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Invasive melanoma may be more likely in children than adults
Date:10/5/2011

r tumor thickness compared with older children and with young adults, the researchers found. Patients with bleeding tumors or those with open sores were more likely to have metastases regardless of age, the study found.

Survival rates did not differ significantly by age among those with metastatic melanoma.

Researchers say the discrepancy in metastatic disease likely stems from underlying biological differences between pediatric and adult melanomas.

"Our finding is a powerful reminder that there's much about pediatric melanoma that we don't understand and that, just as is the case with other diseases, children are not small adults, but differ markedly in their response to disease," says senior investigator John Strouse, M.D., Ph.D., a pediatric hematologist and oncologist at the Johns Hopkins Children's Center.

The National Cancer Institute predicts more than 70,000 new diagnoses of melanoma and nearly 8,800 deaths in the United States in 2011 alone. Because melanoma remains relatively rare in children -- less than 4 percent of cases occur in pediatric patients -- both diagnosis and treatment can be dangerously delayed in this group, experts say.

Studies, however, have shown growing incidence of melanoma and non-melanoma skin cancer in children and young adults, experts say, and unprotected sun exposure, indoor tanning and repeated sun burns, especially during childhood, are some of the main drivers behind this trend.

"I advise parents to use sun screen religiously on infants and children during outdoor activities year round," says Bernard Cohen, M.D., director of pediatric dermatology at Johns Hopkins Children's Center. Cohen was not part of the current study.

Teens are another high-risk group, Cohen says, and pediatricians and parents should discuss with them the dangers of indoor tanning.


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Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medical Institutions
Source:Eurekalert

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