Navigation Links
Inventive combination of research approaches identifies new target for treating leukemia
Date:10/5/2009

New research integrates sophisticated interdisciplinary approaches to solve a molecular mystery that may lead to alternative therapeutic strategies for acute myeloid leukemia (AML). The study, published by Cell Press in the October issue of the journal Cancer Cell, identifies a previously unrecognized AML target that responds well to pharmacological inhibition and may be an excellent candidate for use in future clinical trials.

AML is a type of blood cancer that disrupts normal blood cell production. "Long term survival for patients with AML remains poor despite dose-intensive chemotherapy regimens," explains senior study author, Dr. Kimberly Stegmaier from Dana-Farber Cancer Institute, Broad Institute of Harvard and MIT, and Children's Hospital Boston. "For older adults, long-term survival is dismal, and many older patients are unable to tolerate standard cytotoxic therapy." Unfortunately, identification of new treatment strategies has proven difficult as many potential targets are proteins that do not respond well to standard pharmacological methods.

Another challenge has been to unravel the molecular mechanisms associated with compounds that inhibit or reverse AML progression. Target identification is necessary for optimization of drug treatment. Dr. Stegmaier and colleagues had previously demonstrated that epidermal growth factor receptor (EGFR) inhibitors exhibited anti-AML activity. However, this finding was somewhat puzzling as EGFR is not expressed in AML. The researchers made use of sophisticated cross-disciplinary approaches to study gene expression (genomics) and protein structure and function (proteomics) to elucidate the molecular basis for the effect of EGFR inhibitors in AML.

