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Invasion without a stir
Date:12/17/2009

"Based on our data, the molecular mechanism of infection employed by Salmonella has to be revised," says Klemens Rottner, head of the HZI research group "Cytoskeleton Dynamics". The group's results have now been published in the current issue of the scientific journal "Cellular Microbiology".

Salmonella are highly adaptive bacteria. They can live in the presence and absence of oxygen and thus propagate in the gut. The ingestion by humans occurs mainly via contaminated egg dishes such as mayonnaise or raw milk products as well as meat or sausages. Infections with Salmonella lead to severe diarrhea and fever, particularly in patients harbouring a compromised immune system.

Although Salmonella are long-known pathogens, the precise mechanisms of infection are incompletely understood. The bacteria inject a protein cocktail using a "molecular syringe" into host cells, leading to dramatic rearrangements of cytoskeletal filaments below the cell membrane. As a result, membrane waves are formed, which enclose the bacteria, and apparently facilitate their invasion. Those characteristic membrane waves are called "ruffles", the process is known as "ruffling". Until now, researchers regarded the formation of these ruffles as absolutely essential for bacterial entry.

In a collaborative effort, HZI research groups "Cytoskeleton dynamics" and "Signalling and Motility" now succeeded in shedding new light on the infection strategy of Salmonella. "We wanted to improve our mechanistic understanding of how Salmonella invade their host cells," says Jan Hnisch, who performed most experiments in the course of his PhD-thesis. Cells that were engineered to lack those membrane ruffles normally induced during Salmonella infection still engulfed the bacteria. "We showed for the first time that membrane ruffles are not essential for the bacteria to penetrate the host cell membrane." Since ruffling was used so
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Contact: Dr. Bastian Dornbach
bastian.dornbach@helmholtz-hzi.de
49-053-161-818-1407
Helmholtz Association of German Research Centres
Source:Eurekalert

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