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Invasion without a stir
Date:12/17/2009

far as signature of successful host cell invasion by this pathogen, the usefulness of such methods has to be reconsidered.

Finally, the researchers discovered a new piece in the puzzle of Salmonella entry, called WASH. This novel factor promotes bacterial invasion by contributing to the formation of host cell cytoskeletal filaments important for entry. "Our results have significant impact on the molecular and mechanistic understanding of the infection strategy used by this pathogen," says Rottner, "and on the development of novel strategies to screen for potential inhibitors of the entry process in the future."


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Contact: Dr. Bastian Dornbach
bastian.dornbach@helmholtz-hzi.de
49-053-161-818-1407
Helmholtz Association of German Research Centres
Source:Eurekalert

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