Spleen tyrosine kinase (Syk) was identified as a target in AML. Syk is expressed in blood cells and is critical for proper blood cell differentiation. Recent research has implicated Syk in blood cancers, specifically lymphomas and leukemia
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Modern Health Care Economics is Driving Inventiveness in Delivery of Cancer Surgery and Management of Risk
2. Combination of PET/CT tests can expedite diagnosis of lung cancer in a fast-track setting
3. Results Reported for Exploratory Phase 2 Study of Nexavar in Combination With Chemotherapeutic Agent Paclitaxel for Treatment of Advanced Breast Cancer
4. Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression-Free Survival in Patients With Advanced Breast Cancer in Phase 2 Study
5. More Sleep & Less Sex - A Losing Combination
6. Novartis Receives FDA Approval for Valturna(R), a Single-Pill Combination of valsartan and aliskiren, to Treat High Blood Pressure
7. Diabetes Drug Kills Cancer Stem Cells in Combination Treatment in Mice
8. Mega-Catch™ 3000 Combination Lure Attracts Asian Tiger Mosquitoes (Aedes Albopictus)
9. Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination
10. Large Majority of Drivers 55 and Older Unaware of Potentially Dangerous Combination of Medications and Driving, Says New AAA Foundation Study
11. BBV Vietnam S.E.A. Acquisition Corp. Announces Signing of Letter of Intent for Business Combination with Migami, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... Health notes that while an overwhelming number of Hispanics believe people can ... The overwhelming 70 percent of participants queried said making diet changes was important. ...
(Date:8/3/2015)... ... 2015 , ... Dental practice in Los Angeles , Sunset Plaza Dental, ... that general health emergencies, such as broken arms or a heart attack, should be ... turn to during a dental emergency. This is important, because dental trauma is extremely ...
(Date:8/3/2015)... ... , ... The art of preparing and cooking food comes naturally to some. ... age, Nasreen Zereshki was extremely eager to cook Persian cuisine. Now that she is ... Persian Kitchen with the world. , Since Americans tend to be undereducated about Persian ...
(Date:8/3/2015)... ... August 03, 2015 , ... Sensato and ... “Designing Secure Healthcare Systems” This three-day, highly interactive and immersive workshop, has ... with access to the tactics, techniques and practices required to design and develop ...
(Date:8/3/2015)... Los Angeles, CA (PRWEB) , ... August 03, 2015 , ... ... trend has emerged among U.S. emergency rooms in recent years, according to the American ... 2012, the number of dental emergency visits went from 1.1 million in a single ...
Breaking Medicine News(10 mins):Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 4Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 2Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 3Health News:Persian Cuisine: Colorful and Extremely Healthy 2Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 2Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 3Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 4Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 2Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 3
... without hepatocellular carcinoma (HCC) derive a greater survival benefit ... for a deceased donor liver transplant (DDLT). The study ... journal published by Wiley-Blackwell on behalf of the American ... survival benefit from LDLT remains significant across the range ...
... , TUESDAY, Sept. 27 (HealthDay News) -- ... lethal prostate cancers have been identified by scientists who ... of cancers. The team also identified several instances ... that can give the cancers resistance to therapies commonly ...
... negative effects that premature birth can have on the lungs ... as those born extremely prematurely but may be reversed in ... research will be presented at the European Respiratory Society Annual ... lasts 40 weeks, which allows enough time for the infant ...
... For all long-term care residents, pressure reduction foam mattresses ... mattresses, with average savings of $115 per resident, the ... cost-effective 94% of the time compared to soap and ... The clinical benefits of foam cleansers for bedsores, or ...
... , MONDAY, Sept. 26 (HealthDay News) -- Older women ... within a year because of the fracture, not an underlying health ... that it is the hip fracture, and not just poor health, ... author Dr. Teresa Hillier, a senior investigator at the Kaiser Permanente ...
... Doctors and other medical professionals occasionally joke about their ... but some joking between medical professionals is not only ... in the Hastings Center Report . The ... and comedy: she is an assistant professor in the ...
Cached Medicine News:Health News:Living donor liver transplantation improves survival over deceased donor transplants 2Health News:Lung function of moderately premature babies is reduced at 8-9 years but may improve with age 2Health News:Prevention of bedsores in long-term care homes cost-effective, study shows 2Health News:Hip Fracture May Raise a Woman's Risk of Earlier Death 2Health News:Is gallows humor in medicine wrong? 2
(Date:8/3/2015)... , Aug. 3, 2015 Immune Pharmaceuticals, Inc. ... Dr. Daniel Teper , will present live at ... 6, 2015 TIME:   11:30AM EDT LINK:    http://tinyurl.com/aug6-pre-imnp ... interactive online event where investors are invited to ask ... presentation hall as well as the association,s "virtual trade ...
(Date:8/3/2015)... SAN DIEGO , Aug. 3, 2015  Sorrento ... that it has entered into an exclusive licensing agreement ... or biobetter antibodies from Mabtech Limited, a holding company ... China . Under the ... these 4 monoclonal antibodies (mAbs) for the North American, ...
(Date:7/31/2015)... , July 31, 2015  In today,s ever-changing marketplace, ... are increasingly mobile, increasingly connected, and increasingly impatient with ... of customer interaction channels and tools is driving call ... media. According to research by benchmarking ... counter (OTC) segment in a call center study realize ...
Breaking Medicine Technology:Immune Pharmaceuticals to Webcast Live at VirtualInvestorConferences.com August 6 2Sorrento In-Licenses Four Late-Stage Clinical Biobetter and Biosimilar Antibodies 2Sorrento In-Licenses Four Late-Stage Clinical Biobetter and Biosimilar Antibodies 3Sorrento In-Licenses Four Late-Stage Clinical Biobetter and Biosimilar Antibodies 4Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2
... , ABBOTT PARK, Ill., July 28 ... Food and Drug Administration (FDA) approval for two new ... SIMCOR dosage strengths combine 40 mg of simvastatin – ... either 500 mg or 1,000 mg of niacin extended-release. ...
... In FDLI,s latest monograph, Selling Pharmaceuticals and Biologics to ... , Joy Sturm , Allison Pugsley ... Hogan Lovells US LLP detail how pharmaceutical and ... price calculation requirements. The 73-page monograph (Volume 1, #5) succinctly ...
Cached Medicine Technology:Abbott's SIMCOR ® ( niacin extended-release / simvastatin ) Receives FDA Approval for New Dosage Strengths 2Abbott's SIMCOR ® ( niacin extended-release / simvastatin ) Receives FDA Approval for New Dosage Strengths 3New FDLI Monograph Provides Expert Guidance on Selling Pharmaceuticals, Biologics to Federal Government 2
A single tube that performs two rapid tests for E. coli from culture. ColiScreen™ combines both the indole test with the glucuronidase test to increase the specificity....
Legionella provides rapid, accurate results that aid in the presumptive diagnosis of Legionella infection (Legionnaires' Disease)....
... Captia™ Legionella pneumophila IgG/IgM Enzyme-Linked ... for the qualitative detection of ... to Legionella pneumophila (Legionella) serogroups ... with clinical suspicion of Legionella ...
The GoodKnight® 425 Bi-Level® device is suitable for travel and includes features such as automatic altitude compensation, optional cigarette lighter adapter and portable battery pack...
Medicine Products: