announced its victory ... manufacturer BMC Medical Co., Ltd. The International ... infringe ResMed,s patents, and entered an order prohibiting BMC from ... United States : , iVolve nasal mask ... pillows mask , iVolve full face mask ...
(Date:12/24/2014)... ALEXANDRIA, Va. , Dec. 23, 2014 /PRNewswire-USNewswire/ ... stringent diastolic blood pressure target for people with ... either moderate or high doses of statins, in ... risk management enacted by the American College of ... recommendations are reflected in the most recent changes ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4
... 2011 HealthWarehouse.com, Inc. (OTC Bulletin Board: ... Huntington Insurance , a wholly-owned subsidiary of Huntington ... in employee benefits products, announced today a partnership that ... generic prescription medication.   HealthWarehouse.com will be ...
... Calif., Feb. 13, 2011 Samplify Systems, Inc., ... for the ultrasound equipment market, announced today that ... Senior Scientist, where he will apply his expertise ... generation of ultrasound beamforming technology and products. ...
Cached Medicine Technology:HealthWarehouse.com and Huntington Insurance Partner to Help Self-Insured Employers in the Midwest Save on Prescription Medications 2Ultrasound Industry Expert, Chris Daft, Joins Samplify Systems 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: